disulfiram has been researched along with Innate Inflammatory Response in 15 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "Overall, disulfiram reduced the host immune response in fungal keratitis by attenuating neutrophil and macrophage recruitment and inhibiting IL-1β secretion in macrophages." | 8.12 | Disulfiram inhibits IL-1β secretion and inflammatory cells recruitment in Aspergillus fumigatus keratitis. ( Che, C; Chen, X; Cong, P; Han, L; Lu, D; Sun, X; Wang, L; Yan, H; Yang, H, 2022) |
| "Oxidative stress, cell pyroptosis and inflammation are considered as important pathogenic factors for ulcerative colitis (UC) development, and the traditional anti-alcoholism drug disulfiram (DSF) has recently been reported to exert its regulating effects on all the above cellular functions, which makes DSF as ideal therapeutic agent for UC treatment, but this issue has not been fully studied." | 8.12 | The anti-alcoholism drug disulfiram effectively ameliorates ulcerative colitis through suppressing oxidative stresses-associated pyroptotic cell death and cellular inflammation in colonic cells. ( Chi, F; Du, F; Li, R; Lin, Z; Ren, N; Shi, X; Zhang, C; Zhang, G; Zhang, J; Zheng, X; Zhu, Y, 2022) |
| "Severe acute pancreatitis (SAP) is characterized by pancreatic and systemic inflammation and persistent organ failure." | 5.91 | Disulfiram relieves severe acute pancreatitis by inhibiting GSDMD-dependent NETs formation. ( Ding, Z; Han, CQ; Ling, X; Nie, C; Sheng, LP, 2023) |
| " We found that N-terminal GSDMD (N-GSDMD) was aberrantly expressed in epidermis of skin lesion in psoriasis patients and imiquimod-induced psoriasis-like dermatitis (IIPLD) mice." | 4.31 | Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis. ( Chen, H; Chen, Q; Chen, S; Chen, X; Chen, Y; Gu, H; Li, M; Lian, N; Yang, Y; Zhang, Y, 2023) |
| "Overall, disulfiram reduced the host immune response in fungal keratitis by attenuating neutrophil and macrophage recruitment and inhibiting IL-1β secretion in macrophages." | 4.12 | Disulfiram inhibits IL-1β secretion and inflammatory cells recruitment in Aspergillus fumigatus keratitis. ( Che, C; Chen, X; Cong, P; Han, L; Lu, D; Sun, X; Wang, L; Yan, H; Yang, H, 2022) |
| "Oxidative stress, cell pyroptosis and inflammation are considered as important pathogenic factors for ulcerative colitis (UC) development, and the traditional anti-alcoholism drug disulfiram (DSF) has recently been reported to exert its regulating effects on all the above cellular functions, which makes DSF as ideal therapeutic agent for UC treatment, but this issue has not been fully studied." | 4.12 | The anti-alcoholism drug disulfiram effectively ameliorates ulcerative colitis through suppressing oxidative stresses-associated pyroptotic cell death and cellular inflammation in colonic cells. ( Chi, F; Du, F; Li, R; Lin, Z; Ren, N; Shi, X; Zhang, C; Zhang, G; Zhang, J; Zheng, X; Zhu, Y, 2022) |
| " Disulfiram and glycyrrhizic acid treatment led to enhanced cell proliferation and increased expressions of pyroptosis-related inflammatory factors, while disulfiram showed better alleviative effects on the inflammation in chondrocytes in OA." | 4.02 | Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes. ( Lan, T; Li, C; Li, L, 2021) |
| "Severe acute pancreatitis (SAP) is characterized by pancreatic and systemic inflammation and persistent organ failure." | 1.91 | Disulfiram relieves severe acute pancreatitis by inhibiting GSDMD-dependent NETs formation. ( Ding, Z; Han, CQ; Ling, X; Nie, C; Sheng, LP, 2023) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 10 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Saunders, MJ | 1 |
| Edwards, BS | 1 |
| Zhu, J | 1 |
| Sklar, LA | 1 |
| Graves, SW | 1 |
| Yan, H | 1 |
| Yang, H | 1 |
| Wang, L | 1 |
| Sun, X | 1 |
| Han, L | 1 |
| Cong, P | 1 |
| Chen, X | 2 |
| Lu, D | 1 |
| Che, C | 1 |
| Tan, C | 1 |
| Reilly, B | 1 |
| Jha, A | 1 |
| Murao, A | 1 |
| Lee, Y | 1 |
| Brenner, M | 1 |
| Aziz, M | 1 |
| Wang, P | 1 |
| Chi, F | 1 |
| Zhang, G | 1 |
