disopyramide has been researched along with Electrocardiogram QT Prolonged in 15 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study suggests that the patients showing bradycardia dependent QT prolongation are also more markedly affected by disopyramide and that abnormal potassium channel may be the underlying mechanism." | 7.70 | Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans. ( Abe, A; Aizawa, Y; Chinushi, M; Furushima, H; Niwano, S; Ohhira, K, 1998) |
| "This study suggests that the patients showing bradycardia dependent QT prolongation are also more markedly affected by disopyramide and that abnormal potassium channel may be the underlying mechanism." | 3.70 | Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans. ( Abe, A; Aizawa, Y; Chinushi, M; Furushima, H; Niwano, S; Ohhira, K, 1998) |
| "disopyramide was administered intra-vascularly in separate experiments, and the doses were predicted only from the pharmacological data." | 1.31 | Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat. ( Iwanaga, K; Kakemi, M; Maekawa, C; Miyazaki, M; Morimoto, K, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.67) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 6 (40.00) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hirose, K | 1 |
| Yamaguchi, H | 1 |
| Oshima, Y | 1 |
| Choraku, M | 1 |
| Hirono, A | 1 |
| Takamori, N | 1 |
| Tamura, K | 2 |
| Matsuhashi, T | 1 |
| Sato, T | 1 |
| Aizawa, Y | 2 |
| Takatsuki, S | 1 |
| Asajima, H | 1 |
| Saito, N | 1 |
| Ohmura, Y | 1 |
| Ohmura, K | 1 |
| Yoshida, H | 1 |
| Sugiyama, A | 1 |
| Satoh, Y | 1 |
| Ishida, Y | 1 |
| Kugiyama, K | 1 |
| Hashimoto, K | 1 |
| Ridley, JM | 1 |
| Milnes, JT | 1 |
| Benest, AV | 1 |
| Masters, JD | 1 |
| Witchel, HJ | 1 |
| Hancox, JC | 1 |
| Hanada, E | 1 |
| Ohtani, H | 1 |
| Hirota, M | 1 |
| Uemura, N | 1 |
| Nakaya, H | 1 |
| Kotaki, H | 1 |
| Sato, H | 1 |
| Yamada, Y | 1 |
| Iga, T | 1 |
| Dumaine, R | 1 |
| Antzelevitch, C | 1 |
| Kurita, T | 1 |
| Ohe, T | 1 |
| Shimizu, W | 1 |
| Suyama, K | 1 |
| Aihara, N | 1 |
| Takaki, H | 1 |
| Kamakura, S | 1 |
| Shimomura, K | 1 |
| Panhuyzen-Goedkoop, NM | 1 |
| Crijns, HJ | 1 |
| Wolff, GS | 1 |
| Furushima, H | 1 |
| Niwano, S | 1 |
| Chinushi, M | 1 |
| Ohhira, K | 1 |
| Abe, A | 1 |
| Matsunaga, T | 1 |
| Mitsui, T | 1 |
| Harada, T | 1 |
| Inokuma, M | 1 |
| Murano, H | 1 |
| Shibutani, Y | 1 |
| Miyazaki, M | 1 |
| Maekawa, C | 1 |
| Iwanaga, K | 1 |
| Morimoto, K | 1 |
| Kakemi, M | 1 |
| Kasanuki, H | 1 |
| Ohnishi, S | 1 |
| Nirei, T | 1 |
| Shoda, M | 1 |
| Hosoda, S | 1 |
| Gardner, MJ | 1 |
| McCarthy, DM | 1 |
| Josephson, ME | 1 |
1 review available for disopyramide and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Unexplained syncope: clinical management.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Behavior Ther | 1997 |
14 other studies available for disopyramide and Electrocardiogram QT Prolonged
| Article | Year |
|---|---|
Severe respiratory failure and torsades de pointes induced by disopyramide in a patient with myasthenia gravis.
Topics: Anti-Arrhythmia Agents; Atrial Fibrillation; Cholinergic Antagonists; Disopyramide; Electrocardiogra | 2008 |
Recurrent Torsade de Pointes during mild hypothermia therapy for a survivor of sudden cardiac arrest due to drug-induced long-QT syndrome.
Topics: Aged; Anti-Arrhythmia Agents; Disopyramide; Female; Heart Arrest; Humans; Hypothermia, Induced; Long | 2010 |
Lansoprazole precipitated QT prolongation and torsade de pointes associated with disopyramide.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Anti-Arrhythmia Agents; Anti-Ulcer Agents; Disopyrami | 2012 |
Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac | 2002 |
Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.
Topics: Anti-Arrhythmia Agents; Cation Transport Proteins; Cell Line; Cell Membrane; Disopyramide; DNA-Bindi | 2003 |
Inhibitory effect of erythromycin on potassium currents in rat ventricular myocytes in comparison with disopyramide.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Delayed Rectifier Potassi | 2003 |
Disopyramide: although potentially life-threatening in the setting of long QT, could it be life-saving in short QT syndrome?
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Disopyramide; Drug Interaction | 2006 |
Early afterdepolarizationlike activity in patients with class IA induced long QT syndrome and torsades de pointes.
Topics: Action Potentials; Aged; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Electrophysiolog | 1997 |
[Iatrogenic collapse; can this be prevented?].
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Disopyramide; Erythro | 1997 |
Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Bradycardia; Cardiac Pacing, Artificial; Dis | 1998 |
QT corrected for heart rate and relation between QT and RR intervals in beagle dogs.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Disopyramide; Dogs; Electrocardiography, Am | 1997 |
Bioavailability assessment of disopyramide using pharmacokinetic-pharmacodynamic (PK-PD) modeling in the rat.
Topics: Algorithms; Animals; Anti-Arrhythmia Agents; Antifungal Agents; Area Under Curve; Biological Availab | 2000 |
Acquired long QT syndrome due to antiarrhythmic drugs and bradyarrhythmias.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Bradycardia; Disopyramide; Electrocardiograp | 1992 |
Effect of myocardial ischemia and type I antiarrhythmic drug therapy on exercise QT intervals.
Topics: Anti-Arrhythmia Agents; Coronary Disease; Disopyramide; Electrocardiography; Exercise Test; Heart Co | 1985 |