disopyramide has been researched along with Hypokalemia in 6 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Disopyramide was metabolized by the cytochrome enzyme CYP3A4 and clarithromycin competitively inhibits this enzyme, probably resulting in an increase in plasma concentration of disopyramide." | 5.30 | Torsades de pointes ventricular tachycardia induced by clarithromycin and disopyramide in the presence of hypokalemia. ( Hashimoto, T; Hayashi, Y; Ikeda, U; Mitsuhashi, T; Shimada, K; Watanabe, T, 1999) |
| "Disopyramide was metabolized by the cytochrome enzyme CYP3A4 and clarithromycin competitively inhibits this enzyme, probably resulting in an increase in plasma concentration of disopyramide." | 1.30 | Torsades de pointes ventricular tachycardia induced by clarithromycin and disopyramide in the presence of hypokalemia. ( Hashimoto, T; Hayashi, Y; Ikeda, U; Mitsuhashi, T; Shimada, K; Watanabe, T, 1999) |
| "The potential antiarrhythmic and electrophysiological effects of prolonged oral dosing with amiodarone (20 mg/kg/day) or disopyramide (25 or 50 mg/kg b." | 1.27 | Effects of diet-induced hypokalaemia on the antiarrhythmic and electrophysiological actions of prolonged oral treatment with either amiodarone or disopyramide in the anaesthetised rat. ( Hope, FG; Marshall, RJ; Winslow, E, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miyamoto, K | 1 |
| Kawai, H | 1 |
| Aoyama, R | 1 |
| Watanabe, H | 1 |
| Suzuki, K | 1 |
| Suga, N | 1 |
| Kitagawa, W | 1 |
| Miura, N | 1 |
| Nishikawa, K | 1 |
| Imai, H | 1 |
| Hayashi, Y | 1 |
| Ikeda, U | 1 |
| Hashimoto, T | 1 |
| Watanabe, T | 1 |
| Mitsuhashi, T | 1 |
| Shimada, K | 1 |
| Barrillon, A | 1 |
| Grand, A | 1 |
| Casedevant, B | 1 |
| Sabaut, D | 1 |
| Clementy, J | 1 |
| Dallocchio, M | 1 |
| Winslow, E | 1 |
| Marshall, RJ | 1 |
| Hope, FG | 1 |
| Nanimatsu, H | 1 |
| Shibayama, H | 1 |
| Koumatsu, A | 1 |
| Inoue, T | 1 |
| Maeda, T | 1 |
| Saikawa, T | 1 |
| Ito, S | 1 |
| Takaki, R | 1 |
| Tsunematsu, Y | 1 |
1 review available for disopyramide and Hypokalemia
| Article | Year |
|---|---|
[Incompatibility and interference of the major cardiologic drugs. Their undesirable effects].
Topics: Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antihypertensive Agents; Bradycardia; Cardiac Glyc | 1976 |
5 other studies available for disopyramide and Hypokalemia
| Article | Year |
|---|---|
Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.
Topics: Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Cytochrome P-450 CYP3A; Disopyrami | 2010 |
Torsades de pointes ventricular tachycardia induced by clarithromycin and disopyramide in the presence of hypokalemia.
Topics: Aged; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Arrhythmias, Cardiac; Clarithromycin; Cytochrom | 1999 |
[Letter: Syncopes through the inversion of points in connection with the absorption of disopyramide].
Topics: Arrhythmias, Cardiac; Coronary Disease; Disopyramide; Female; Humans; Hypertension; Hypokalemia; Mid | 1975 |
Effects of diet-induced hypokalaemia on the antiarrhythmic and electrophysiological actions of prolonged oral treatment with either amiodarone or disopyramide in the anaesthetised rat.
Topics: Amiodarone; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Diet; Disopyramid | 1987 |
[Three cases of Torsades de pointes].
Topics: Adult; Aged; Aged, 80 and over; Disopyramide; Electrocardiography; Female; Humans; Hypokalemia; Male | 1989 |