domperidone has been researched along with Brugada Syndrome in 3 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Brugada Syndrome: An autosomal dominant defect of cardiac conduction that is characterized by an abnormal ST-segment in leads V1-V3 on the ELECTROCARDIOGRAM resembling a right BUNDLE-BRANCH BLOCK; high risk of VENTRICULAR TACHYCARDIA; or VENTRICULAR FIBRILLATION; SYNCOPAL EPISODE; and possible sudden death. This syndrome is linked to mutations of gene encoding the cardiac SODIUM CHANNEL alpha subunit.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The first author performed EMBASE, PubMed and Scopus searches to identify human studies assessing the association between current domperidone exposure and cardiac arrhythmia or sudden death." | 8.93 | Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis. ( Holcombe, A; Leelakanok, N; Schweizer, ML, 2016) |
| "The first author performed EMBASE, PubMed and Scopus searches to identify human studies assessing the association between current domperidone exposure and cardiac arrhythmia or sudden death." | 4.93 | Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis. ( Holcombe, A; Leelakanok, N; Schweizer, ML, 2016) |
| "A search of two bibliographic databases, the European Medicines Agency (EMA) website, Micromedex, Lexicomp and reference texts was undertaken for domperidone related reports of QT prolongation, cardiac arrhythmias and/or SCD." | 4.91 | Domperidone safety: a mini-review of the science of QT prolongation and clinical implications of recent global regulatory recommendations. ( Buffery, PJ; Strother, RM, 2015) |
| "Observational retrospective studies have linked domperidone and prolonged QT interval, ventricular arrhythmias and risk of sudden death." | 3.85 | [Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database]. ( Auffret, M; Béné, J; Gautier, S; Rochoy, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Buffery, PJ | 1 |
| Strother, RM | 1 |
| Leelakanok, N | 1 |
| Holcombe, A | 1 |
| Schweizer, ML | 1 |
| Rochoy, M | 1 |
| Auffret, M | 1 |
| Béné, J | 1 |
| Gautier, S | 1 |
2 reviews available for domperidone and Brugada Syndrome
| Article | Year |
|---|---|
Domperidone safety: a mini-review of the science of QT prolongation and clinical implications of recent global regulatory recommendations.
Topics: Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Death, Sudde | 2015 |
Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic Review and Meta-analysis.
Topics: Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; Case-Control | 2016 |
1 other study available for domperidone and Brugada Syndrome
| Article | Year |
|---|---|
[Antiemetics and cardiac effects potentially linked to prolongation of the QT interval: Case/non-case analysis in the national pharmacovigilance database].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiemetics; Arrhythmias, Cardiac; Brugada Syndrome; Car | 2017 |