| Ren, N | 1 |
| Zhang, J | 1 |
| Du, F | 1 |
| Zheng, X | 1 |
| Zhang, C | 1 |
| Lin, Z | 1 |
| Li, R | 1 |
| Shi, X | 1 |
| Zhu, Y | 1 |
| Liu, C | 1 |
| Tang, J | 1 |
| Liu, S | 1 |
| Shen, C | 1 |
| Zhou, X | 1 |
| Lu, J | 1 |
| Li, M | 2 |
| Zhu, L | 1 |
| Zhou, W | 1 |
| Zhang, H | 1 |
| Huang, L | 1 |
| Sun, C | 1 |
| Yue, Y | 1 |
| Cao, X | 1 |
| Jia, H | 1 |
| Wang, C | 1 |
| Gao, Y | 1 |
| Ling, X | 1 |
| Nie, C | 1 |
| Sheng, LP | 1 |
| Han, CQ | 1 |
| Ding, Z | 1 |
| Lian, N | 1 |
| Chen, Y | 1 |
| Chen, S | 1 |
| Zhang, Y | 1 |
| Chen, H | 1 |
| Yang, Y | 1 |
| Gu, H | 1 |
| Chen, Q | 1 |
| Deng, W | 1 |
| Yang, Z | 1 |
| Yue, H | 1 |
| Ou, Y | 1 |
| Hu, W | 1 |
| Sun, P | 1 |
| Schmidt, FI | 1 |
| Latz, E | 1 |
| Li, C | 1 |
| Li, L | 1 |
| Lan, T | 1 |
| Spivak, AM | 1 |
| Planelles, V | 1 |
| Hassan, I | 1 |
| Ebaid, H | 1 |
| Alhazza, IM | 1 |
| Al-Tamimi, J | 1 |
| Aman, S | 1 |
| Abdel-Mageed, AM | 1 |
| Foley, K | 1 |
| Kast, RE | 1 |
| Altschuler, EL | 1 |
| Marikovsky, M | 1 |
| Ziv, V | 1 |
| Nevo, N | 1 |
| Harris-Cerruti, C | 1 |
| Mahler, O | 1 |
2 reviews available for disulfiram and Innate Inflammatory Response
| Article | Year |
|---|---|
Novel Latency Reversal Agents for HIV-1 Cure.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Adjuvants, Immunologic; Disulfiram; Histone Deacetylase Inhib | 2018 |
Ritonavir and disulfiram have potential to inhibit caspase-1 mediated inflammation and reduce neurological sequelae after minor blast exposure.
Topics: Caspase 1; Craniocerebral Trauma; Disulfiram; Humans; Inflammation; Ritonavir | 2009 |
13 other studies available for disulfiram and Innate Inflammatory Response
| Article | Year |
|---|---|
Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
Topics: Animals; Biotinylation; Flow Cytometry; Fluorescence Resonance Energy Transfer; Green Fluorescent Pr | 2010 |
Disulfiram inhibits IL-1β secretion and inflammatory cells recruitment in Aspergillus fumigatus keratitis.
Topics: Animals; Antifungal Agents; Aspergillosis; Aspergillus fumigatus; Disulfiram; Female; Fluorescent An | 2022 |
Active Release of eCIRP via Gasdermin D Channels to Induce Inflammation in Sepsis.
Topics: Animals; Disulfiram; Inflammation; Intracellular Signaling Peptides and Proteins; Lipopolysaccharide | 2022 |
The anti-alcoholism drug disulfiram effectively ameliorates ulcerative colitis through suppressing oxidative stresses-associated pyroptotic cell death and cellular inflammation in colonic cells.
Topics: Animals; Caco-2 Cells; Colitis, Ulcerative; Dextran Sulfate; Disulfiram; Glycogen Synthase Kinase 3 | 2022 |
Cathepsin B/NLRP3/GSDMD axis-mediated macrophage pyroptosis induces inflammation and fibrosis in systemic sclerosis.
Topics: Animals; Caspase 1; Cathepsin B; Disease Models, Animal; Disulfiram; Fibrosis; Humans; Inflammasomes | 2022 |
Disulfiram with Cu
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Mod | 2023 |
Disulfiram relieves severe acute pancreatitis by inhibiting GSDMD-dependent NETs formation.
Topics: Acute Disease; Animals; Disulfiram; Extracellular Traps; Inflammation; Mice; Pancreatitis | 2023 |
Gasdermin D-mediated keratinocyte pyroptosis as a key step in psoriasis pathogenesis.
Topics: Animals; Dermatitis; Disulfiram; Gasdermins; Imiquimod; Inflammation; Keratinocytes; Ki-67 Antigen; | 2023 |
Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation.
Topics: Disulfiram; Gout; Humans; Inflammasomes; Inflammation; NLR Family, Pyrin Domain-Containing 3 Protein | 2020 |
Jack of all trades inhibits inflammation (in sober people).
Topics: Disulfiram; Humans; Inflammation; Pyroptosis | 2020 |
Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes.
Topics: Cell Proliferation; Cells, Cultured; Chondrocytes; Disulfiram; Dose-Response Relationship, Drug; Gly | 2021 |
Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chelating Agents; Copper; Cytokines; Disu | 2019 |
Cu/Zn superoxide dismutase plays important role in immune response.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Exp | 2003 |