disulfiram has been researched along with Disease Models, Animal in 62 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (19.35) | 18.7374 |
| 1990's | 6 (9.68) | 18.2507 |
| 2000's | 8 (12.90) | 29.6817 |
| 2010's | 22 (35.48) | 24.3611 |
| 2020's | 14 (22.58) | 2.80 |
| Authors | Studies |
|---|---|
| Braisted, J; Dranchak, P; Earnest, TW; Gu, X; Hoon, MA; Inglese, J; Oliphant, E; Solinski, HJ | 1 |
| Abrams, RPM; Bachani, M; Balasubramanian, A; Brimacombe, K; Dorjsuren, D; Eastman, RT; Hall, MD; Jadhav, A; Lee, MH; Li, W; Malik, N; Nath, A; Padmanabhan, R; Simeonov, A; Steiner, JP; Teramoto, T; Yasgar, A; Zakharov, AV | 1 |
| Chen, H; Hao, Y; Hu, W; Hua, L; Liang, S; Ou, Y; Sun, P; Wu, D; Wu, X; Yang, Z; Yue, H; Zhang, C | 1 |
| Fang, YF; Huang, YZ; Ou, AT; Tang, XP; Wang, R; Zhang, JX; Zhang, M; Zhao, PF; Zhao, YG | 1 |
| Huang, J; Li, W; Liu, J; Peng, Z; Wei, S; Xiao, Z; Yang, Y; Zhang, B | 1 |
| Adrover, JM; Bram, Y; Carrau, L; Chandar, V; Daßler-Plenker, J; Egeblad, M; Houghton, S; Lyons, SK; Merrill, JR; Redmond, D; Schwartz, RE; Shevik, M; tenOever, BR | 1 |
| Boch, K; Brinckmann, J; Busch, H; Chakievska, L; Diel, L; Fähnrich, A; Künzel, S; Patzelt, S; Pigors, M; Schmidt, E; Steenbock, H | 1 |
| Li, M; Liu, C; Liu, S; Lu, J; Shen, C; Tang, J; Zhou, X; Zhu, L | 1 |
| Arima, T; Ikebukuro, T; Kasamatsu, M; Nakano, Y; Shimizu, A; Takahashi, H; Terashima, Y; Tobita, Y; Toda, E; Uchiyama, M | 1 |
| Cao, X; Gao, Y; Huang, L; Jia, H; Sun, C; Wang, C; Yue, Y; Zhang, H; Zhou, W | 1 |
| Ge, Y; Guo, J; Ikezoe, T; Li, Z; Qin, M; Shi, J; Shoji, T; Wang, Y; Xu, B | 1 |
| Kamoun, PP | 1 |
| Deguchi, S; Kanai, K; Kawasaki, N; Minami, M; Nagai, N; Ogata, F; Otake, H; Yamaguchi, M | 1 |
| Hou, X; Liu, X; Tian, J; Wang, B; Xiang, L; Xie, B; Zhou, D | 1 |
| Akdaş Reis, Y; Erkaya, S; Erten, Ö; Göktolga, Ü; Kiykaç Altinbaş, Ş; Şimşek, G; Tapisiz, OL | 1 |
| Han, X; Zhang, R; Zhang, Y | 1 |
| Bergman, J; de Moura, FB; Kohut, SJ | 1 |
| Hamazaki, T; Hoshina, T; Kodama, H; Kudo, S; Nakatani, Y; Nozaki, S; Shintaku, H; Watanabe, Y | 1 |
| Chopra, S; Das, S; Dasgupta, A; Garg, T | 1 |
| Chopra, S; Dasgupta, A; Kaul, G; Shukla, M; Thakare, R | 1 |
| Ashrafian, H; Bøtker, HE; Contractor, H; Cunnington, C; Diesch, J; Jensen, R; Kharbanda, RK; Manlhiot, C; Ormerod, JO; Redington, A; Schmidt, MR; Støttrup, NB | 1 |
| Ito, Y; Nagai, N | 2 |
| Chang, J; Han, J; Hua, Y; Liu, L; Shi, W; Yue, X | 1 |
| Brandt-Rauf, P; Cassai, N; Dinnen, RD; Fine, RL; Mao, Y; Nichols, G; Qiu, W; Slavkovich, VN; Su, GH | 1 |
| Fujisawa, C; Hamazaki, T; Hayashinaka, E; Hiroki, T; Kodama, H; Kudo, S; Ninomiya, E; Nomura, S; Nozaki, S; Shintaku, H; Takeda, T; Wada, Y; Watanabe, Y | 1 |
| Ito, Y; Mano, Y; Nagai, N; Okamoto, N; Shimomura, Y; Yoshioka, C | 1 |
