dolichols has been researched along with Chemical-and-Drug-Induced-Liver-Injury* in 1 studies
1 other study(ies) available for dolichols and Chemical-and-Drug-Induced-Liver-Injury
| Article | Year |
|---|---|
Inflammation-induced increases in dolichol synthesis and hydroxymethylglutaryl-coenzyme A reductase activity in mouse liver are prevented by a high-cholesterol diet but not by fasting.
The inflammatory response in mammals is characterized by the synthesis in the liver of several N-linked serum glycoproteins called acute-phase reactants. In C57BL/6J mice, turpentine-induced inflammation was accompanied by increases in 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, dolichol synthesis, and dolichyl phosphoryl mannose synthesis. Cholesterol feeding, but not fasting, prevented these inflammation-induced increases in reductase activity and dolichol synthesis. However, the rate of incorporation of [3H]mannose into total serum glycoproteins was not affected by the high-cholesterol diet, and this rate increased during acute inflammation in control and cholesterol-fed mice. Topics: Acetates; Acetic Acid; Animals; Chemical and Drug Induced Liver Injury; Cholesterol, Dietary; Diterpenes; Dolichol Monophosphate Mannose; Dolichols; Fasting; Hydroxymethylglutaryl CoA Reductases; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Microsomes, Liver; Tritium | 1984 |