disulfiram has been researched along with Pituitary Neoplasms in 2 studies
Pituitary Neoplasms: Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "O6-methylguanine-DNA methyltransferase (MGMT) activity is responsible for temozolomide (TMZ) resistance in patients harboring aggressive pituitary adenomas." | 7.81 | Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression. ( Chen, W; Fan, B; Li, T; Xiao, Z; Yang, J; Zhao, Y, 2015) |
| "O6-methylguanine-DNA methyltransferase (MGMT) activity is responsible for temozolomide (TMZ) resistance in patients harboring aggressive pituitary adenomas." | 3.81 | Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression. ( Chen, W; Fan, B; Li, T; Xiao, Z; Yang, J; Zhao, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhao, Y | 1 |
| Xiao, Z | 1 |
| Chen, W | 1 |
| Yang, J | 1 |
| Li, T | 1 |
| Fan, B | 1 |
| Mains, RE | 1 |
| Park, LP | 1 |
| Eipper, BA | 1 |
2 other studies available for disulfiram and Pituitary Neoplasms
| Article | Year |
|---|---|
Disulfiram sensitizes pituitary adenoma cells to temozolomide by regulating O6-methylguanine-DNA methyltransferase expression.
Topics: AC133 Antigen; Acetaldehyde Dehydrogenase Inhibitors; Adenoma; Animals; Antigens, CD; Antineoplastic | 2015 |
Inhibition of peptide amidation by disulfiram and diethyldithiocarbamate.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Copper; Disulfiram; Ditiocarb; Dose-Respon | 1986 |