| Ito, Y; Mano, Y; Nagai, N; Okamoto, N; Shimomura, Y; Tnabe, W; Yoshioka, C | 1 |
| Aman, A; Cairncross, JG; Dang, NH; Datti, A; Easaw, JC; Grinshtein, N; Hao, X; Kaplan, DR; King, JC; Luchman, A; Lun, X; Robbins, SM; Senger, DL; Uehling, D; Wang, X; Weiss, S; Wells, JC; Wrana, JL | 1 |
| Braun, JA; Chapman, A; Fernandez Del Ama, L; Hurlstone, AF; Jones, M; Mohr, J; Walker, P | 1 |
| Bi, X; Cao, L; Fang, X; Guan, Y; He, C; Huang, A; Liu, M; Pu, Y; Sang, D; Sun, D; Wang, D; Wang, Z; Zhao, M | 1 |
| Acet, M; Baykus, Y; Celik, N; Celik, O; Deniz, R; Ersahin, A; Ozerol, E; Ozerol, I | 1 |
| Ito, Y; Murao, T; Nagai, N; Okamoto, N | 1 |
| Olive, MF | 1 |
| Dou, L; He, J; Pan, X; Pang, Q; Xu, W; Zeng, S; Zeng, Y | 1 |
| Chikazawa, S; Higuchi, S; Hori, Y; Hoshi, F; Ito, Y; Itoh, N; Kanai, K; Nagai, N | 1 |
| Ito, Y; Nagai, N; Takeuchi, N | 1 |
| Bhadhprasit, W; Fujisawa, C; Hiroki, T; Kodama, H; Ogawa, E | 1 |
| Bilsel, Y; Bugra, D; Bulut, T; Cevikbas, U; Turkoglu, U; Yamaner, S | 1 |
| Bond, GR; Goetz, RJ; Lindsell, CJ; Otten, EJ; Sztajnkrycer, MD | 1 |
| Ito, Y; Kitagawa, S; Nabekura, T; Tomohiro, M | 1 |
| Egli, M; Heilig, M | 1 |
| Roesner, S; Soyka, M | 1 |
| Liles, LC; Schank, JR; Weinshenker, D | 1 |
| Carlson, GP; Fossa, AA | 1 |
| Wattenberg, LW | 1 |
| Fujioka, T; Fujiyama, K; Honda, S; Kubota, T; Murakami, K; Nasu, M; Shiota, K | 1 |
| Benjamin, D; Bhadra, S; Elkhayat, I; Harris, CM; Lal, H; Prather, PL | 1 |
| Cokneşelí, B; Köksoy, FN; Köse, H; Soybír, GR; Yalçin, O | 1 |
| Fetterer, RH; Hill, DE | 1 |
| Nash, T; Rice, WG | 1 |
| Holmdahl, R; Kalden, JR; Mikulowska, A; Voll, RE | 1 |
| Heros, RC; Negoro, M; Zervas, NT | 1 |
| Anzil, AP; Zuccarello, M | 1 |
| Fujieda, T; Miyagishi, T; Takahata, N; Ueno, T | 1 |
| Arushanian, EB | 1 |
| Sudilovsky, A | 1 |
| Kilmore, MA; Mahoney, AJ; Rymas, K; Sanny, CG | 1 |
| Phillips, SC | 1 |
| Ellinwood, EH; Grabowy, R; Sudilovsky, A | 1 |
| Calesnick, B; Irvin, JD; Mathews, GJ; Osterholm, JL | 1 |
| Duvoisin, RC; Marsden, CD | 1 |
5 review(s) available for disulfiram and Disease Models, Animal
| Article | Year |
|---|---|
Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Acute Lung Injury; Animals; COVID-19; Disease Models, Animal; Disulfiram; Extracellular Traps; Lung; Rodentia; SARS-CoV-2 | 2022 |
Pharmacological treatment of alcohol dependence: target symptoms and target mechanisms.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Baclofen; Corticotropin-Releasing Hormone; Disease Models, Animal; Disulfiram; Fructose; Humans; Naltrexone; Neuropeptide Y; Nociceptin; Ondansetron; Opioid Peptides; Receptor, Cannabinoid, CB1; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Taurine; Topiramate | 2006 |
New pharmacological approaches for the treatment of alcoholism.
Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Animals; Carbamazepine; Depression; Disease Models, Animal; Disulfiram; Fructose; Humans; Naltrexone; Secondary Prevention; Taurine; Topiramate | 2006 |
Inhibition of chemical carcinogenesis by antioxidants.
Topics: Animals; Antioxidants; Butylated Hydroxyanisole; Butylated Hydroxytoluene; Carcinogens; Cysteamine; Disease Models, Animal; Disulfiram; Ethoxyquin; Selenium | 1980 |
Cerebral vasospasm.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin II; Animals; Blood Platelets; Carbon Dioxide; Catecholamines; Chlorpromazine; Disease Models, Animal; Disulfiram; Humans; Ischemic Attack, Transient; Muscle Relaxants, Central; Nitroprusside; Phosphodiesterase Inhibitors; Prostaglandins; Serotonin; Serotonin Antagonists; Tyramine | 1976 |
1 trial(s) available for disulfiram and Disease Models, Animal
| Article | Year |
|---|---|
Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Analysis of Variance; Animals; Cross-Over Studies; Cyanamide; Disease Models, Animal; Disulfiram; Dose-Response Relationship, Drug; Double-Blind Method; Endothelium, Vascular; Enzyme Inhibitors; Forearm; Genotype; Hindlimb; Humans; Ischemic Preconditioning; Linear Models; Mutation; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Phenotype; Plethysmography; Rabbits; Regional Blood Flow; Reperfusion Injury; Time Factors; Vasodilation; Vasodilator Agents | 2013 |
56 other study(ies) available for disulfiram and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, Spinal; Humans; Mice, Inbred C57BL; Mice, Knockout; Neurons; Pruritus; Receptors, Atrial Natriuretic Factor; Reproducibility of Results; Signal Transduction; Small Molecule Libraries | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Drug Evaluation, Preclinical; High-Throughput Screening Assays; Immunocompetence; Inhibitory Concentration 50; Methacycline; Mice, Inbred C57BL; Protease Inhibitors; Quantitative Structure-Activity Relationship; Small Molecule Libraries; Vero Cells; Zika Virus; Zika Virus Infection | 2020 |
Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities.
Topics: Animals; Anti-Inflammatory Agents; Cell Line; Chalcones; Colitis; Disease Models, Animal; Drug Design; Female; Inflammasomes; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Reactive Oxygen Species; Sepsis; Structure-Activity Relationship | 2021 |
Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Animals; Anti-Inflammatory Agents; Biomimetic Materials; Colitis, Ulcerative; COVID-19; COVID-19 Drug Treatment; Disease Models, Animal; Disulfiram; Drug Carriers; Humans; Immunosuppressive Agents; Lactoferrin; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Nanoparticles; Pyroptosis; SARS-CoV-2; Systemic Inflammatory Response Syndrome; Treatment Outcome | 2021 |
Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice.
