Page last updated: 2024-10-26

disulfiram and Cataract

disulfiram has been researched along with Cataract in 15 studies

Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)

Research Excerpts

ExcerptRelevanceReference
"We attempted to develop anti-cataract eye drops using disulfiram (DSF) and low-substituted methylcellulose (MC), and evaluated their anti-cataract effect in terms of the lens opacification vs."7.78Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model. ( Ito, Y; Nagai, N; Takeuchi, N, 2012)
"We found a new pharmacological effect of disulfiram (DSF) against rat pups with cataract induced by selenite injection."7.70Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats. ( Cai, H; Ito, Y; Koizumi, Y; Nakao, M; Terao, M, 1999)
"We previously demonstrated that topical treatment with disulfiram (DSF) prevented the development of cataracts in sodium selenite-injected rat pups."7.70Effects of lipid composition on the transcorneal penetration of liposomes containing disulfiram, a potential anti-cataract agent, in the rabbit. ( Cai, H; Hori, R; Ito, Y; Kimura, T; Koizumi, Y; Takagi, S; Terao, M; Tomohiro, M, 2000)
" This system increases both the drug solubility in aqueous eye drops and the permeability of drug into the rabbit eye, by the formation of a drug-cyclodextrin inclusion complex, and so enhances the ocular bioavailability and anti-cataract effect of DSF."5.32Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats. ( Ito, Y; Li, D; Nabekura, T; Wang, S; Wu, C; Zhang, J, 2004)
"We attempted to develop anti-cataract eye drops using disulfiram (DSF) and low-substituted methylcellulose (MC), and evaluated their anti-cataract effect in terms of the lens opacification vs."3.78Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model. ( Ito, Y; Nagai, N; Takeuchi, N, 2012)
"We found a new pharmacological effect of disulfiram (DSF) against rat pups with cataract induced by selenite injection."3.70Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats. ( Cai, H; Ito, Y; Koizumi, Y; Nakao, M; Terao, M, 1999)
"We previously demonstrated that topical treatment with disulfiram (DSF) prevented the development of cataracts in sodium selenite-injected rat pups."3.70Effects of lipid composition on the transcorneal penetration of liposomes containing disulfiram, a potential anti-cataract agent, in the rabbit. ( Cai, H; Hori, R; Ito, Y; Kimura, T; Koizumi, Y; Takagi, S; Terao, M; Tomohiro, M, 2000)
"Disulfiram, a dimer of diethyldithiocarbamate (DDC) which is a strong radical scavenger, is known to prevent cataract development."3.70Preparation and in vivo ocular absorption studies of disulfiram solid dispersion. ( Cai, H; Hori, R; Ito, Y; Nabekura, T; Terao, M, 2000)
" This system increases both the drug solubility in aqueous eye drops and the permeability of drug into the rabbit eye, by the formation of a drug-cyclodextrin inclusion complex, and so enhances the ocular bioavailability and anti-cataract effect of DSF."1.32Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats. ( Ito, Y; Li, D; Nabekura, T; Wang, S; Wu, C; Zhang, J, 2004)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (6.67)18.2507
2000's9 (60.00)29.6817
2010's5 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Fursova, AZ1
Rumyantseva, YV1
Kolosova, NG1
Kedik, SA1
Panov, AV1
Tyukova, VC1
Liu, C1
Lan, Q1
He, W1
Nie, C1
Zhang, C1
Xu, T1
Jiang, T1
Wang, S3
Nagai, N6
Ito, Y12
Sternberg, K1
Terwee, T1
Stachs, O1
Guthoff, R1
Löbler, M1
Schmitz, KP1
Takeuchi, N3
Nabekura, T4
Koizumi, Y3
Nakao, M2
Tomohiro, M3
Inomata, M1
Kitagawa, S1
Li, D1
Zhang, J1
Wu, C1
Takeda, M1
Kamei, A1
Jiang, TY1
Wang, SL1
Liu, Y1
Nie, SF1
Wu, CF1
Cai, H3
Terao, M3
Hori, R2
Kimura, T1
Takagi, S1

Other Studies

15 other studies available for disulfiram and Cataract

ArticleYear
[Disulfiram inhibites the development of cataract in OXYS rats].
    Advances in gerontology = Uspekhi gerontologii, 2016, Volume: 29, Issue:1

