disulfiram has been researched along with Parkinson Disease in 8 studies
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " A toxic product of lipid peroxidation, (±)-4-hydroxy-2E-nonenal (HNE) leads to membrane disruption and formation of HNE-protein adducts and such adducts have been detected in PD brain tissues." | 1.38 | Modulation of aldehyde dehydrogenase activity affects (±)-4-hydroxy-2E-nonenal (HNE) toxicity and HNE-protein adduct levels in PC12 cells. ( Kong, D; Kotraiah, V, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kong, D | 1 |
| Kotraiah, V | 1 |
| Charles, V | 1 |
| Boulvin, S | 1 |
| Haven, F | 1 |
| Gille, M | 1 |
| Arushanian, EB | 1 |
| Birket-Smith, E | 1 |
| Andersen, JV | 1 |
| Presthus, J | 1 |
| Bianchine, JR | 1 |
| Sunyapridakul, L | 1 |
| Duvoisin, RC | 1 |
| Marsden, CD | 1 |
| Braham, J | 1 |
2 reviews available for disulfiram and Parkinson Disease
| Article | Year |
|---|---|
[Other trials with drug therapy in parkinsonism].
Topics: 5-Hydroxytryptophan; Amitriptyline; Animals; Dihydroxyphenylalanine; Disulfiram; Drug Evaluation; Dr | 1973 |
Individualization of levodopa therapy.
Topics: Amantadine; Amphetamine; Anesthetics; Animals; Antihypertensive Agents; Apomorphine; Arrhythmias, Ca | 1974 |
6 other studies available for disulfiram and Parkinson Disease
| Article | Year |
|---|---|
Modulation of aldehyde dehydrogenase activity affects (±)-4-hydroxy-2E-nonenal (HNE) toxicity and HNE-protein adduct levels in PC12 cells.
Topics: Aldehyde Dehydrogenase 1 Family; Aldehydes; Animals; Cell Death; Disulfiram; DNA Adducts; Lipid Pero | 2012 |
[Wernicke's encephalopathy associated with chronic disulfiram intoxication].
Topics: Adult; Disulfiram; Humans; Magnetic Resonance Imaging; Male; Parkinson Disease; Wernicke Encephalopa | 2006 |
[The phenomenon of experimental motor retardation as one of the manifestations of the Parkinsonian syndrome].
Topics: Amphetamine; Animals; Catecholamines; Cats; Caudate Nucleus; Chlorpromazine; Dihydroergotoxine; Dise | 1975 |
Treatment of side-effects of levodopa.
Topics: Dihydroxyphenylalanine; Disulfiram; Humans; Hyperkinesis; Hypertension; Parkinson Disease | 1973 |
Reversal of reserpine-induced bradykinesia by alpha-methyldopa--new light on its modus operandi.
Topics: Animals; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Dose | 1974 |
Adjuvants to L-dopa for Parkinsonism.
Topics: Animals; Cats; Dihydroxyphenylalanine; Disulfiram; Drug Synergism; Humans; Isoniazid; Parkinson Dise | 1970 |