Topics: Acute Kidney Injury; Animals; Apoptosis; Blood Urea Nitrogen; Creatinine; Disease Models, Animal; Disulfiram; In Situ Nick-End Labeling; Inflammasomes; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress | 2022 |
Increased Fibrosis in a Mouse Model of Anti-Laminin 332 Mucous Membrane Pemphigoid Remains Unaltered by Inhibition of Aldehyde Dehydrogenase.
Topics: Aldehyde Dehydrogenase; Animals; Autoimmune Diseases; Cicatrix; Collagen; Disease Models, Animal; Disulfiram; Fibrosis; Immunoglobulin G; Mice; Mice, Inbred C57BL; Mucous Membrane; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous | 2021 |
Cathepsin B/NLRP3/GSDMD axis-mediated macrophage pyroptosis induces inflammation and fibrosis in systemic sclerosis.
Topics: Animals; Caspase 1; Cathepsin B; Disease Models, Animal; Disulfiram; Fibrosis; Humans; Inflammasomes; Inflammation; Lipopolysaccharides; Macrophages; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Pyroptosis; Scleroderma, Systemic; Silicon Dioxide | 2022 |
Disulfiram Ophthalmic Solution Inhibited Macrophage Infiltration by Suppressing Macrophage Pseudopodia Formation in a Rat Corneal Alkali Burn Model.
Topics: Alkalies; Animals; Burns, Chemical; Cornea; Corneal Injuries; Corneal Neovascularization; Disease Models, Animal; Disulfiram; Eye Burns; Macrophages; Ophthalmic Solutions; Pseudopodia; Rats | 2023 |
Disulfiram with Cu
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Disulfiram; Inflammation; Inflammatory Bowel Diseases; Interleukin-17; Mice; Mice, Inbred C57BL; NF-kappa B; RNA, Ribosomal, 16S | 2023 |
Pharmacological Inhibition of Gasdermin D Suppresses Angiotensin II-Induced Experimental Abdominal Aortic Aneurysms.
Topics: Angiotensin II; Animals; Aortic Aneurysm, Abdominal; Body Weight; Disease Models, Animal; Disulfiram; Gasdermins; Male; Mice; Mice, Inbred C57BL | 2023 |
Mental retardation in Down syndrome: Two ways to treat.
Topics: Aminooxyacetic Acid; Animals; Benserazide; Brain; Chromosomes, Human, Pair 21; Cobamides; Cystathionine beta-Synthase; Disease Models, Animal; Disease Progression; Disulfiram; Down Syndrome; Enzyme Inhibitors; Gene Dosage; Humans; Hydrogen Sulfide; Infant, Newborn; Intellectual Disability; Mice; Mitochondria; Rats; Sodium Nitrite; Species Specificity; Thiosulfates | 2019 |
In Situ Gel Incorporating Disulfiram Nanoparticles Rescues the Retinal Dysfunction via ATP Collapse in Otsuka Long-Evans Tokushima Fatty Rats.
Topics: Adenosine Triphosphate; Animals; Diabetic Retinopathy; Disease Models, Animal; Disulfiram; Gels; Humans; Nanoparticles; Rats; Rats, Inbred OLETF; Retina; Retinal Diseases | 2020 |
Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice.
Topics: Animals; Arthritis, Gouty; Creatinine; Cytokines; Disease Models, Animal; Disulfiram; Humans; Mice; Oxonic Acid; Pyroptosis; Uric Acid | 2022 |
The Effect of Disulfiram in the Prevention of Postoperative Adhesion Formation in an Experimental Rat Uterine Horn Model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Disulfiram; Drug Administration Schedule; Electrocoagulation; Female; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats, Wistar; Time Factors; Tissue Adhesions; Uterine Diseases; Uterus; Vascular Endothelial Growth Factor A | 2021 |
Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Survival; Disease Models, Animal; Disulfiram; Fibrosis; Humans; Intracellular Signaling Peptides and Proteins; Kidney; Male; Phosphate-Binding Proteins; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; Ureteral Obstruction | 2021 |
Limited modulation of the abuse-related behavioral effects of d-methamphetamine by disulfiram.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Amphetamine-Related Disorders; Animals; Behavioral Symptoms; Central Nervous System Stimulants; Cocaine; Discrimination, Psychological; Disease Models, Animal; Disulfiram; Dose-Response Relationship, Drug; Female; Macaca mulatta; Male; Methamphetamine; Reinforcement, Psychology; Treatment Outcome | 2018 |
Disulfiram enhanced delivery of orally administered copper into the central nervous system in Menkes disease mouse model.
