domperidone has been researched along with Abnormalities, Autosome in 2 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Possible induction of chromosome aberrations and gene mutations by domperidone was studied in vivo respectively by a micronucleus test on female rats and a sex-linked recessive lethal test on Drosophila." | 1.27 | In vivo mutagenicity evaluation of domperidone in Drosophila germ cells and rat bone marrow cells. ( Gilot-Delhalle, J; Marsboom, R; Moutschen, J; Moutschen-Dahmen, M; Vanparys, P, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vanparys, P | 2 |
| Fabry, L | 1 |
| Leonard, A | 1 |
| Marsboom, R | 2 |
| Gilot-Delhalle, J | 1 |
| Moutschen, J | 1 |
| Moutschen-Dahmen, M | 1 |
2 other studies available for domperidone and Abnormalities, Autosome
| Article | Year |
|---|---|
Mutagenicity tests with domperidone in vitro and in vivo.
Topics: Animals; Cell Nucleus; Chromosome Aberrations; Domperidone; Erythrocytes; Liver; Mitosis; Mutagenici | 1982 |
In vivo mutagenicity evaluation of domperidone in Drosophila germ cells and rat bone marrow cells.
Topics: Animals; Bone Marrow; Chromosome Aberrations; Domperidone; Drosophila; Female; Germ Cells; In Vitro | 1985 |