disulfiram has been researched along with Glioma in 5 studies
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Disulfiram (DSF) is an old alcohol-aversion drug that has anti-tumor activities against diverse cancer types such as GBM in preclinical studies, especially when it is combined with cupper ion (Cu)." | 5.62 | Therapeutic effect of disulfiram inclusion complex embedded in hydroxypropyl-β-cyclodextrin on intracranial glioma-bearing male rats via intranasal route. ( Li, C; Ma, D; Ma, L; Ma, W; Qu, Y; Sun, X; Xu, Z; Zhao, Z; Zhou, Y, 2021) |
| "Disulfiram is a drug used to support the treatment of chronic alcoholism and was found to be effective against diverse cancer types in preclinical studies." | 5.62 | Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation. ( Anderson, J; Cantilena, S; de Boer, J; Hargrave, D; Meier, S; Michod, D; Niklison Chirou, MV; Salomoni, P, 2021) |
| "Glioma is the most common of all central nervous system (CNS) malignancies and is associated with a poor prognosis." | 1.72 | Bulk and Single-Cell Transcriptome Analyses Revealed That the Pyroptosis of Glioma-Associated Macrophages Participates in Tumor Progression and Immunosuppression. ( Hua, Z; Li, C; Li, L; Wu, L; Yin, X, 2022) |
| "Disulfiram (DSF) is an old alcohol-aversion drug that has anti-tumor activities against diverse cancer types such as GBM in preclinical studies, especially when it is combined with cupper ion (Cu)." | 1.62 | Therapeutic effect of disulfiram inclusion complex embedded in hydroxypropyl-β-cyclodextrin on intracranial glioma-bearing male rats via intranasal route. ( Li, C; Ma, D; Ma, L; Ma, W; Qu, Y; Sun, X; Xu, Z; Zhao, Z; Zhou, Y, 2021) |
| "Disulfiram is a drug used to support the treatment of chronic alcoholism and was found to be effective against diverse cancer types in preclinical studies." | 1.62 | Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation. ( Anderson, J; Cantilena, S; de Boer, J; Hargrave, D; Meier, S; Michod, D; Niklison Chirou, MV; Salomoni, P, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 3 (60.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, L | 1 |
| Wu, L | 1 |
| Yin, X | 1 |
| Li, C | 2 |
| Hua, Z | 1 |
| Qu, Y | 1 |
| Sun, X | 1 |
| Ma, L | 1 |
| Xu, Z | 1 |
| Ma, W | 1 |
| Zhou, Y | 1 |
| Zhao, Z | 1 |
| Ma, D | 1 |
| Meier, S | 1 |
| Cantilena, S | 1 |
| Niklison Chirou, MV | 1 |
| Anderson, J | 1 |
| Hargrave, D | 1 |
| Salomoni, P | 1 |
| de Boer, J | 1 |
| Michod, D | 1 |
| Li, Y | 1 |
| Fu, SY | 1 |
| Wang, LH | 1 |
| Wang, FY | 1 |
| Wang, NN | 1 |
| Cao, Q | 1 |
| Wang, YT | 1 |
| Yang, JY | 1 |
| Wu, CF | 1 |
| Marikovsky, M | 1 |
| Nevo, N | 1 |
| Vadai, E | 1 |
| Harris-Cerruti, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized Phase 2 Trial of Treatment of Advanced Non Small Cell Lung Carcinoma With/Without Disulfiram and Cisplatin Navelbine[NCT00312819] | Phase 2/Phase 3 | 60 participants (Anticipated) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for disulfiram and Glioma
| Article | Year |
|---|---|
Bulk and Single-Cell Transcriptome Analyses Revealed That the Pyroptosis of Glioma-Associated Macrophages Participates in Tumor Progression and Immunosuppression.
Topics: Disulfiram; Gene Expression Profiling; Glioma; Humans; Immunosuppression Therapy; Lipopolysaccharide | 2022 |
Therapeutic effect of disulfiram inclusion complex embedded in hydroxypropyl-β-cyclodextrin on intracranial glioma-bearing male rats via intranasal route.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Intranasal; Animals; Disulfiram; Glioma; Male; Ra | 2021 |
Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation.
Topics: Alcoholism; Auranofin; Cell Line, Tumor; Cell Proliferation; Child; Disulfiram; Down-Regulation; Dru | 2021 |
Copper improves the anti-angiogenic activity of disulfiram through the EGFR/Src/VEGF pathway in gliomas.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; | 2015 |
Cu/Zn superoxide dismutase plays a role in angiogenesis.
Topics: Animals; Apoptosis; Brain Neoplasms; Carcinoma, Lewis Lung; Disulfiram; Endothelium, Vascular; Enzym | 2002 |