dizocilpine-maleate and Fragile-X-Syndrome

dizocilpine-maleate has been researched along with Fragile-X-Syndrome* in 1 studies

Other Studies

1 other study(ies) available for dizocilpine-maleate and Fragile-X-Syndrome

Article	Year
β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X. Cell reports, 2017, 03-21, Volume: 18, Issue:12 Synaptic protein synthesis is essential for modification of the brain by experience and is aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause of autism and intellectual disability. Neural activity directs local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu Topics: Animals; Behavior, Animal; beta-Arrestin 2; Disease Models, Animal; Dizocilpine Maleate; Extracellular Signal-Regulated MAP Kinases; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Deletion; GTP-Binding Protein alpha Subunits, Gq-G11; Heterozygote; Hippocampus; Locomotion; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; Mutation; Neuronal Plasticity; Neurons; Protein Biosynthesis; Receptor, Metabotropic Glutamate 5; Signal Transduction	2017

Article

Year

β-Arrestin2 Couples Metabotropic Glutamate Receptor 5 to Neuronal Protein Synthesis and Is a Potential Target to Treat Fragile X.

Cell reports, 2017, 03-21, Volume: 18, Issue:12

Synaptic protein synthesis is essential for modification of the brain by experience and is aberrant in several genetically defined disorders, notably fragile X (FX), a heritable cause of autism and intellectual disability. Neural activity directs local protein synthesis via activation of metabotropic glutamate receptor 5 (mGlu

Topics: Animals; Behavior, Animal; beta-Arrestin 2; Disease Models, Animal; Dizocilpine Maleate; Extracellular Signal-Regulated MAP Kinases; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Deletion; GTP-Binding Protein alpha Subunits, Gq-G11; Heterozygote; Hippocampus; Locomotion; Male; Mice, Inbred C57BL; Molecular Targeted Therapy; Mutation; Neuronal Plasticity; Neurons; Protein Biosynthesis; Receptor, Metabotropic Glutamate 5; Signal Transduction

2017