domperidone has been researched along with ADPKD in 1 studies
Domperidone: A specific blocker of dopamine receptors. It speeds gastrointestinal peristalsis, causes prolactin release, and is used as antiemetic and tool in the study of dopaminergic mechanisms.
domperidone : 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Domperidone treatment increases HDAC5 phosphorylation likely by reducing protein phosphatase 2A (PP2A) activity, thus shifting the equilibrium towards HDAC5-P and export from the nucleus." | 1.51 | Dopamine receptor antagonists as potential therapeutic agents for ADPKD. ( Conkright-Fincham, J; Li, R; Paul, P; Ramachandran, S; Unruh, JR; Xia, S, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paul, P | 1 |
| Ramachandran, S | 1 |
| Xia, S | 1 |
| Unruh, JR | 1 |
| Conkright-Fincham, J | 1 |
| Li, R | 1 |
1 other study available for domperidone and ADPKD
| Article | Year |
|---|---|
Dopamine receptor antagonists as potential therapeutic agents for ADPKD.
Topics: Active Transport, Cell Nucleus; Animals; Cell Proliferation; Domperidone; Dopamine Antagonists; Drug | 2019 |