domperidone has been researched along with Acromegaly in 7 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Acromegaly: A condition caused by prolonged exposure to excessive HUMAN GROWTH HORMONE in adults. It is characterized by bony enlargement of the FACE; lower jaw (PROGNATHISM); hands; FEET; HEAD; and THORAX. The most common etiology is a GROWTH HORMONE-SECRETING PITUITARY ADENOMA. (From Joynt, Clinical Neurology, 1992, Ch36, pp79-80)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone did not increase PRL in about a third of acromegalic patients, while TRH increased PRL in the all normoprolactinemic acromegalic patients." | 1.27 | Disturbed prolactin responses to dopamine-related substances in patients with acromegaly and hyperprolactinemia. ( Ibayashi, H; Ikuyama, S; Karashima, T; Kato, K; Muta, K; Sekiya, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hanew, K | 2 |
| Sato, S | 2 |
| Sasaki, A | 2 |
| Kasai, M | 1 |
| Shimizu, Y | 1 |
| Murakami, O | 1 |
| Yoshinaga, K | 2 |
| Müller, EE | 2 |
| Cavagnini, F | 1 |
| Martinez-Campos, A | 1 |
| Maraschini, C | 1 |
| Giovannini, P | 1 |
| Novelli, A | 1 |
| De Leo, V | 1 |
| Prescott, RW | 1 |
| Weightman, DR | 1 |
| Kendall-Taylor, P | 1 |
| Johnston, DG | 1 |
| Tater, D | 1 |
| Maudelonde, T | 1 |
| Sudre, Y | 1 |
| Besson, G | 1 |
| Bercovici, JP | 1 |
| Camanni, F | 1 |
| Massara, F | 1 |
| Santià , M | 1 |
| Molinatti, GM | 1 |
| Goh, M | 1 |
| Sekiya, K | 1 |
| Karashima, T | 1 |
| Ikuyama, S | 1 |
| Muta, K | 1 |
| Kato, K | 1 |
| Ibayashi, H | 1 |
1 trial available for domperidone and Acromegaly
| Article | Year |
|---|---|
Differential TSH and PRL responses to dopamine receptor blockade in acromegaly.
Topics: Acromegaly; Adult; Domperidone; Growth Hormone; Humans; Male; Middle Aged; Prolactin; Receptors, Dop | 1984 |
6 other studies available for domperidone and Acromegaly
| Article | Year |
|---|---|
Plasma growth hormone responses to sulpiride in patients with acromegaly.
Topics: Acromegaly; Adult; Domperidone; Dopamine; Female; Growth Hormone; Humans; Hypophysectomy; Levodopa; | 1984 |
Dynamic testing of prolactin and growth hormone secretion in patients with neuroendocrine disorders.
Topics: Acromegaly; Adolescent; Adult; Aged; Brain; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Fem | 1984 |
Similar response to dopaminergic or anti-dopaminergic drugs in acromegaly.
Topics: Acromegaly; Domperidone; Female; Growth Hormone; Humans; Levodopa; Male; Receptors, Dopamine | 1984 |
Impaired prolactin responsiveness to dopamine antagonists in acromegaly.
Topics: Acromegaly; Adolescent; Adult; Domperidone; Dopamine Antagonists; Female; Growth Hormone; Humans; Ma | 1982 |
Growth hormone inhibitory and stimulatory actions of L-dopa in patients with acromegaly.
Topics: Acromegaly; Adult; Blood-Brain Barrier; Bromocriptine; Domperidone; Dopamine; Female; Growth Hormone | 1987 |
Disturbed prolactin responses to dopamine-related substances in patients with acromegaly and hyperprolactinemia.
Topics: Acromegaly; Adult; D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; Domperidone; Female; Humans; Male; Middle | 1985 |