Topics: Animals; Autoradiography; Blood-Brain Barrier; Copper; Disease Models, Animal; Disulfiram; Drug Carriers; Male; Menkes Kinky Hair Syndrome; Mice; Mice, Inbred C3H | 2018 |
Repurposing disulfiram to target infections caused by non-tuberculous mycobacteria.
Topics: Animals; Anti-Bacterial Agents; Chlorocebus aethiops; Colony Count, Microbial; Disease Models, Animal; Disulfiram; Drug Repositioning; Macrophages; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Mycobacterium abscessus; Mycobacterium fortuitum; Mycobacterium Infections, Nontuberculous; Neutropenia; Nontuberculous Mycobacteria; Vero Cells | 2019 |
Repurposing disulfiram for treatment of Staphylococcus aureus infections.
Topics: Alcohol Deterrents; Animals; Anti-Bacterial Agents; Chlorocebus aethiops; Disease Models, Animal; Disulfiram; Drug Evaluation, Preclinical; Mice, Inbred BALB C; Microbial Sensitivity Tests; Staphylococcal Infections; Staphylococcus aureus; Therapeutic Index, Drug; Treatment Outcome; Vero Cells | 2019 |
Excessive hydrogen peroxide enhances the attachment of amyloid β1-42 in the lens epithelium of UPL rats, a hereditary model for cataracts.
Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Brain; Cataract; Disease Models, Animal; Disulfiram; Epithelium; Free Radical Scavengers; Hydrogen Peroxide; Lens, Crystalline; Peptide Fragments; Rats; Rats, Sprague-Dawley; Retina; RNA, Messenger | 2014 |
A binuclear complex constituted by diethyldithiocarbamate and copper(I) functions as a proteasome activity inhibitor in pancreatic cancer cultures and xenografts.
Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Copper; Disease Models, Animal; Disulfiram; Ditiocarb; Female; Humans; In Situ Nick-End Labeling; Mice; Mice, Nude; NF-kappa B; Pancreatic Neoplasms; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Xenograft Model Antitumor Assays | 2013 |
Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Ascorbic Acid; Cell Line, Tumor; Disease Models, Animal; Disulfiram; Dose-Response Relationship, Drug; Heterografts; Humans; Male; Mice; Necrosis; Oxides; Pancreatic Neoplasms; Reactive Oxygen Species; Tumor Stem Cell Assay; Voltage-Dependent Anion Channels | 2013 |
PET imaging analysis with 64Cu in disulfiram treatment for aberrant copper biodistribution in Menkes disease mouse model.
Topics: Animals; Autoradiography; Brain; Chelating Agents; Copper; Copper Radioisotopes; Disease Models, Animal; Disulfiram; Gamma Rays; Kidney; Liver; Menkes Kinky Hair Syndrome; Mice; Mice, Inbred C3H; Mutation; Penicillamine; Positron-Emission Tomography; Radiopharmaceuticals; Time Factors; Tissue Distribution; Whole Body Imaging | 2014 |
Effect of Eye Drops Containing Disulfiram and Low-Substituted Methylcellulose in Reducing Intraocular Pressure in Rabbit Models.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Topical; Alcohol Deterrents; Animals; Aqueous Humor; beta-Cyclodextrins; Disease Models, Animal; Disulfiram; Drug Combinations; Drug Delivery Systems; Hypromellose Derivatives; Intraocular Pressure; Male; Methylcellulose; Nitric Oxide; Ophthalmic Solutions; Rabbits; Tonometry, Ocular | 2015 |
A nanoparticle formulation of disulfiram prolongs corneal residence time of the drug and reduces intraocular pressure.
