disulfiram has been researched along with Carcinoma, Hepatocellular in 13 studies
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The results showed that disulfiram enhanced sensitivity of human hepatocellular carcinoma cells to doxorubicin by 15-27-fold, and increased reactive oxygen species (ROS) production as well as caspase-dependent apoptosis." | 8.12 | Disulfiram enhances chemotherapeutic effects of doxorubicin liposomes against human hepatocellular carcinoma via activating ROS-induced cell stress response pathways. ( Fang, Z; Guo, X; Li, M; Li, T; Liang, M; Lin, H; Sun, F; Zhang, Y; Zhou, X, 2022) |
| " One such anti-alcoholic drug, disulfiram, with significant anti-cancer potential was studied for its efficacy against Hep3B cell lines, an in vitro model of hepatocellular carcinoma." | 7.83 | Anti-proliferative and apoptosis-triggering potential of disulfiram and disulfiram-loaded polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line. ( Hoda, M; Mohankumar, K; Pajaniradje, S; Rajagopalan, R; Shakya, G, 2016) |
| " In the present study, we investigated the effect of disulfiram (DSF), an inhibitor of aldehyde dehydrogenase, toward tumor-initiating hepatocellular carcinoma (HCC) cells." | 7.80 | Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners. ( Chiba, T; Hayashi, T; Iwama, A; Kaneko, S; Koide, S; Miyagi, S; Miyazaki, M; Motoyama, T; Nakatsura, T; Ogasawara, S; Ooka, Y; Oshima, M; Saraya, A; Suzuki, E; Tawada, A; Yamashita, T; Yokosuka, O; Yuki, K; Zen, Y, 2014) |
| "Disulfiram (DSF) has copper (Cu)-dependent anticancer properties in vitro and in vivo." | 5.48 | Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways. ( Li, TY; Li, Y; Liu, S; Wang, LH; Wang, YT; Wu, CF; Yang, JY; Yuan, XZ; Zhang, HT; Zhou, WL, 2018) |
| "The results showed that disulfiram enhanced sensitivity of human hepatocellular carcinoma cells to doxorubicin by 15-27-fold, and increased reactive oxygen species (ROS) production as well as caspase-dependent apoptosis." | 4.12 | Disulfiram enhances chemotherapeutic effects of doxorubicin liposomes against human hepatocellular carcinoma via activating ROS-induced cell stress response pathways. ( Fang, Z; Guo, X; Li, M; Li, T; Liang, M; Lin, H; Sun, F; Zhang, Y; Zhou, X, 2022) |
| " One such anti-alcoholic drug, disulfiram, with significant anti-cancer potential was studied for its efficacy against Hep3B cell lines, an in vitro model of hepatocellular carcinoma." | 3.83 | Anti-proliferative and apoptosis-triggering potential of disulfiram and disulfiram-loaded polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line. ( Hoda, M; Mohankumar, K; Pajaniradje, S; Rajagopalan, R; Shakya, G, 2016) |
| " In the present study, we investigated the effect of disulfiram (DSF), an inhibitor of aldehyde dehydrogenase, toward tumor-initiating hepatocellular carcinoma (HCC) cells." | 3.80 | Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners. ( Chiba, T; Hayashi, T; Iwama, A; Kaneko, S; Koide, S; Miyagi, S; Miyazaki, M; Motoyama, T; Nakatsura, T; Ogasawara, S; Ooka, Y; Oshima, M; Saraya, A; Suzuki, E; Tawada, A; Yamashita, T; Yokosuka, O; Yuki, K; Zen, Y, 2014) |
| "Disulfiram (DSF) has copper (Cu)-dependent anticancer properties in vitro and in vivo." | 1.48 | Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways. ( Li, TY; Li, Y; Liu, S; Wang, LH; Wang, YT; Wu, CF; Yang, JY; Yuan, XZ; Zhang, HT; Zhou, WL, 2018) |
| "Disulfiram is an aldehyde dehydrogenase inhibitor that was used to treat alcoholism and showed anticancer activity, but its anticancer mechanism remains unclear." | 1.39 | Disulfiram deregulates HIF-α subunits and blunts tumor adaptation to hypoxia in hepatoma cells. ( Cho, CH; Cho, K; Choi, YJ; Kim, MS; Park, HJ; Yun, JH, 2013) |
| "Cu2+ toxicity was examined in two hepatocellular carcinoma cell lines, HepG2 and Hep3B, with Hep3B cells containing an integrated hepatitis B virus genome." | 1.35 | Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease. ( Babushkin, T; Hait-Darshan, R; Malik, Z, 2009) |
| "Extracts of the hepatoma cells contained an enzymatic activity with an isoelectric point similar to that of ALDH1." | 1.29 | The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme. ( Crabb, DW; Dipple, KM; Malek, K; Stewart, MJ; Xiao, Q, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 2 (15.38) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 7 (53.85) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Ren, X | 1 |
| Li, Y | 2 |
| Zhou, Y | 1 |
| Hu, W | 1 |
| Yang, C | 2 |
| Jing, Q | 1 |
| Zhou, C | 1 |
| Wang, X | 2 |
| Hu, J | 1 |
