domperidone has been researched along with Acute Disease in 20 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this randomized, double-blind, phase 3 study, children ages 6 months to 12 years with acute gastroenteritis randomly (1:1) received oral domperidone 0." | 9.30 | Safety and Efficacy of Low-dose Domperidone for Treating Nausea and Vomiting Due to Acute Gastroenteritis in Children. ( Appiani, C; Garces-Sanchez, M; Gupta, R; Hu, P; Leitz, G; Li, Q; Mitha, E, 2019) |
| "Domperidone is an antiemetic that is often prescribed for children with acute gastroenteritis in Japan." | 9.20 | Domperidone with ORT in the treatment of pediatric acute gastroenteritis in Japan: a multicenter, randomized controlled trial. ( Hinotsu, S; Kawakami, K; Kishida, K; Kita, F; Nakahata, T; Sasaki, H; Shimakawa, T; Urushihara, H; Wakazono, Y; Yamauchi, E; Yorifuji, T, 2015) |
| "To compare the efficacy of ondansetron and domperidone for the symptomatic treatment of vomiting in children with AG who have failed ORT." | 9.15 | Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial. ( Arrighini, A; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Di Pietro, P; Guala, A; Maestro, A; Mannelli, F; Marchetti, F; Messi, G; Pazzaglia, A; Perri, F; Reale, A; Renna, S; Ronfani, L; Rovere, F; Tondelli, MT; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2011) |
| "Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis." | 6.82 | Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial. ( Arrighini, A; Barbi, E; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Guala, A; Maestro, A; Marchetti, F; Mazzoni, E; Pazzaglia, A; Perri, PF; Reale, A; Renna, S; Ronfani, L; Rovere, F; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2016) |
| "In this randomized, double-blind, phase 3 study, children ages 6 months to 12 years with acute gastroenteritis randomly (1:1) received oral domperidone 0." | 5.30 | Safety and Efficacy of Low-dose Domperidone for Treating Nausea and Vomiting Due to Acute Gastroenteritis in Children. ( Appiani, C; Garces-Sanchez, M; Gupta, R; Hu, P; Leitz, G; Li, Q; Mitha, E, 2019) |
| "Domperidone is an antiemetic that is often prescribed for children with acute gastroenteritis in Japan." | 5.20 | Domperidone with ORT in the treatment of pediatric acute gastroenteritis in Japan: a multicenter, randomized controlled trial. ( Hinotsu, S; Kawakami, K; Kishida, K; Kita, F; Nakahata, T; Sasaki, H; Shimakawa, T; Urushihara, H; Wakazono, Y; Yamauchi, E; Yorifuji, T, 2015) |
| "To compare the efficacy of ondansetron and domperidone for the symptomatic treatment of vomiting in children with AG who have failed ORT." | 5.15 | Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial. ( Arrighini, A; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Di Pietro, P; Guala, A; Maestro, A; Mannelli, F; Marchetti, F; Messi, G; Pazzaglia, A; Perri, F; Reale, A; Renna, S; Ronfani, L; Rovere, F; Tondelli, MT; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2011) |
| " Ondansetron revealed the largest effect in comparison to placebo for cessation of vomiting (odds ratio = 0." | 5.05 | Antiemetics in Children With Acute Gastroenteritis: A Meta-analysis. ( Acosta-Reyes, J; Florez, ID; Niño-Serna, LF; Veroniki, AA, 2020) |