Topics: Animals; Cornea; Disease Models, Animal; Disulfiram; Drug Delivery Systems; Escherichia coli; Free Radical Scavengers; Humans; Intraocular Pressure; Male; Nanoparticles; Ocular Hypertension; Ophthalmic Solutions; Rabbits; Tonometry, Ocular; Wound Healing | 2015 |
Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cell Survival; Copper; Dacarbazine; Disease Models, Animal; Disulfiram; DNA Repair; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Female; Gene Expression Profiling; Glioblastoma; High-Throughput Screening Assays; Humans; Mice; Neoplastic Stem Cells; Proteasome Endopeptidase Complex; Temozolomide; Tumor Burden; Xenograft Model Antitumor Assays | 2016 |
Reprofiling using a zebrafish melanoma model reveals drugs cooperating with targeted therapeutics.
Topics: Abietanes; Animals; Animals, Genetically Modified; Apoptosis; Benzamides; Cell Line, Tumor; Disease Models, Animal; Disulfiram; Drug Repositioning; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Humans; MAP Kinase Kinase Kinases; Melanins; Melanocytes; Melanoma; Oligonucleotides, Antisense; Phenotype; Protein Kinase Inhibitors; Signal Transduction; Sirolimus; Skin Neoplasms; Zebrafish | 2016 |
Disulfiram and Diphenhydramine Hydrochloride Upregulate miR-30a to Suppress IL-17-Associated Autoimmune Inflammation.
Topics: Animals; Case-Control Studies; Cell Differentiation; Cells, Cultured; Diphenhydramine; Disease Models, Animal; Disulfiram; Encephalomyelitis, Autoimmune, Experimental; Female; HEK293 Cells; Humans; Interferon Regulatory Factors; Interleukin-17; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Myelin Proteolipid Protein; Myelin-Oligodendrocyte Glycoprotein; Peptide Fragments; Statistics, Nonparametric; Transfection; Up-Regulation | 2016 |
Disulfiram, as a candidate NF-κB and proteasome inhibitor, prevents endometriotic implant growing in a rat model of endometriosis.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Animals; Disease Models, Animal; Disulfiram; Endometriosis; Female; Humans; NF-kappa B; Proteasome Inhibitors; Rats; Tumor Necrosis Factor-alpha | 2016 |
Disulfiram reduces elevated blood glucose levels in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of type 2 diabetes.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Disulfiram; Feeding Behavior; Rats; Rats, Inbred OLETF | 2009 |
Pharmacotherapies for alcoholism: the old and the new.
Topics: Acamprosate; Alcohol Deterrents; Alcohol-Induced Disorders, Nervous System; Alcoholism; Animals; Disease Models, Animal; Disulfiram; Drug Design; Humans; Naltrexone; Narcotic Antagonists; Neuropeptides; Neuropharmacology; Neurotransmitter Agents; Receptors, Neurotransmitter; Taurine | 2010 |
Methylene chloride protects against cecal ligation and puncture-induced acute lung injury by modulating inflammatory mediators.
Topics: Acute Lung Injury; Animals; Carbon Monoxide; Cecum; Cytoprotection; Disease Models, Animal; Disulfiram; Humans; Immunomodulation; Inflammation Mediators; Methylene Chloride; Peroxidase; Pneumonia; Rats; Rats, Sprague-Dawley; Sepsis; Tumor Necrosis Factor-alpha | 2010 |
Effects of instillation of eyedrops containing disulfiram and hydroxypropyl-β-cyclodextrin inclusion complex on endotoxin-induced uveitis in rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; Anti-Inflammatory Agents; Aqueous Humor; beta-Cyclodextrins; Dexamethasone; Dinoprostone; Disease Models, Animal; Disulfiram; Dose-Response Relationship, Drug; Lipopolysaccharides; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Ophthalmic Solutions; Rats; Rats, Inbred Lew; Tumor Necrosis Factor-alpha; Uveitis | 2012 |
Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model.