    Topics: Animals; Cataract; Disulfiram; Humans; Lens, Crystalline; Rats

2016
Octa-arginine modified lipid emulsions as a potential ocular delivery system for disulfiram: A study of the corneal permeation, transcorneal mechanism and anti-cataract effect.
    Colloids and surfaces. B, Biointerfaces, 2017, Dec-01, Volume: 160

    Topics: Animals; Cataract; Cornea; Coumarins; Disulfiram; Drug Delivery Systems; Emulsions; Fluorescent Dyes

2017
Excessive hydrogen peroxide enhances the attachment of amyloid β1-42 in the lens epithelium of UPL rats, a hereditary model for cataracts.
    Toxicology, 2014, Jan-06, Volume: 315

    Topics: Age Factors; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secret

2014
Drug-induced secondary cataract prevention: experimental ex vivo and in vivo results with disulfiram, methotrexate and actinomycin D.
    Ophthalmic research, 2010, Volume: 44, Issue:4

    Topics: Animals; Capsulorhexis; Cataract; Cell Count; Cell Culture Techniques; Cell Proliferation; Dactinomy

2010
Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model.
    Biological & pharmaceutical bulletin, 2012, Volume: 35, Issue:2

    Topics: Animals; Antioxidants; Cataract; Disease Models, Animal; Disulfiram; Drug Carriers; Hypromellose Der

2012
Delay of cataract development in hereditary cataract UPL rats by disulfiram and aminoguanidine.
    Experimental eye research, 2003, Volume: 76, Issue:2

    Topics: Aging; Animals; Antioxidants; Calcium; Cataract; Crystallins; Disulfiram; Enzyme Inhibitors; Eye Dis

2003
Changes in plasma membrane Ca2+ -ATPase expression and ATP content in lenses of hereditary cataract UPL rats.
    Toxicology, 2004, Apr-15, Volume: 197, Issue:2

    Topics: Adenosine Triphosphate; Animals; Calcium-Transporting ATPases; Cataract; Cell Membrane; Disease Mode

2004
Bioavailability and anticataract effects of a topical ocular drug delivery system containing disulfiram and hydroxypropyl-beta-cyclodextrin on selenite-treated rats.
    Current eye research, 2004, Volume: 29, Issue:1

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Administration, Topical; Animals; Aqueous Humor; beta-Cyclodextri

2004
Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-beta-cyclodextrin inclusion complex.
    Biological & pharmaceutical bulletin, 2007, Volume: 30, Issue:8

    Topics: 2-Hydroxypropyl-beta-cyclodextrin; Animals; beta-Cyclodextrins; Cataract; Cornea; Disulfiram; Ditioc

2007
Adverse effects of excessive nitric oxide on cytochrome c oxidase in lenses of hereditary cataract UPL rats.
    Toxicology, 2007, Dec-05, Volume: 242, Issue:1-3

    Topics: Adenosine Triphosphate; Administration, Oral; Animals; Cataract; Disease Models, Animal; Disulfiram;

2007
In vitro cell culture model for anti-cataract drug penetration studies.
    Die Pharmazie, 2007, Volume: 62, Issue:10

    Topics: Aldehyde Dehydrogenase; Animals; Cataract; Cell Line; Cell Membrane Permeability; Collagen Type IV;

2007
Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract ICR/f rats.
    Biological & pharmaceutical bulletin, 2008, Volume: 31, Issue:5

    Topics: Alcohol Deterrents; Animals; Calcium; Calcium-Transporting ATPases; Cataract; Cyclodextrins; Disulfi

2008
Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats.
    Current eye research, 1999, Volume: 18, Issue:4

    Topics: Administration, Intranasal; Animals; Cataract; Disulfiram; Ditiocarb; Drug Carriers; Female; Liposom

1999
Effects of lipid composition on the transcorneal penetration of liposomes containing disulfiram, a potential anti-cataract agent, in the rabbit.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:3

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Antioxidants; Calorimetry, Differential Scanning; Catar

2000
Preparation and in vivo ocular absorption studies of disulfiram solid dispersion.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:5

    Topics: Absorption; Animals; Cataract; Dimerization; Disulfiram; Ditiocarb; Drug Carriers; Drug Compounding;

2000