disulfiram and Addiction, Opioid studies

Research Excerpts

Excerpt	Relevance	Reference
"Disulfiram is a cocaine addiction pharmacotherapy that inhibits dopamine β-hydroxylase (DβH) and reduces norepinephrine production."	6.78	Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. ( Hamon, SC; Harding, MJ; Huang, W; Kosten, TR; Nielsen, DA; Shorter, D, 2013)
"Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possible mechanisms of efficacy is through copper chelation and inhibition of an enzyme involved in catecholamine metabolism, dopamine β-hydroxylase (DβH), which converts dopamine to norepinephrine."	6.78	Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase. ( Hamon, SC; Harding, MJ; Huang, W; Kosten, TR; Lappalainen, J; Nielsen, DA; Wu, G, 2013)
" Recent studies have evaluated disulfiram as a treatment for individuals with comorbid alcohol and cocaine abuse."	5.09	Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. ( Carroll, KM; Frankforter, T; Gordon, LT; McCance-Katz, EF; Nich, C; Petrakis, IL; Rounsaville, BJ, 2000)
" Clinical results using two blocking agents, naltrexone for opioid abuse and disulfiram for alcohol abuse, are reviewed as a source of leads in developing potential agents for treating sedative and stimulant abuse."	4.78	Pharmacological blocking agents for treating substance abuse. ( Kosten, TA; Kosten, TR, 1991)
"Alcoholism is a major problem among methadone maintenance patients."	4.77	The treatment of alcoholic methadone patients: a review. ( Bickel, WK; Lowinson, JH; Marion, I, 1987)
"Disulfiram may be efficacious for treating cocaine dependence or abuse, possibly through inhibiting dopamine β-hydroxylase (DβH)."	2.79	Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. ( Chawarski, MC; Cubells, JF; George, TP; Kosten, TR; Lappalainen, J; Schottenfeld, RS, 2014)
"Disulfiram is a cocaine addiction pharmacotherapy that inhibits dopamine β-hydroxylase (DβH) and reduces norepinephrine production."	2.78	Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. ( Hamon, SC; Harding, MJ; Huang, W; Kosten, TR; Nielsen, DA; Shorter, D, 2013)
"Disulfiram has been an effective cocaine addiction pharmacotherapy, and one of its possible mechanisms of efficacy is through copper chelation and inhibition of an enzyme involved in catecholamine metabolism, dopamine β-hydroxylase (DβH), which converts dopamine to norepinephrine."	2.78	Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase. ( Hamon, SC; Harding, MJ; Huang, W; Kosten, TR; Lappalainen, J; Nielsen, DA; Wu, G, 2013)
"Disulfiram was administered at a dosage of 125 mg/day for seven days and 250 mg/day thereafter for 36 weeks."	2.65	Use of disulfiram for alcoholics in methadone maintenance programs. A Veterans Administration Cooperative Study. ( Charuvastra, VC; Ling, W; O'Brien, CP; Weiss, DG, 1983)
"Opioid use disorders are serious contributors to the harms associated with the drug use."	1.62	Treatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats. ( Daniel, WA; Filip, M; Frankowska, M; Jastrzębska, J; Kleczkowska, P; Pieniążek, R; Pukło, R; Suder, A; Surówka, P; Zadrożny-Bujalska, M, 2021)
"Unfortunately, treatment of opioid dependence is difficult, particularly because of codependence - for example, on alcohol or other drugs of abuse."	1.48	Disulfiram attenuates morphine or methadone withdrawal syndrome in mice. ( Bujalska-Zadrożny, M; de Cordé, A; Filip, M; Kleczkowska, P; Krząścik, P; Wolińska, R, 2018)
"Disulfiram appears to be a useful adjunct for drug abusers with serious alcohol problems."	1.27	Brief effective treatment strategies: pharmacological therapy for opiate addicts. ( Kleber, HD, 1985)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (16.67)	18.7374
1990's	2 (11.11)	18.2507
2000's	5 (27.78)	29.6817
2010's	6 (33.33)	24.3611
2020's	2 (11.11)	2.80

