domoic-acid has been researched along with Brain-Damage--Chronic* in 2 studies
2 review(s) available for domoic-acid and Brain-Damage--Chronic
| Article | Year |
|---|---|
Intrauterine environment-genome interaction and children's development (2): Brain structure impairment and behavioral disturbance induced in male mice offspring by a single intraperitoneal administration of domoic acid (DA) to their dams.
To demonstrate induction of delayed central nervous toxicity by disturbing neuronal activities in the developing brain, we administered a single intraperitoneal dose of domoic acid (DA; 1 mg/kg), a potent glutamate receptor agonist, to pregnant female mice at the gestational day of 11.5, 14.5 or 17.5. The dams had recovered from acute symptoms within 24 hr, followed by normal delivery, feeding and weaning. All male offspring mice after weaning were apparently normal in response to handlers during cage maintenance, body weight measurement and to mate mice in group housing conditions. At the age of 11 weeks, our neurobehavior testing battery revealed severe impairment of learning and memory with serious deviances of anxiety-related behaviors. The developed brain of prenatally exposed mice showed myelination failure and the overgrowth of neuronal processes of the limbic cortex neurons. This study indicates that the temporal disturbance of neurotransmission of the developing brain induces irreversible structural and functional damage to offspring which becomes monitorable in their adulthood by a proper battery of neurobehavioral tests. Topics: Animals; Anxiety Disorders; Brain; Brain Damage, Chronic; Demyelinating Diseases; Excitatory Amino Acid Agonists; Female; Injections, Intraperitoneal; Kainic Acid; Learning Disabilities; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Morphogenesis; Pregnancy; Prenatal Exposure Delayed Effects; Synaptic Transmission | 2009 |
Neurotoxins and environmental poisons.
Recent applications of modern neurobiological techniques have provided an impetus to understanding mechanisms of neurotoxicity. Environmental chemicals, including aluminium, and the organocompounds of mercury, lead and tin, may trigger neurodegenerative disorders. Regional differences in toxicity may be related to the complexity of the amino acid excitatory systems and the ability of individual cell systems to handle long-term abusive stimulation. Topics: Animals; Brain; Brain Damage, Chronic; Environmental Exposure; Humans; Kainic Acid; Neuromuscular Diseases; Neurotoxins; Organometallic Compounds | 1992 |