disulfiram has been researched along with Cataract in 15 studies
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We attempted to develop anti-cataract eye drops using disulfiram (DSF) and low-substituted methylcellulose (MC), and evaluated their anti-cataract effect in terms of the lens opacification vs." | 7.78 | Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model. ( Ito, Y; Nagai, N; Takeuchi, N, 2012) |
| "We found a new pharmacological effect of disulfiram (DSF) against rat pups with cataract induced by selenite injection." | 7.70 | Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats. ( Cai, H; Ito, Y; Koizumi, Y; Nakao, M; Terao, M, 1999) |
| "We previously demonstrated that topical treatment with disulfiram (DSF) prevented the development of cataracts in sodium selenite-injected rat pups." | 7.70 | Effects of lipid composition on the transcorneal penetration of liposomes containing disulfiram, a potential anti-cataract agent, in the rabbit. ( Cai, H; Hori, R; Ito, Y; Kimura, T; Koizumi, Y; Takagi, S; Terao, M; Tomohiro, M, 2000) |
| " This system increases both the drug solubility in aqueous eye drops and the permeability of drug into the rabbit eye, by the formation of a drug-cyclodextrin inclusion complex, and so enhances the ocular bioavailability and anti-cataract effect of DSF." | 5.32 | Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats. ( Ito, Y; Li, D; Nabekura, T; Wang, S; Wu, C; Zhang, J, 2004) |
| "We attempted to develop anti-cataract eye drops using disulfiram (DSF) and low-substituted methylcellulose (MC), and evaluated their anti-cataract effect in terms of the lens opacification vs." | 3.78 | Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model. ( Ito, Y; Nagai, N; Takeuchi, N, 2012) |
| "We found a new pharmacological effect of disulfiram (DSF) against rat pups with cataract induced by selenite injection." | 3.70 | Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats. ( Cai, H; Ito, Y; Koizumi, Y; Nakao, M; Terao, M, 1999) |
| "We previously demonstrated that topical treatment with disulfiram (DSF) prevented the development of cataracts in sodium selenite-injected rat pups." | 3.70 | Effects of lipid composition on the transcorneal penetration of liposomes containing disulfiram, a potential anti-cataract agent, in the rabbit. ( Cai, H; Hori, R; Ito, Y; Kimura, T; Koizumi, Y; Takagi, S; Terao, M; Tomohiro, M, 2000) |
| "Disulfiram, a dimer of diethyldithiocarbamate (DDC) which is a strong radical scavenger, is known to prevent cataract development." | 3.70 | Preparation and in vivo ocular absorption studies of disulfiram solid dispersion. ( Cai, H; Hori, R; Ito, Y; Nabekura, T; Terao, M, 2000) |
| " This system increases both the drug solubility in aqueous eye drops and the permeability of drug into the rabbit eye, by the formation of a drug-cyclodextrin inclusion complex, and so enhances the ocular bioavailability and anti-cataract effect of DSF." | 1.32 | Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats. ( Ito, Y; Li, D; Nabekura, T; Wang, S; Wu, C; Zhang, J, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fursova, AZ | 1 |
| Rumyantseva, YV | 1 |
| Kolosova, NG | 1 |
| Kedik, SA | 1 |
| Panov, AV | 1 |
| Tyukova, VC | 1 |
| Liu, C | 1 |
| Lan, Q | 1 |
| He, W | 1 |
| Nie, C | 1 |
| Zhang, C | 1 |
| Xu, T | 1 |
| Jiang, T | 1 |
| Wang, S | 3 |
| Nagai, N | 6 |
| Ito, Y | 12 |
| Sternberg, K | 1 |
| Terwee, T | 1 |
| Stachs, O | 1 |
| Guthoff, R | 1 |
| Löbler, M | 1 |
| Schmitz, KP | 1 |
| Takeuchi, N | 3 |
| Nabekura, T | 4 |
| Koizumi, Y | 3 |
| Nakao, M | 2 |
| Tomohiro, M | 3 |
| Inomata, M | 1 |
| Kitagawa, S | 1 |
| Li, D | 1 |
| Zhang, J | 1 |
| Wu, C | 1 |
| Takeda, M | 1 |
| Kamei, A | 1 |
| Jiang, TY | 1 |
| Wang, SL | 1 |
| Liu, Y | 1 |
| Nie, SF | 1 |
| Wu, CF | 1 |
| Cai, H | 3 |
| Terao, M | 3 |
| Hori, R | 2 |
| Kimura, T | 1 |
| Takagi, S | 1 |
15 other studies available for disulfiram and Cataract
| Article | Year |
|---|---|
[Disulfiram inhibites the development of cataract in OXYS rats].
Topics: Animals; Cataract; Disulfiram; Humans; Lens, Crystalline; Rats | 2016 |
Octa-arginine modified lipid emulsions as a potential ocular delivery system for disulfiram: A study of the corneal permeation, transcorneal mechanism and anti-cataract effect.
Topics: Animals; Cataract; Cornea; Coumarins; Disulfiram; Drug Delivery Systems; Emulsions; Fluorescent Dyes | 2017 |
Excessive hydrogen peroxide enhances the attachment of amyloid β1-42 in the lens epithelium of UPL rats, a hereditary model for cataracts.
Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secret | 2014 |
Drug-induced secondary cataract prevention: experimental ex vivo and in vivo results with disulfiram, methotrexate and actinomycin D.
Topics: Animals; Capsulorhexis; Cataract; Cell Count; Cell Culture Techniques; Cell Proliferation; Dactinomy | 2010 |
Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model.
Topics: Animals; Antioxidants; Cataract; Disease Models, Animal; Disulfiram; Drug Carriers; Hypromellose Der | 2012 |
Delay of cataract development in hereditary cataract UPL rats by disulfiram and aminoguanidine.
Topics: Aging; Animals; Antioxidants; Calcium; Cataract; Crystallins; Disulfiram; Enzyme Inhibitors; Eye Dis | 2003 |
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
Topics: Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cataract; Cell Membrane; Disease Mode | 2004 |
Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Topical; Animals; Aqueous Humor; beta-Cyclodextri | 2004 |
Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-beta-cyclodextrin inclusion complex.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Cataract; Cornea; Disulfiram; Ditioc | 2007 |
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
Topics: Adenosine Triphosphate; Administration, Oral; Animals; Cataract; Disease Models, Animal; Disulfiram; | 2007 |
In vitro cell culture model for anti-cataract drug penetration studies.
Topics: Aldehyde Dehydrogenase; Animals; Cataract; Cell Line; Cell Membrane Permeability; Collagen Type IV; | 2007 |
Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract ICR/f rats.
Topics: Alcohol Deterrents; Animals; Calcium; Calcium-Transporting ATPases; Cataract; Cyclodextrins; Disulfi | 2008 |
Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats.
Topics: Administration, Intranasal; Animals; Cataract; Disulfiram; Ditiocarb; Drug Carriers; Female; Liposom | 1999 |
Effects of lipid composition on the transcorneal penetration of liposomes containing disulfiram, a potential anti-cataract agent, in the rabbit.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Antioxidants; Calorimetry, Differential Scanning; Catar | 2000 |
Preparation and in vivo ocular absorption studies of disulfiram solid dispersion.
Topics: Absorption; Animals; Cataract; Dimerization; Disulfiram; Ditiocarb; Drug Carriers; Drug Compounding; | 2000 |