dolichol-monophosphate and Glioma

dolichol-monophosphate has been researched along with Glioma* in 1 studies

Other Studies

1 other study(ies) available for dolichol-monophosphate and Glioma

Article	Year
Dolichyl phosphate, a potent inducer of apoptosis in rat glioma C6 cells. Biochemical and biophysical research communications, 1995, Nov-22, Volume: 216, Issue:3 Exposure of rat glioma C6 cells to dolichyl phosphate resulted in cell shrinkage followed by nuclear fragmentation and internucleosomal cleavage of genomic DNA, yielding ladder patterns of oligonucleosomal fragments, all characteristics of apoptosis. This phenomenon occurred in a dose and time dependent manner. Dolichol and prenol failed to induce apoptosis. The inhibitors of N-glycosylation, tunicamycin and swainsonine had no apparent effect on dolichyl phosphate-induced apoptosis. Apoptotic changes were also observed in HL-60 cells, SIRC cells and HeLa cells. Thus, dolichyl phosphate functions as a potential apoptosis inducer as well as an essential carrier lipid in the biosynthesis of N-linked glycoprotein. Topics: Animals; Apoptosis; DNA; Dolichol Phosphates; Dolichols; Electrophoresis, Agar Gel; Glioma; Glycoproteins; Glycosylation; HeLa Cells; Hemiterpenes; Humans; Kinetics; Pentanols; Rats; Swainsonine; Tumor Cells, Cultured; Tunicamycin	1995

Article

Year

Dolichyl phosphate, a potent inducer of apoptosis in rat glioma C6 cells.

Biochemical and biophysical research communications, 1995, Nov-22, Volume: 216, Issue:3

Exposure of rat glioma C6 cells to dolichyl phosphate resulted in cell shrinkage followed by nuclear fragmentation and internucleosomal cleavage of genomic DNA, yielding ladder patterns of oligonucleosomal fragments, all characteristics of apoptosis. This phenomenon occurred in a dose and time dependent manner. Dolichol and prenol failed to induce apoptosis. The inhibitors of N-glycosylation, tunicamycin and swainsonine had no apparent effect on dolichyl phosphate-induced apoptosis. Apoptotic changes were also observed in HL-60 cells, SIRC cells and HeLa cells. Thus, dolichyl phosphate functions as a potential apoptosis inducer as well as an essential carrier lipid in the biosynthesis of N-linked glycoprotein.

Topics: Animals; Apoptosis; DNA; Dolichol Phosphates; Dolichols; Electrophoresis, Agar Gel; Glioma; Glycoproteins; Glycosylation; HeLa Cells; Hemiterpenes; Humans; Kinetics; Pentanols; Rats; Swainsonine; Tumor Cells, Cultured; Tunicamycin

1995