| "Inflammatory edema was induced by carrageenan in male rats, and hyperprolactinemia was induced by injections of the dopamine receptor antagonist domperidone." | 3.76 | Acute and chronic stress and the inflammatory response in hyperprolactinemic rats. ( Carvalho-Freitas, MI; Cruz-Casallas, PE; Felicio, LF; Malucelli, BE; Nasello, AG; Ochoa-Amaya, JE, 2010) |
| " Peripheral chemoreceptor effects on ventilation were evaluated by exposing animals to hyperoxia (Dejours test) and domperidone, a peripheral ventilatory stimulant drug directly affecting the carotid sinus nerve discharge." | 3.74 | Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice. ( Borter, E; Gassmann, M; Soliz, J; Soulage, C; van Patot, MT, 2008) |
| "Two girls, aged 2 and 4 years, with acute gastroenteritis and vomiting, received domperidone and metoclopramide, respectively." | 3.73 | [Urinary retention in 2 children after the use of antiemetic agents during acute gastroenteritis]. ( de Moor, RA; Diemont, WL; van den Bemt, PM; Visser, MO, 2005) |
| "The influence of the dopamine receptor-stimulating agent, bromocriptine, the dopamine-releasing drug, amantadine, and the dopamine antagonist, domperidone, on acute pancreatitis was studied in rats." | 3.67 | The influence of dopamine receptor agonists and an antagonist on acute pancreatitis in rats. ( Geber, J; Gjuris, V; Jagić, V; Krizanac, S; Mise, S; Petek, M; Rotkvić, I; Sikirić, P; Suchanek, E; Udovicić, I, 1988) |
| "Domperidone was not effective for the symptomatic treatment of vomiting during acute gastroenteritis." | 2.82 | Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial. ( Arrighini, A; Barbi, E; Bertolani, P; Biban, P; Bonati, M; Clavenna, A; Da Dalt, L; Guala, A; Maestro, A; Marchetti, F; Mazzoni, E; Pazzaglia, A; Perri, PF; Reale, A; Renna, S; Ronfani, L; Rovere, F; Urbino, AF; Valletta, E; Vitale, A; Zangardi, T; Zanon, D, 2016) |
| "Functional vomiting is rare and presents with more frequent vomiting episodes." | 2.44 | Functional nausea and vomiting. ( Talley, NJ, 2007) |
| "Antiemetics are not included for treatment of vomiting associated with acute gastroenteritis (AGE) in children by standard guidelines." | 1.33 | Antiemetics for children with gastroenteritis: off-label but still on in clinical practice. ( Albano, F; Bruzzese, E; De Marco, G; Spagnuolo, MI, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (20.00) | 18.7374 |
| 1990's | 2 (10.00) | 18.2507 |
| 2000's | 7 (35.00) | 29.6817 |
| 2010's | 6 (30.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Niño-Serna, LF | 1 |
| Acosta-Reyes, J | 1 |
| Veroniki, AA | 1 |
| Florez, ID | 1 |
| Leitz, G | 1 |
| Hu, P | 1 |
| Appiani, C | 1 |
| Li, Q | 1 |
| Mitha, E | 1 |
| Garces-Sanchez, M | 1 |
| Gupta, R | 1 |
| Coloma, PM | 1 |
| Schuemie, MJ | 1 |
| Trifirò, G | 1 |
| Furlong, L | 1 |
| van Mulligen, E | 1 |
| Bauer-Mehren, A | 1 |
| Avillach, P | 1 |
| Kors, J | 1 |
| Sanz, F | 1 |
| Mestres, J | 1 |
| Oliveira, JL | 1 |
| Boyer, S | 1 |
| Helgee, EA | 1 |
| Molokhia, M | 1 |
