disopyramide has been researched along with Seizures in 6 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "SUN 1165 had no effect on clonic convulsions induced by pentetrazol and pictrotoxin in mice, while both mexiletine and lidocaine prolonged the duration of clonic convulsions." | 1.27 | General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system. ( Hashimoto, Y; Hatta, M; Hattori, Y; Hirotsu, I; Ishihara, T; Kihara, T; Kitakaze, Y; Miyata, T; Nakamura, S; Takahama, K, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Dawidowski, M | 2 |
| Król, M | 2 |
| Szulczyk, B | 2 |
| Chodkowski, A | 1 |
| Podsadni, P | 2 |
| Konopelski, P | 1 |
| Ufnal, M | 2 |
| Szuberski, P | 1 |
| Wróbel, MZ | 1 |
| Zhang, Y | 1 |
| El Harchi, A | 1 |
| Hancox, JC | 1 |
| Jarkovska, D | 1 |
| Mistrova, E | 1 |
| Sviglerova, J | 1 |
| Štengl, M | 1 |
| Popowicz, GM | 1 |
| Turło, J | 2 |
| Drapała, A | 1 |
| Malavé, A | 1 |
| Holsapple, MP | 1 |
| Yim, GK | 1 |
| O'Keefe, B | 1 |
| Holt, DW | 2 |
| Hayler, AM | 2 |
| Medd, RK | 2 |
| O'Keeffe, B | 1 |
| Hirotsu, I | 1 |
| Kihara, T | 1 |
| Nakamura, S | 1 |
| Hattori, Y | 1 |
| Hatta, M | 1 |
| Kitakaze, Y | 1 |
| Takahama, K | 1 |
| Hashimoto, Y | 1 |
| Miyata, T | 1 |
| Ishihara, T | 1 |
6 other studies available for disopyramide and Seizures
| Article | Year |
|---|---|
Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide.
Topics: Acetamides; Animals; Anticonvulsants; Disopyramide; Dose-Response Relationship, Drug; Electroshock; | 2020 |
Characterization of Disopyramide derivative ADD424042 as a non-cardiotoxic neuronal sodium channel blocker with broad-spectrum anticonvulsant activity in rodent seizure models.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Disopyramide; Electrocardi | 2016 |
Local anesthetic activity and disopyramide toxicity.
Topics: Action Potentials; Anesthetics, Local; Animals; Disopyramide; In Vitro Techniques; Lethal Dose 50; M | 1983 |
Convulsion after disopyramide.
Topics: Disopyramide; Drug Evaluation; Humans; Pyridines; Seizures | 1978 |
Treatment of disopyramide overdosage.
Topics: Antidotes; Bradycardia; Disopyramide; Humans; Isoproterenol; Pyridines; Seizures | 1979 |
General pharmacological studies on N-(2,6-dimethylphenyl)-8-pyrrolizidineacetamide hydrochloride hemihydrate. 1st communication: effect on the central nervous system.
Topics: Administration, Oral; Animals; Anti-Arrhythmia Agents; Body Temperature; Catalepsy; Cats; Central Ne | 1988 |