Topics: Animals; Antioxidants; Cataract; Disease Models, Animal; Disulfiram; Drug Carriers; Hypromellose Derivatives; Male; Methylcellulose; Ophthalmic Solutions; Rabbits; Rats | 2012 |
Effect of copper and disulfiram combination therapy on the macular mouse, a model of Menkes disease.
Topics: Animals; Blood-Brain Barrier; Copper; Disease Models, Animal; Disulfiram; Electron Transport Complex IV; Male; Menkes Kinky Hair Syndrome; Mice | 2012 |
Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Disulfiram; Enzyme Inhibitors; Honey; Male; Nitric Oxide; Peroxidase; Prednisolone; Rats; Rats, Wistar; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid | 2002 |
Mitigation of pennyroyal oil hepatotoxicity in the mouse.
Topics: Animals; Case-Control Studies; Cimetidine; Cyclohexane Monoterpenes; Cyclohexanones; Disease Models, Animal; Disulfiram; Enzyme Inhibitors; Female; Hedeoma; Liver Diseases; Mentha pulegium; Mice; Mice, Inbred BALB C; Monoterpenes; Oils, Volatile | 2003 |
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
Topics: Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cataract; Cell Membrane; Disease Models, Animal; Disulfiram; Enzyme Inhibitors; Guanidines; Lens, Crystalline; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2004 |
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Cataract; Disease Models, Animal; Disulfiram; Down-Regulation; Electron Transport Complex IV; Enzyme Inhibitors; Eye Diseases, Hereditary; Gene Expression Regulation, Enzymologic; Guanidines; Lens, Crystalline; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Up-Regulation | 2007 |
Norepinephrine signaling through beta-adrenergic receptors is critical for expression of cocaine-induced anxiety.
Topics: Adrenergic beta-Antagonists; Animals; Anxiety; Behavior, Animal; Cocaine; Disease Models, Animal; Disulfiram; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Male; Maze Learning; Mice; Mice, Knockout; Norepinephrine; Propranolol; Receptors, Adrenergic, beta; Signal Transduction | 2008 |
Antiarrhythmic effect of disulfiram in various cardiotoxic models.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Disulfiram; Heart Diseases; Male; Myocardial Contraction; Ouabain; Quinidine; Rabbits; Rats; Rats, Inbred Strains | 1983 |
Effects of ethanol on the pancreas of disulfiram-treated rats.
Topics: Acetaldehyde; Acute Disease; Administration, Oral; Amylases; Animals; Disease Models, Animal; Disulfiram; Ethanol; Male; Microscopy, Electron; Organ Size; Pancreatitis; Random Allocation; Rats; Rats, Wistar | 1995 |
Anxiogenic effect of disulfiram evaluated in an animal model.
Topics: Acetaldehyde; Animals; Appetitive Behavior; Arousal; Conditioning, Operant; Discrimination Learning; Disease Models, Animal; Disulfiram; Ditiocarb; Dose-Response Relationship, Drug; Ethanol; Fear; Injections, Intraperitoneal; Male; Pargyline; Pentylenetetrazole; Rats | 1993 |
The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis.
Topics: Acetic Acid; Animals; Calcium Channel Blockers; Catalase; Colitis; Colonic Diseases; Deferoxamine; Disease Models, Animal; Disulfiram; Free Radical Scavengers; Gastrointestinal Agents; Male; Rats; Rats, Inbred Strains; Rats, Wistar; Reactive Oxygen Species; Siderophores; Superoxide Dismutase; Ulcer; Verapamil | 1997 |
The effect of disulfiram on egg shell formation in adult Trichuris muris.
Topics: Administration, Oral; Animals; Disease Models, Animal; Disulfiram; Dose-Response Relationship, Drug; Enzyme Inhibitors; Feces; Female; Immunohistochemistry; Mice; Mice, Inbred AKR; Monophenol Monooxygenase; Oviposition; Ovum; Parasite Egg Count; Trichuriasis; Trichuris | 1997 |
Efficacies of zinc-finger-active drugs against Giardia lamblia.