| Matthews, J | 1 |
| Prieto-Merino, D | 1 |
| Gini, R | 1 |
| Herings, R | 1 |
| Mazzaglia, G | 1 |
| Picelli, G | 1 |
| Scotti, L | 1 |
| Pedersen, L | 1 |
| van der Lei, J | 1 |
| Sturkenboom, M | 1 |
| Marchetti, F | 2 |
| Bonati, M | 2 |
| Maestro, A | 2 |
| Zanon, D | 2 |
| Rovere, F | 2 |
| Arrighini, A | 2 |
| Barbi, E | 1 |
| Bertolani, P | 2 |
| Biban, P | 2 |
| Da Dalt, L | 2 |
| Guala, A | 2 |
| Mazzoni, E | 1 |
| Pazzaglia, A | 2 |
| Perri, PF | 1 |
| Reale, A | 2 |
| Renna, S | 2 |
| Urbino, AF | 2 |
| Valletta, E | 2 |
| Vitale, A | 2 |
| Zangardi, T | 2 |
| Clavenna, A | 2 |
| Ronfani, L | 2 |
| Soliz, J | 1 |
| Soulage, C | 1 |
| Borter, E | 1 |
| van Patot, MT | 1 |
| Gassmann, M | 1 |
| Kumar, Y | 1 |
| Sarvananthan, R | 1 |
| Ochoa-Amaya, JE | 1 |
| Malucelli, BE | 1 |
| Cruz-Casallas, PE | 1 |
| Nasello, AG | 1 |
| Felicio, LF | 1 |
| Carvalho-Freitas, MI | 1 |
| Di Pietro, P | 1 |
| Mannelli, F | 1 |
| Messi, G | 1 |
| Perri, F | 1 |
| Tondelli, MT | 1 |
| Kita, F | 1 |
| Hinotsu, S | 1 |
| Yorifuji, T | 1 |
| Urushihara, H | 1 |
| Shimakawa, T | 1 |
| Kishida, K | 1 |
| Wakazono, Y | 1 |
| Yamauchi, E | 1 |
| Sasaki, H | 1 |
| Nakahata, T | 1 |
| Kawakami, K | 1 |
| de Moor, RA | 1 |
| Diemont, WL | 1 |
| Visser, MO | 1 |
| van den Bemt, PM | 1 |
| Albano, F | 1 |
| Bruzzese, E | 1 |
| Spagnuolo, MI | 1 |
| De Marco, G | 1 |
| Talley, NJ | 1 |
| Franckx, J | 1 |
| Noel, P | 1 |
| Bee, D | 1 |
| Pallot, DJ | 1 |
| Nguyen, J | 1 |
| Sibille, G | 1 |
| Cazassus, F | 1 |
| Baba, N | 1 |
| Atallah, A | 1 |
| Coriatt, D | 1 |
| Lang, AE | 1 |
| Nerozzi, D | 1 |
| Magnani, A | 1 |
| Sforza, V | 1 |
| Scaramucci, E | 1 |
| Cerilli, M | 1 |
| Moretti, C | 1 |
| Frajese, G | 1 |
| Antonozzi, I | 1 |
| Meltzer, HY | 1 |
| Sikirić, P | 1 |
| Rotkvić, I | 1 |
| Mise, S | 1 |
| Krizanac, S | 1 |
| Gjuris, V | 1 |
| Jagić, V | 1 |
| Suchanek, E | 1 |
| Petek, M | 1 |
| Udovicić, I | 1 |
| Geber, J | 1 |
| Madej, TH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Double-blind, Randomized, Placebo-controlled, Parallel-group, Prospective Study to Evaluate the Safety and Efficacy of Domperidone in 6-month-old to 12-year-old Pediatric Subjects With Nausea and Vomiting Due to Acute Gastroenteritis[NCT02699385] | Phase 3 | 10 participants (Actual) | Interventional | 2015-12-07 | Terminated (stopped due to Study prematurely terminated upon recommendation of IDMC due to lack of efficacy.) | ||
| Oral Ondansetron vs Domperidone for Symptomatic Treatment of Vomiting During Acute Gastroenteritis in Children: Multicentre Randomized Controlled Trial[NCT01257672] | Phase 3 | 356 participants (Actual) | Interventional | 2011-07-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for domperidone and Acute Disease
| Article | Year |
|---|---|
Antiemetics in Children With Acute Gastroenteritis: A Meta-analysis.
Topics: Acute Disease; Antiemetics; Child; Child, Preschool; Dexamethasone; Diarrhea; Dimenhydrinate; Domper | 2020 |
GORD in children.
Topics: Acute Disease; Administration, Oral; Child; Cross-Sectional Studies; Domperidone; Gastroesophageal R | 2008 |
Functional nausea and vomiting.