| Wang, L | 1 |
| Yang, J | 1 |
| Wang, H | 1 |
| Xu, H | 1 |
| Li, H | 1 |
| Tong, X | 1 |
| Wang, Y | 1 |
| Du, J | 1 |
| Lin, H | 1 |
| Sun, F | 1 |
| Li, T | 1 |
| Zhang, Y | 1 |
| Guo, X | 1 |
| Li, M | 1 |
| Liang, M | 1 |
| Zhou, X | 1 |
| Fang, Z | 1 |
| Wang, LH | 1 |
| Zhang, HT | 1 |
| Wang, YT | 1 |
| Liu, S | 1 |
| Zhou, WL | 1 |
| Yuan, XZ | 1 |
| Li, TY | 1 |
| Wu, CF | 1 |
| Yang, JY | 1 |
| Hassan, I | 1 |
| Ebaid, H | 1 |
| Alhazza, IM | 1 |
| Al-Tamimi, J | 1 |
| Aman, S | 1 |
| Abdel-Mageed, AM | 1 |
| Park, HJ | 1 |
| Kim, MS | 1 |
| Cho, K | 1 |
| Yun, JH | 1 |
| Choi, YJ | 1 |
| Cho, CH | 1 |
| Chiba, T | 1 |
| Suzuki, E | 1 |
| Yuki, K | 1 |
| Zen, Y | 1 |
| Oshima, M | 1 |
| Miyagi, S | 1 |
| Saraya, A | 1 |
| Koide, S | 1 |
| Motoyama, T | 1 |
| Ogasawara, S | 1 |
| Ooka, Y | 1 |
| Tawada, A | 1 |
| Nakatsura, T | 1 |
| Hayashi, T | 1 |
| Yamashita, T | 1 |
| Kaneko, S | 1 |
| Miyazaki, M | 1 |
| Iwama, A | 1 |
| Yokosuka, O | 1 |
| Huang, H | 1 |
| Liao, Y | 1 |
| Liu, N | 1 |
| Hua, X | 1 |
| Cai, J | 1 |
| Long, H | 1 |
| Zhao, C | 1 |
| Chen, X | 1 |
| Lan, X | 1 |
| Zang, D | 1 |
| Wu, J | 1 |
| Li, X | 1 |
| Shi, X | 1 |
| Liu, J | 1 |
| Hoda, M | 1 |
| Pajaniradje, S | 1 |
| Shakya, G | 1 |
| Mohankumar, K | 1 |
| Rajagopalan, R | 1 |
| Goto, K | 1 |
| Kato, N | 1 |
| Chung, RT | 1 |
| Hait-Darshan, R | 1 |
| Babushkin, T | 1 |
| Malik, Z | 1 |
| Stewart, MJ | 1 |
| Malek, K | 1 |
| Xiao, Q | 1 |
| Dipple, KM | 1 |
| Crabb, DW | 1 |
| Liu, GY | 1 |
| Frank, N | 1 |
| Bartsch, H | 1 |
| Lin, JK | 1 |
| Chieco, P | 1 |
| Normanni, P | 1 |
| Moslen, MT | 1 |
| Maltoni, C | 1 |
13 other studies available for disulfiram and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Copper; Disulfiram; Ferroptosis; Humans; Kelch-Like ECH | 2021 |
Disulfiram enhances chemotherapeutic effects of doxorubicin liposomes against human hepatocellular carcinoma via activating ROS-induced cell stress response pathways.
Topics: Animals; Carcinoma, Hepatocellular; Cell Cycle Proteins; Cell Line, Tumor; Disulfiram; Doxorubicin; | 2022 |
Disulfiram combined with copper inhibits metastasis and epithelial-mesenchymal transition in hepatocellular carcinoma through the NF-κB and TGF-β pathways.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Copper; Disulfiram; Down-Regula | 2018 |
Copper Mediates Anti-Inflammatory and Antifibrotic Activity of Gleevec in Hepatocellular Carcinoma-Induced Male Rats.
Topics: Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Chelating Agents; Copper; Cytokines; Disu | 2019 |
Disulfiram deregulates HIF-α subunits and blunts tumor adaptation to hypoxia in hepatoma cells.
Topics: Adaptation, Physiological; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Hepatocellular; | 2013 |
Disulfiram eradicates tumor-initiating hepatocellular carcinoma cells in ROS-p38 MAPK pathway-dependent and -independent manners.
Topics: Aldehyde Dehydrogenase; Animals; Antigens, Neoplasm; Carcinogenesis; Carcinoma, Hepatocellular; Cell | 2014 |
Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo.
Topics: Aldehyde Dehydrogenase; Amino Acid Chloromethyl Ketones; Animals; Antineoplastic Agents; Antineoplas | 2016 |
Anti-proliferative and apoptosis-triggering potential of disulfiram and disulfiram-loaded polysorbate 80-stabilized PLGA nanoparticles on hepatocellular carcinoma Hep3B cell line.
Topics: Acetaldehyde Dehydrogenase Inhibitors; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Disul | 2016 |
Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro.
Topics: Alcohol Deterrents; Antineoplastic Agents; Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; C | 2016 |
Regulation of heme synthesis and proteasomal activity by copper: possible implications for Wilson's disease.
Topics: Adenosine Triphosphatases; Carcinoma, Hepatocellular; Cation Transport Proteins; Cell Line, Tumor; C | 2009 |
The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme.
Topics: Aldehyde Dehydrogenase; Blotting, Northern; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; | 1995 |
Induction of apoptosis by thiuramdisulfides, the reactive metabolites of dithiocarbamates, through coordinative modulation of NFkappaB, c-fos/c-jun, and p53 proteins.
Topics: Alcohol Deterrents; Antineoplastic Agents; Antioxidants; Apoptosis; Carcinoma, Hepatocellular; Cell | 1998 |
Quantitative histochemistry of benzaldehyde dehydrogenase in hepatocellular carcinomas of vinyl chloride-treated rats.
Topics: Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Animals; Benzaldehyde Dehydrogenase (NADP+); Benza | 1986 |