Topics: Animals; Antiprotozoal Agents; Disease Models, Animal; Disulfiram; Drug Evaluation, Preclinical; Giardia lamblia; Giardiasis; Mice; Zinc Fingers | 1998 |
Amelioration of type II collagen induced arthritis in rats by treatment with sodium diethyldithiocarbamate.
Topics: Animals; Arthritis, Rheumatoid; Collagen; Disease Models, Animal; Disulfiram; Ditiocarb; Drug Administration Routes; Female; Infusion Pumps, Implantable; NF-kappa B; Prodrugs; Rats; Severity of Illness Index; Tarsus, Animal; Time Factors | 1999 |
A localized model of experimental neuropathy by topical application of disulfiram.
Topics: Animals; Disease Models, Animal; Disulfiram; Male; Peripheral Nervous System Diseases; Rats; Sciatic Nerve | 1979 |
Electron microscopic studies on the cerebral lesions of rats in experimental chronic disulfiram poisoning.
Topics: Animals; Brain; Capillaries; Cerebral Cortex; Chronic Disease; Disease Models, Animal; Disulfiram; Hypothalamus; Male; Microscopy, Electron; Neuroglia; Neurons; Rats | 1977 |
[The phenomenon of experimental motor retardation as one of the manifestations of the Parkinsonian syndrome].
Topics: Amphetamine; Animals; Catecholamines; Cats; Caudate Nucleus; Chlorpromazine; Dihydroergotoxine; Disease Models, Animal; Disulfiram; Electric Stimulation; Methyltyrosines; Motor Activity; Muscles; Parkinson Disease; Propranolol | 1975 |
Effects of disulfiram on the amphetamine-induced behavioral syndrome in the cat as a model of psychosis.
Topics: Animals; Behavior, Animal; Cats; Disease Models, Animal; Disulfiram; Drug Interactions; Female; Humans; Methamphetamine; Motor Activity; Psychotic Disorders; Stereotyped Behavior; Time Factors | 1975 |
Effect of disulfiram on canine liver aldehyde dehydrogenase activity: in vivo inactivation in a nonrodent animal model.
Topics: Aldehyde Dehydrogenase; Animals; Disease Models, Animal; Disulfiram; Dogs; Dose-Response Relationship, Drug; Female; Liver; Male; Microsomes, Liver; Mitochondria, Liver | 1988 |
Can brain lesions occur in experimental animals by administration of ethanol or acetaldehyde?
Topics: Acetaldehyde; Administration, Inhalation; Alcoholism; Animals; Brain; Disease Models, Animal; Disulfiram; Ethanol; Male; Nerve Degeneration; Rats; Rats, Inbred Strains; Volatilization | 1987 |
Olfactory forebrain seizures induced by methamphetamine and disulfiram.
Topics: Amphetamine; Animals; Brain; Brain Chemistry; Cats; Disease Models, Animal; Disulfiram; Dopamine; Electroencephalography; Epilepsy, Temporal Lobe; Female; Humans; Limbic System; Methamphetamine; Norepinephrine; Olfactory Bulb; Pattern Recognition, Automated; Psychoses, Substance-Induced; Seizures; Substantia Nigra | 1973 |
Chapter 29. Anti-norepinephrine therapy against traumatic hemorrhagic necrosis of the spinal cord: preliminary report.
Topics: Animals; Bretylium Compounds; Cats; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Guanethidine; Hemorrhage; Hydroxydopamines; Methyldopa; Necrosis; Norepinephrine; Phenoxybenzamine; Reserpine; Spinal Cord; Spinal Cord Injuries; Sympatholytics | 1973 |
Reversal of reserpine-induced bradykinesia by alpha-methyldopa--new light on its modus operandi.
Topics: Animals; Carbidopa; Chlorpromazine; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Dose-Response Relationship, Drug; Drug Synergism; Methyldopa; Mice; Movement Disorders; Parkinson Disease; Phenoxybenzamine; Pimozide; Reserpine | 1974 |