domperidone has been researched along with Air Sickness in 5 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "L-sulpiride, at a dose of 4 mg/kg, essentially abolished motion-induced emesis in a group of 6 squirrel monkeys undergoing horizontal rotation at 25 rpm, a terrestrial model of space motion sickness (SMS)." | 7.67 | The anti-emetic properties of 1-sulpiride in a ground-based model of space motion sickness. ( Brizzee, KR; Miller, JD, 1987) |
| "Our aims were to investigate the dominant frequency and regularity of gastric myoelectrical activity during motion sickness induced with the advanced spatial disorientation demonstrator (ASDD) and to evaluate the effect of domperidone on gastric myoelectrical activity and gastrointestinal symptoms during motion sickness." | 3.70 | Impaired gastric slow waves induced by spatial disorientation and effect of domperidone. ( Chen, JD; Kono, T; Mizumoto, C; Tatsuno, J; Tokumaru, O, 1999) |
| "L-sulpiride, at a dose of 4 mg/kg, essentially abolished motion-induced emesis in a group of 6 squirrel monkeys undergoing horizontal rotation at 25 rpm, a terrestrial model of space motion sickness (SMS)." | 3.67 | The anti-emetic properties of 1-sulpiride in a ground-based model of space motion sickness. ( Brizzee, KR; Miller, JD, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Jiang, ZL | 1 |
| Wang, GH | 1 |
| Fan, JW | 1 |
| Takeda, N | 1 |
| Hasegawa, S | 1 |
| Morita, M | 1 |
| Horii, A | 1 |
| Uno, A | 1 |
| Yamatodani, A | 1 |
| Matsunaga, T | 1 |
| Kono, T | 1 |
| Tokumaru, O | 1 |
| Mizumoto, C | 1 |
| Tatsuno, J | 1 |
| Chen, JD | 1 |
| Oosterveld, WJ | 1 |
| Miller, JD | 1 |
| Brizzee, KR | 1 |
2 trials available for domperidone and Air Sickness
| Article | Year |
|---|---|
Plasma vasopressin, an etiologic factor of motion sickness in rat and human?
Topics: Adult; Animals; Domperidone; Dopamine Antagonists; Female; Flunarizine; Humans; Male; Motion Sicknes | 2005 |
The combined effect of cinnarizine and domperidone on vestibular susceptibility.
Topics: Administration, Oral; Adult; Cinnarizine; Domperidone; Double-Blind Method; Drug Combinations; Femal | 1987 |
3 other studies available for domperidone and Air Sickness
| Article | Year |
|---|---|
Neuropharmacological mechanisms of emesis. I. Effects of antiemetic drugs on motion- and apomorphine-induced pica in rats.
Topics: Animals; Antiemetics; Apomorphine; Diphenhydramine; Domperidone; Eating; Kaolin; Male; Motion Sickne | 1995 |
Impaired gastric slow waves induced by spatial disorientation and effect of domperidone.
Topics: Adult; Antiemetics; Domperidone; Dopamine Antagonists; Electromyography; Female; Humans; Male; Middl | 1999 |
The anti-emetic properties of 1-sulpiride in a ground-based model of space motion sickness.
Topics: Animals; Antiemetics; Chlorpromazine; Disease Models, Animal; Domperidone; Female; Male; Motion Sick | 1987 |