Authors	Studies
Thomas, PS	1
Nielsen, EM	1
Spellicy, CJ	1
Harding, MJ	3
Ye, A	1
Patriquin, M	1
Hamon, SC	3
Kosten, TR	6
Nielsen, DA	3
Frankowska, M	1
Surówka, P	1
Suder, A	1
Pieniążek, R	1
Pukło, R	1
Jastrzębska, J	1
Daniel, WA	1
Filip, M	2
Zadrożny-Bujalska, M	1
Kleczkowska, P	2
de Cordé, A	1
Krząścik, P	1
Wolińska, R	1
Bujalska-Zadrożny, M	1
Shorter, D	1
Huang, W	2
Schottenfeld, RS	1
Chawarski, MC	1
Cubells, JF	2
George, TP	1
Lappalainen, J	2
Mark, TL	1
Kassed, CA	1
Vandivort-Warren, R	1
Levit, KR	1
Kranzler, HR	1
Simkin, DR	1
Grenoble, S	1
Oliveto, A	1
Poling, J	1
Mancino, MJ	1
Feldman, Z	1
Pruzinsky, R	1
Gonsai, K	1
Cargile, C	1
Sofuoglu, M	1
Chopra, MP	1
Gonzalez-Haddad, G	1
Carroll, KM	3
Wu, G	1
Jofre-Bonet, M	1
Sindelar, JL	1
Petrakis, IL	2
Nich, C	2
Frankforter, T	2
Rounsaville, BJ	2
Stenbacka, M	1
Beck, O	1
Leifman, A	1
Romelsjö, A	1
Helander, A	1
Horgan, CM	1
Reif, S	1
Hodgkin, D	1
Garnick, DW	1
Merrick, EL	1
Ling, W	1
Weiss, DG	1
Charuvastra, VC	1
O'Brien, CP	1
Brewer, C	1
Gordon, LT	1
McCance-Katz, EF	1
Kosten, TA	1
Kleber, HD	1
Bickel, WK	1
Marion, I	1
Lowinson, JH	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Effectiveness of Disulfiram for Treating Cocaine Dependence in Individuals With Different Dopamine Beta Hydroxylase (DBH) Genes[NCT00149630]	Phase 2	93 participants (Actual)	Interventional	2005-01-31	Completed
Treatment for Alcohol Dependence With Gabapentin: A Double Blind Placebo Controlled Randomized Clinical Trial[NCT02771925]	Phase 4	25 participants (Actual)	Interventional	2016-06-30	Terminated (stopped due to Due to poor compliance of patients in the study.)
Test of a Workforce Development Intervention to Expand Buprenorphine Prescribers[NCT02926482]		76 participants (Actual)	Interventional	2016-10-26	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Treatment retention for full 12 weeks of study. (NCT00149630)
Timeframe: 12 weeks

Intervention	% cocaine + urines over 2 week blocks (Mean)
Placebo CC	84
Placebo CT/TT	68
Disulfiram CC	56
Disulfiram CT/TT	67

Article	Year
Pharmacotherapies for adolescent substance use disorders. Child and adolescent psychiatric clinics of North America, 2010, Volume: 19, Issue:3 Topics: Adolescent; Alcohol Deterrents; Alcoholism; Cocaine-Related Disorders; Disulfiram; Humans; Marijuana	2010
Pharmacological blocking agents for treating substance abuse. The Journal of nervous and mental disease, 1991, Volume: 179, Issue:10 Topics: Alcoholism; Animals; Behavior Therapy; Disulfiram; Drug Antagonism; Drug Design; Humans; Naltrexone;	1991
The treatment of alcoholic methadone patients: a review. Journal of substance abuse treatment, 1987, Volume: 4, Issue:1 Topics: Alcoholism; Behavior Therapy; Combined Modality Therapy; Disulfiram; Humans; Methadone; Opioid-Relat	1987

