domperidone has been researched along with Adverse Drug Event in 10 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine whether oral domperidone is associated with QT interval prolongation and ventricular arrhythmia and to identify factors that can influence these effects." | 3.74 | Effect of domperidone on QT interval in neonates. ( Djeddi, D; Kongolo, G; Lefaix, C; Léké, A; Mounard, J, 2008) |
| "In 2014, the Korean Ministry of Food and Drug Safety (MFDS) issued a safety warning to carefully consider adverse cardiac effects when prescribing domperidone for children." | 1.56 | Domperidone prescribing patterns in pediatric patients before and after safety warning in South Korea. ( Goodin, AJ; Han, N; Oh, JM; Rhew, K, 2020) |
| "Domperidone was found to be associated with multiple AEs." | 1.51 | Prescription pattern & adverse drug reactions of prokinetics. ( Bhatia, SJ; Biswas, M; Ingawale, S; Koli, PG; Shetty, YC; Singh, KNM, 2019) |
| "Pioglitazone was further assessed as a mechanism-based inhibitor." | 1.40 | Domperidone interacts with pioglitazone but not with ondansetron via common CYP metabolism in vitro. ( Nagar, S; Parkman, HP; Youssef, AS, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (10.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (30.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 1 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Biswas, M | 1 |
| Singh, KNM | 1 |
| Shetty, YC | 1 |
| Koli, PG | 1 |
| Ingawale, S | 1 |
| Bhatia, SJ | 1 |
| Rhew, K | 1 |
| Han, N | 1 |
| Goodin, AJ | 1 |
| Oh, JM | 1 |
| Youssef, AS | 1 |
| Parkman, HP | 1 |
| Nagar, S | 1 |
| Bashashati, M | 1 |
| Sarosiek, I | 1 |
| Siddiqui, T | 1 |
| McCallum, RW | 2 |
| Djeddi, D | 1 |
| Kongolo, G | 1 |
| Lefaix, C | 1 |
| Mounard, J | 1 |
| Léké, A | 1 |
| Hennessy, S | 1 |
| Leonard, CE | 1 |
| Palumbo, CM | 1 |
| Bilker, WB | 1 |
| Newcomb, C | 1 |
| Kimmel, SE | 1 |
| Collins, KK | 1 |
| Sondheimer, JM | 1 |
| Ricci, DA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Clinical Trial: Use of Domperidone to Increase Milk Production in Mothers With Newborns Hospitalized in Neonatology[NCT03221855] | Early Phase 1 | 30 participants (Actual) | Interventional | 2013-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for domperidone and Adverse Drug Event
| Article | Year |
|---|---|
Diagnosis and treatment of delayed gastric emptying.
Topics: Anemia, Pernicious; Anorexia Nervosa; Cisapride; Connective Tissue Diseases; Diabetes Complications; | 1988 |
9 other studies available for domperidone and Adverse Drug Event
| Article | Year |
|---|---|
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Prescription pattern & adverse drug reactions of prokinetics.
Topics: Adult; Domperidone; Drug-Related Side Effects and Adverse Reactions; Female; Humans; India; Male; Mi | 2019 |
Domperidone prescribing patterns in pediatric patients before and after safety warning in South Korea.
Topics: Adolescent; Child; Domperidone; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; | 2020 |
Domperidone interacts with pioglitazone but not with ondansetron via common CYP metabolism in vitro.
Topics: Antiemetics; Chromatography, Liquid; Cytochrome P-450 CYP3A; Domperidone; Drug Interactions; Drug-Re | 2014 |
Adverse Effects of Domperidone: Prolonged QuesT for Knowledge?
Topics: Domperidone; Drug-Related Side Effects and Adverse Reactions; Humans | 2016 |
Effect of domperidone on QT interval in neonates.
Topics: Administration, Oral; Arrhythmias, Cardiac; Domperidone; Dopamine Antagonists; Drug-Related Side Eff | 2008 |
Diagnostic codes for sudden cardiac death and ventricular arrhythmia functioned poorly to identify outpatient events in EPIC's General Practice Research Database.
Topics: Arrhythmias, Cardiac; Cisapride; Cohort Studies; Databases, Factual; Death, Sudden, Cardiac; Domperi | 2008 |
Domperidone-induced QT prolongation: add another drug to the list.
Topics: Animals; Cisapride; Domperidone; Dopamine Antagonists; Drug-Related Side Effects and Adverse Reactio | 2008 |