dolichols and Mental-Disorders

dolichols has been researched along with Mental-Disorders* in 2 studies

Other Studies

2 other study(ies) available for dolichols and Mental-Disorders

ArticleYear
Isoprenoid pathway-related membrane dysfunction in neuropsychiatric disorders.
    The International journal of neuroscience, 2003, Volume: 113, Issue:11

    The membrane composition and the isoprenoid pathway metabolites important in maintaining cell membrane integrity was studied in neurological and psychiatric disorders. The results indicate alteration in cholesterol:phospholipid ratio of the RBC membrane which is increased in glioma, schizophrenia, and bipolar mood disorder (MDP); decreased in multiple sclerosis and Parkinson's disease; and not significantly altered in epilepsy. The concentration of total glycosaminoglycans (GAG), hexose, and fucose decreased in the RBC membrane and increased in the serum. The RBC membrane Na+-K+ ATPase activity was reduced and serum HMG CoA reductase activity was increased. There were increased serum levels of digoxin, cholesterol, and dolichol and decreased levels of ubiquinone. The serum magnesium and tyrosine levels were reduced and tryptophan increased. The results indicate a defect in membrane formation and a decreased membrane Na+-K+ ATPase activity in all the disorders studied. The results are discussed, and a hypothesis regarding the relationship between these disorders and defective membrane architecture and membrane Na+-K+ ATPase inhibition is presented.

    Topics: Adult; Cholesterol; Digoxin; Dolichols; Erythrocyte Membrane; Female; Humans; Hydroxymethylglutaryl CoA Reductases; Male; Membrane Proteins; Mental Disorders; Middle Aged; Models, Biological; Nervous System Diseases; Neurons; Phospholipids; Sodium-Potassium-Exchanging ATPase; Terpenes; Tryptophan; Tyrosine; Ubiquinone

2003
Hypothalamic digoxin, hemispheric dominance, and neuroimmune integration.
    The International journal of neuroscience, 2002, Volume: 112, Issue:4

    The isoprenoid pathway produces three key metabolites--digoxin (membrane Na(+)-K+ ATPase inhibitor, regulator of neurotransmitter transport, and immunomodulatory agent), dolichol (regulatory of N-glycosylation of proteins), and ubiquinone (free-radical scavenger). The pathway was assessed in systemic lupus erythematosis with neuropsychiatric manifestations, slow viral diseases (subacute sclerosing panencephalitis [SSPE], and Creutzfeldt-Jakob disease [CJD]) and patients with recurrent respiratory infections. This was also studied for comparison in patients with right hemispheric and left hemispheric dominance. The isoprenoid pathway was upregulated with increased digoxin synthesis in patients with neurolupus, SSPE, and CJD, and in those with right hemispheric dominance. The tryptophan catabolites were increased and the tyrosine catabolites reduced. In these patients the dolichol and glycoconjugate levels were elevated and lysosomal stability was reduced. The ubiquinone levels were low and free-radical levels increased in these patients. The membrane cholesterol:phospholipid ratios were increased and membrane glycoconjugates reduced. On the other hand, in patients with recurrent respiratory infection and left hemispheric dominance, the reverse patterns and hypodigoxinemia with a downregulated isoprenoid pathway were noticed. The isoprenoid pathway is important in the pathogenesis of neurolupus, CJD, SSPE, and recurrent respiratory infections. Hypothalamic digoxin and chemical hemispheric dominance play an important role in the regulation of immunity.

    Topics: Creutzfeldt-Jakob Syndrome; Digoxin; Dolichols; Erythrocyte Membrane; Functional Laterality; Glycosaminoglycans; Humans; Hydroxymethylglutaryl CoA Reductases; Hypothalamus; Lupus Erythematosus, Systemic; Mental Disorders; Neuroimmunomodulation; Recurrence; Respiratory Tract Diseases; Sodium-Potassium-Exchanging ATPase; Subacute Sclerosing Panencephalitis; Tryptophan; Tyrosine; Ubiquinone

2002
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