dizocilpine-maleate and Alcohol-Amnestic-Disorder

dizocilpine-maleate has been researched along with Alcohol-Amnestic-Disorder* in 2 studies

Other Studies

2 other study(ies) available for dizocilpine-maleate and Alcohol-Amnestic-Disorder

Article	Year
NMDA receptors in frontal cortex and hippocampus of alcohol consumers. Addiction biology, 2011, Volume: 16, Issue:1 Specific binding of [³H]MK801 to N-methyl-D-aspartate (NMDA) receptors in the frontal cortex and hippocampus (CA1 and gyrus dentatus) was measured by receptor autoradiography in 16 Caucasian chronic alcohol consumers free of clinical manifestations of alcoholism, and compared with 16 Caucasian control subjects. Binding densities were not significantly different between heavy and moderate drinkers, neither between alcohol consumers that were abstinent or non-abstinent before death, nor between ethanol drinkers and controls. Continued alcohol consumption, in the absence of hepatic, neurologic or psychiatric disorders related to alcoholism, does not alter the binding properties of NMDA receptors in the brain areas studied. Topics: Aged; Alcohol Amnestic Disorder; Autoradiography; CA1 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Frontal Lobe; Hippocampus; Humans; Male; Middle Aged; Receptors, N-Methyl-D-Aspartate	2011
MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats. Behavioral neuroscience, 1992, Volume: 106, Issue:4 Rats were trained on a spatial delayed-nonmatching-to-sample (DNMTS) task and assigned by block randomization to one of four treatments: pyrithiamine-induced thiamine deficiency (PTD), PTD with administration of MK-801 after 12 days, control with MK-801 treatment, and control without MK-801. After 15 days of treatment followed by 21 days of recovery, the PTD rats showed significant deficits for DNMTS accuracy at retention intervals (RI) that ranged from 3.0 s to 15.0 s, the RIs that produced 75% accuracy on DNMTS in staircase training, and the rate at which a novel radial arm maze task was learned. The PTD-treated rats had consistent lesions in the thalamus and the mammillary bodies. MK-801 protected rats from both behavioral deficits and brain lesions (assessed quantitatively and qualitatively) that were produced by the PTD treatment. Topics: Alcohol Amnestic Disorder; Animals; Appetitive Behavior; Brain Mapping; Discrimination Learning; Dizocilpine Maleate; Male; Mental Recall; Orientation; Pyrithiamine; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Thalamus; Thiamine Deficiency; Wernicke Encephalopathy	1992

Article

Year

NMDA receptors in frontal cortex and hippocampus of alcohol consumers.

Addiction biology, 2011, Volume: 16, Issue:1

Specific binding of [³H]MK801 to N-methyl-D-aspartate (NMDA) receptors in the frontal cortex and hippocampus (CA1 and gyrus dentatus) was measured by receptor autoradiography in 16 Caucasian chronic alcohol consumers free of clinical manifestations of alcoholism, and compared with 16 Caucasian control subjects. Binding densities were not significantly different between heavy and moderate drinkers, neither between alcohol consumers that were abstinent or non-abstinent before death, nor between ethanol drinkers and controls. Continued alcohol consumption, in the absence of hepatic, neurologic or psychiatric disorders related to alcoholism, does not alter the binding properties of NMDA receptors in the brain areas studied.

Topics: Aged; Alcohol Amnestic Disorder; Autoradiography; CA1 Region, Hippocampal; Dentate Gyrus; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Female; Frontal Lobe; Hippocampus; Humans; Male; Middle Aged; Receptors, N-Methyl-D-Aspartate

2011

MK-801 prevents brain lesions and delayed-nonmatching-to-sample deficits produced by pyrithiamine-induced encephalopathy in rats.

Behavioral neuroscience, 1992, Volume: 106, Issue:4

Rats were trained on a spatial delayed-nonmatching-to-sample (DNMTS) task and assigned by block randomization to one of four treatments: pyrithiamine-induced thiamine deficiency (PTD), PTD with administration of MK-801 after 12 days, control with MK-801 treatment, and control without MK-801. After 15 days of treatment followed by 21 days of recovery, the PTD rats showed significant deficits for DNMTS accuracy at retention intervals (RI) that ranged from 3.0 s to 15.0 s, the RIs that produced 75% accuracy on DNMTS in staircase training, and the rate at which a novel radial arm maze task was learned. The PTD-treated rats had consistent lesions in the thalamus and the mammillary bodies. MK-801 protected rats from both behavioral deficits and brain lesions (assessed quantitatively and qualitatively) that were produced by the PTD treatment.

Topics: Alcohol Amnestic Disorder; Animals; Appetitive Behavior; Brain Mapping; Discrimination Learning; Dizocilpine Maleate; Male; Mental Recall; Orientation; Pyrithiamine; Rats; Reaction Time; Receptors, N-Methyl-D-Aspartate; Retention, Psychology; Thalamus; Thiamine Deficiency; Wernicke Encephalopathy

1992