Topics: Acute Disease; Antidepressive Agents, Tricyclic; Antiemetics; Chronic Disease; Diagnosis, Differenti | 2007 |
4 trials available for domperidone and Acute Disease
| Article | Year |
|---|---|
Safety and Efficacy of Low-dose Domperidone for Treating Nausea and Vomiting Due to Acute Gastroenteritis in Children.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Domperidone; Double-Blind | 2019 |
Oral Ondansetron versus Domperidone for Acute Gastroenteritis in Pediatric Emergency Departments: Multicenter Double Blind Randomized Controlled Trial.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Domperidone; Double-Blind | 2016 |
Oral ondansetron versus domperidone for symptomatic treatment of vomiting during acute gastroenteritis in children: multicentre randomized controlled trial.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Clinical Protocols; Dompe | 2011 |
Domperidone with ORT in the treatment of pediatric acute gastroenteritis in Japan: a multicenter, randomized controlled trial.
Topics: Acute Disease; Administration, Oral; Antiemetics; Child; Child, Preschool; Domperidone; Drug Therapy | 2015 |
13 other studies available for domperidone and Acute Disease
| Article | Year |
|---|---|
Drug-induced acute myocardial infarction: identifying 'prime suspects' from electronic healthcare records-based surveillance system.
Topics: Acute Disease; Adverse Drug Reaction Reporting Systems; Azithromycin; Betamethasone; Cisapride; Domp | 2013 |
Ventilatory responses to acute and chronic hypoxia are altered in female but not male Paskin-deficient mice.
Topics: Acclimatization; Acute Disease; Animals; Body Temperature; Carotid Body; Chronic Disease; Disease Mo | 2008 |
Acute and chronic stress and the inflammatory response in hyperprolactinemic rats.
Topics: Acute Disease; Animals; Carrageenan; Chronic Disease; Cold Temperature; Disease Models, Animal; Domp | 2010 |
[Urinary retention in 2 children after the use of antiemetic agents during acute gastroenteritis].
Topics: Acute Disease; Antiemetics; Child, Preschool; Domperidone; Dopamine Antagonists; Female; Gastroenter | 2005 |
Antiemetics for children with gastroenteritis: off-label but still on in clinical practice.
Topics: Acute Disease; Administration, Rectal; Antiemetics; Child, Preschool; Domperidone; Gastroenteritis; | 2006 |
Acute extrapyramidal dysfunction after domperidone administration. Report of a case.
Topics: Acute Disease; Basal Ganglia Diseases; Child, Preschool; Domperidone; Humans; Male | 1984 |
Acute hypoxic ventilation, carotid body cell division, and dopamine content during early hypoxia in rats.
Topics: Acute Disease; Animals; Autoradiography; Carotid Body; Cell Division; Domperidone; Dopamine; Dopamin | 1995 |
[Acute extrapyramidal manifestations caused by domperidone].
Topics: Acute Disease; Antiemetics; Basal Ganglia Diseases; Domperidone; Humans; Infant; Male | 2000 |
Acute orthostatic hypotension when starting dopamine agonist therapy in parkinson disease: the role of domperidone therapy.
Topics: Acute Disease; Domperidone; Dopamine Agonists; Dopamine Antagonists; Humans; Hypotension, Orthostati | 2001 |
Plasma prolactin response to domperidone in acute schizophrenia and schizophreniform illness.
Topics: Acute Disease; Adult; Brain; Domperidone; Humans; Male; Military Personnel; Prolactin; Psychotic Dis | 1990 |
The influence of dopamine receptor agonists and an antagonist on acute pancreatitis in rats.
Topics: Acute Disease; Amantadine; Amylases; Animals; Bromocriptine; Domperidone; Female; Male; Pancreas; Pa | 1988 |
Domperidone: an alternative to metoclopramide.
Topics: Acute Disease; Adolescent; Adult; Child; Domperidone; Humans; Metoclopramide; Nausea; Vomiting | 1988 |
Domperidone--an acute dystonic reaction.
Topics: Acute Disease; Adult; Domperidone; Dystonia; Female; Humans | 1985 |