domperidone has been researched along with Autoimmune Diabetes in 9 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To assess the effect of an 8-week course of domperidone or cisapride on gastric electrical activity, gastric emptying time and dyspeptic symptoms in children with insulin-dependent diabetes mellitus and gastroparesis." | 9.10 | Domperidone is more effective than cisapride in children with diabetic gastroparesis. ( Borrelli, O; Corrado, G; Cucchiara, S; Di Nardo, G; Dito, L; Franzese, A; Grandinetti, AL; Rea, P, 2002) |
| "A double-blind, multicenter, randomized trial was conducted to compare the side effects and efficacy of domperidone and metoclopramide in symptomatic diabetic gastroparesis." | 9.09 | A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis. ( Abell, T; Barnett, J; Koch, K; Patterson, D; Rothstein, R, 1999) |
| " A diagnosis of neuroleptic malignant syndrome was made, and the patient was given dantrolene with prompt and complete resolution of all signs and symptoms." | 7.68 | Neuroleptic malignant syndrome induced by domperidone. ( Chan, W; Sachar, DB; Spirt, MJ; Thieberg, M, 1992) |
| "The purpose is to evaluate the effectiveness of itopride (IP) and domperidone (DP) in the treatment of patients with gastroesophageal reflux disease (GERD), in combination with diabetes mellitus (DM) type 1 and 2." | 5.17 | [Comparative data of prokinetics in treatment of gastroesophageal reflux disease in patients with diabetes]. ( Fedorchenko, IuL, 2013) |
| "To assess the effect of an 8-week course of domperidone or cisapride on gastric electrical activity, gastric emptying time and dyspeptic symptoms in children with insulin-dependent diabetes mellitus and gastroparesis." | 5.10 | Domperidone is more effective than cisapride in children with diabetic gastroparesis. ( Borrelli, O; Corrado, G; Cucchiara, S; Di Nardo, G; Dito, L; Franzese, A; Grandinetti, AL; Rea, P, 2002) |
| "A double-blind, multicenter, randomized trial was conducted to compare the side effects and efficacy of domperidone and metoclopramide in symptomatic diabetic gastroparesis." | 5.09 | A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis. ( Abell, T; Barnett, J; Koch, K; Patterson, D; Rothstein, R, 1999) |
| " A diagnosis of neuroleptic malignant syndrome was made, and the patient was given dantrolene with prompt and complete resolution of all signs and symptoms." | 3.68 | Neuroleptic malignant syndrome induced by domperidone. ( Chan, W; Sachar, DB; Spirt, MJ; Thieberg, M, 1992) |
| "Domperidone was most effective in those patients with the greatest delay in gastric emptying." | 2.66 | Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy. ( Chatterton, BE; Collins, PJ; Harding, PE; Horowitz, M; Shearman, DJ, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (55.56) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fedorchenko, IuL | 1 |
| Volpi, R | 2 |
| Coiro, V | 2 |
| Castelli, A | 1 |
| Cappagli, M | 1 |
| Muzzetto, P | 1 |
| Sciarra, A | 1 |
| Chiodera, P | 2 |
| Heer, M | 1 |
| Müller-Duysing, W | 1 |
| Benes, I | 1 |
| Weitzel, M | 1 |
| Pirovino, M | 1 |
| Altorfer, J | 1 |
| Schmid, M | 1 |
| Patterson, D | 1 |
| Abell, T | 1 |
| Rothstein, R | 1 |
| Koch, K | 1 |
| Barnett, J | 1 |
| Franzese, A | 1 |
| Borrelli, O | 1 |
| Corrado, G | 1 |
| Rea, P | 1 |
| Di Nardo, G | 1 |
| Grandinetti, AL | 1 |
| Dito, L | 1 |
| Cucchiara, S | 1 |
| Spirt, MJ | 1 |
| Chan, W | 1 |
| Thieberg, M | 1 |
| Sachar, DB | 1 |
| Koch, KL | 1 |
| Stern, RM | 1 |
| Stewart, WR | 1 |
| Vasey, MW | 1 |
| Butturini, U | 1 |
| Gnudi, A | 1 |
| d'Amato, L | 1 |
| Speroni, G | 1 |
| Capretti, L | 1 |
| Roti, E | 1 |
| Horowitz, M | 1 |
| Harding, PE | 1 |
| Chatterton, BE | 1 |
| Collins, PJ | 1 |
| Shearman, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Pilot, Randomized, Double-blind, Placebo-controlled Trial of Promethazine for Treatment of Diabetic Gastroparesis.[NCT02130622] | Phase 2 | 3 participants (Actual) | Interventional | 2014-07-31 | Terminated (stopped due to Lack of recruitment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for domperidone and Autoimmune Diabetes
| Article | Year |
|---|---|
[Comparative data of prokinetics in treatment of gastroesophageal reflux disease in patients with diabetes].
Topics: Adult; Benzamides; Benzyl Compounds; Diabetes Complications; Diabetes Mellitus, Type 1; Diabetes Mel | 2013 |
Diabetic gastroparesis: treatment with domperidone--a double-blind, placebo-controlled trial.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Domperidone; Double-Blind Method; Female; Gastric Emptying; | 1983 |
A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis.
Topics: Adult; Aged; Antiemetics; Diabetes Mellitus, Type 1; Domperidone; Dopamine Antagonists; Double-Blind | 1999 |
Domperidone is more effective than cisapride in children with diabetic gastroparesis.
Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cisapride; Diabetes Mellitus, Type 1; Dom | 2002 |
Acute and chronic effects of domperidone on gastric emptying in diabetic autonomic neuropathy.
Topics: Adult; Autonomic Nervous System Diseases; Blood Glucose; Diabetes Mellitus, Type 1; Diabetic Neuropa | 1985 |
4 other studies available for domperidone and Autoimmune Diabetes
| Article | Year |
|---|---|
Different effects of metoclopramide and domperidone on GH release in type I male diabetics.
Topics: Adult; Blood-Brain Barrier; Diabetes Mellitus, Type 1; Domperidone; Dopamine; Growth Hormone; Humans | 1984 |
Neuroleptic malignant syndrome induced by domperidone.
Topics: Dantrolene; Diabetes Mellitus, Type 1; Domperidone; Female; Humans; Malignant Hyperthermia; Middle A | 1992 |
Gastric emptying and gastric myoelectrical activity in patients with diabetic gastroparesis: effect of long-term domperidone treatment.
Topics: Adult; Aged; Diabetes Mellitus, Type 1; Domperidone; Electrophysiology; Female; Gastric Emptying; Hu | 1989 |
TSH and PRL responses to domperidone and TRH in men with insulin-dependent diabetes mellitus of different duration.
Topics: Adult; Diabetes Mellitus, Type 1; Domperidone; Dopamine; Humans; Male; Pituitary Gland; Prolactin; R | 1987 |