Article	Year
The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Psychiatric genetics, 2021, 06-01, Volume: 31, Issue:3 Topics: Adult; Alleles; Cocaine; Cocaine-Related Disorders; Disulfiram; Female; Genotype; Humans; Male; Meth	2021
Pharmacogenetic randomized trial for cocaine abuse: disulfiram and α1A-adrenoceptor gene variation. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2013, Volume: 23, Issue:11 Topics: Adult; Alcohol Deterrents; Alleles; Cocaine-Related Disorders; Disulfiram; Dopamine beta-Hydroxylase	2013
Randomized clinical trial of disulfiram for cocaine dependence or abuse during buprenorphine treatment. Drug and alcohol dependence, 2014, Mar-01, Volume: 136 Topics: Adolescent; Adult; Alcohol Deterrents; Alcoholism; Alleles; Buprenorphine; Cocaine-Related Disorders	2014
Randomized, double blind, placebo-controlled trial of disulfiram for the treatment of cocaine dependence in methadone-stabilized patients. Drug and alcohol dependence, 2011, Jan-15, Volume: 113, Issue:2-3 Topics: Adult; Alcohol Drinking; Cocaine; Cocaine-Related Disorders; Cognitive Behavioral Therapy; Disulfira	2011
Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase. Biological psychiatry, 2013, Feb-01, Volume: 73, Issue:3 Topics: Adult; Cocaine-Related Disorders; Disulfiram; Dopamine beta-Hydroxylase; Drug Therapy, Combination;	2013
Cost effectiveness of disulfiram: treating cocaine use in methadone-maintained patients. Journal of substance abuse treatment, 2004, Volume: 26, Issue:3 Topics: Adult; Analgesics, Opioid; Cocaine-Related Disorders; Connecticut; Cost-Benefit Analysis; Disulfiram	2004
Use of disulfiram for alcoholics in methadone maintenance programs. A Veterans Administration Cooperative Study. Archives of general psychiatry, 1983, Volume: 40, Issue:8 Topics: Adult; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Disulfiram; Double-Blind Method; Drug	1983
Disulfiram treatment for cocaine dependence in methadone-maintained opioid addicts. Addiction (Abingdon, England), 2000, Volume: 95, Issue:2 Topics: Cocaine-Related Disorders; Disulfiram; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Male;	2000

Article	Year
Treatment with dopamine β-hydroxylase (DBH) inhibitors prevents morphine use and relapse-like behavior in rats. Pharmacological reports : PR, 2021, Volume: 73, Issue:6 Topics: Animals; Disulfiram; Dopamine; Dopamine beta-Hydroxylase; Drug-Seeking Behavior; Enzyme Inhibitors;	2021
Disulfiram attenuates morphine or methadone withdrawal syndrome in mice. Behavioural pharmacology, 2018, Volume: 29, Issue:5 Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disulfiram; Male; Methadone; Mice; Mice, Inbred C57BL	2018
Alcohol and opioid dependence medications: prescription trends, overall and by physician specialty. Drug and alcohol dependence, 2009, Jan-01, Volume: 99, Issue:1-3 Topics: Acamprosate; Alcohol Deterrents; Alcoholism; Buprenorphine; Delayed-Action Preparations; Disulfiram;	2009
Problem drinking in relation to treatment outcome among opiate addicts in methadone maintenance treatment. Drug and alcohol review, 2007, Volume: 26, Issue:1 Topics: Adult; Alcohol Deterrents; Alcoholism; Comorbidity; Cyanamide; Disulfiram; Female; Follow-Up Studies	2007
Availability of addiction medications in private health plans. Journal of substance abuse treatment, 2008, Volume: 34, Issue:2 Topics: Alcohol Deterrents; Alcoholism; Buprenorphine; Cost Sharing; Data Collection; Disulfiram; Drugs, Gen	2008
Alcohol-abusing methadone patients. Alcoholism, clinical and experimental research, 1994, Volume: 18, Issue:3 Topics: Alcoholism; Combined Modality Therapy; Comorbidity; Disulfiram; Humans; Methadone; Opioid-Related Di	1994
Brief effective treatment strategies: pharmacological therapy for opiate addicts. NIDA research monograph, 1985, Volume: 58 Topics: Alcoholism; Anti-Anxiety Agents; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Disulfiram;	1985

disulfiram and Addiction, Opioid

Research Excerpts

Research

Studies (18)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Retention by Treatment Condition.

Urine Toxicology for Cocaine.

Reviews

Trials

Other Studies

Intervention	% of subjects who complete 12 wks study (Number)
Disulfiram	77
Placebo	87