disopyramide has been researched along with Drop Attack in 35 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A double-blind randomized trial was designed to determine the efficacy of intravenous and oral disopyramide phosphate in preventing neurally mediated syncope induced by a head-up tilt test." | 9.07 | A placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt. ( Klein, GJ; Leitch, JW; Morillo, CA; Yee, R, 1993) |
| "Low dose disopyramide has been used to prevent neurally-mediated syncope during head-up tilt testing but a correlation between blood levels and efficacy has not been described." | 7.69 | Low dose disopyramide often fails to prevent neurogenic syncope during head-up tilt testing. ( Adler, SW; Fuenzalida, CE; Kelly, PA; Mann, DE; Reiter, MJ, 1994) |
| "Susceptibility to transient hypotension-bradycardia of neurally mediated origin has been attributed in part to accentuated afferent neural traffic arising from cardiopulmonary mechanoreceptors, and consequently, may be diminished by agents with anticholinergic and negative inotropic effects, such as disopyramide phosphate." | 7.68 | Usefulness of disopyramide for prevention of upright tilt-induced hypotension-bradycardia. ( Benditt, DG; Buetikofer, J; Dunnigan, A; Gornick, C; Milstein, S; Reyes, WJ, 1990) |
| "Seventeen patients with recurrent symptomatic arrhythmias were treated with oral disopyramide (DP)." | 7.66 | Clinical and electrophysiological observations with disopyramide in drug-resistant and recurrent symptomatic arrhythmias. ( Millar, RN; Myers, JB; Obel, IW, 1978) |
| "The management of syncope is clinically important for heart failure (HF) patients." | 5.72 | [Evaluation of Disopyramide Efficacy for Refractory Syncope in Heart Failure with Preserved Ejection Fraction Using Holter Electrocardiography: A Case Report]. ( Asai, Y; Sato, Y; Shintani, T; Yamamoto, T, 2022) |
| "A double-blind randomized trial was designed to determine the efficacy of intravenous and oral disopyramide phosphate in preventing neurally mediated syncope induced by a head-up tilt test." | 5.07 | A placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt. ( Klein, GJ; Leitch, JW; Morillo, CA; Yee, R, 1993) |
| "Twenty-five patients with recurrent unexplained syncope and six control subjects were evaluated by use of an upright tilt-table test for 30 minutes, with or without an infusion of isoproterenol (1 to 3 micrograms/minute given intravenously), in an attempt to provoke bradycardia, hypotension, or both." | 5.07 | Utility of upright tilt-table testing in the evaluation and management of syncope of unknown origin. ( Elliott, L; Grubb, BP; Hahn, H; Temesy-Armos, P, 1991) |
| "Administration of disopyramide was effective in preventing syncope." | 4.02 | Frequent occurrence of postbreakfast syncope due to carotid sinus syndrome after surgery for hypopharyngeal cancer: A case report. ( Ando, Y; Fujita, N; Hashimoto, K; Obuchi, Y; Ono, Y; Sano, A; Tanaka, Y; Tatsushima, D; Tomifuji, M; Watanabe, S; Yanagawa, R, 2021) |
| "Low dose disopyramide has been used to prevent neurally-mediated syncope during head-up tilt testing but a correlation between blood levels and efficacy has not been described." | 3.69 | Low dose disopyramide often fails to prevent neurogenic syncope during head-up tilt testing. ( Adler, SW; Fuenzalida, CE; Kelly, PA; Mann, DE; Reiter, MJ, 1994) |
| "Syncope occurred in nine patients (36%) during the baseline tilt and in seven patients (28%) during isoproterenol infusion (total positives 64%)." | 3.68 | Recurrent unexplained syncope in the elderly: the use of head-upright tilt table testing in evaluation and management. ( Elliott, L; Grubb, BP; Hahn, H; Madu, E; Samoil, D; Temesy-Armos, P; Wolfe, D, 1992) |
| "Susceptibility to transient hypotension-bradycardia of neurally mediated origin has been attributed in part to accentuated afferent neural traffic arising from cardiopulmonary mechanoreceptors, and consequently, may be diminished by agents with anticholinergic and negative inotropic effects, such as disopyramide phosphate." | 3.68 | Usefulness of disopyramide for prevention of upright tilt-induced hypotension-bradycardia. ( Benditt, DG; Buetikofer, J; Dunnigan, A; Gornick, C; Milstein, S; Reyes, WJ, 1990) |
| "Seventeen patients with recurrent symptomatic arrhythmias were treated with oral disopyramide (DP)." | 3.66 | Clinical and electrophysiological observations with disopyramide in drug-resistant and recurrent symptomatic arrhythmias. ( Millar, RN; Myers, JB; Obel, IW, 1978) |
| "The management of syncope is clinically important for heart failure (HF) patients." | 1.72 | [Evaluation of Disopyramide Efficacy for Refractory Syncope in Heart Failure with Preserved Ejection Fraction Using Holter Electrocardiography: A Case Report]. ( Asai, Y; Sato, Y; Shintani, T; Yamamoto, T, 2022) |
| "Initiation of disopyramide in the outpatient setting is safe and the risk of subsequent sudden cardiac death is low." | 1.46 | Safety of Outpatient Initiation of Disopyramide for Obstructive Hypertrophic Cardiomyopathy Patients. ( Adler, A; Chan, RH; Fourey, D; Gollob, MH; Hindieh, W; Rakowski, H; Weissler-Snir, A, 2017) |
| "We conclude that chronic fatigue syndrome is associated with neurally mediated hypotension and that its symptoms may be improved in a subset of patients by therapy directed at this abnormal cardiovascular reflex." | 1.29 | The relationship between neurally mediated hypotension and the chronic fatigue syndrome. ( Bou-Holaigah, I; Calkins, H; Kan, J; Rowe, PC, 1995) |
| "Neurally mediated hypotension is now recognised as a common cause of otherwise unexplained recurrent syncope, but has not been reported in association with chronic fatigue." | 1.29 | Is neurally mediated hypotension an unrecognised cause of chronic fatigue? ( Bou-Holaigah, I; Calkins, H; Kan, JS; Rowe, PC, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (25.71) | 18.7374 |
| 1990's | 18 (51.43) | 18.2507 |
| 2000's | 4 (11.43) | 29.6817 |
| 2010's | 1 (2.86) | 24.3611 |
| 2020's | 3 (8.57) | 2.80 |
| Authors | Studies |
|---|---|
| Asai, Y | 1 |
| Shintani, T | 1 |
| Yamamoto, T | 1 |
| Sato, Y | 1 |
| Rowin, EJ | 1 |
| Sridharan, A | 1 |
| Madias, C | 1 |
| Firely, C | 1 |
| Koethe, B | 1 |
| Link, MS | 1 |
| Maron, MS | 1 |
| Maron, BJ | 1 |
| Ando, Y | 1 |
| Hashimoto, K | 1 |
| Sano, A | 1 |
| Fujita, N | 1 |
| Yanagawa, R | 1 |
| Ono, Y | 1 |
| Obuchi, Y | 1 |
| Tatsushima, D | 1 |
| Watanabe, S | 1 |
| Tomifuji, M | 1 |
| Tanaka, Y | 1 |
| Adler, A | 1 |
| Fourey, D | 1 |
| Weissler-Snir, A | 1 |
| Hindieh, W | 1 |
| Chan, RH | 1 |
| Gollob, MH | 1 |
| Rakowski, H | 1 |
| Hirai, Y | 1 |
| Yamamoto, H | 1 |
| Nakano, Y | 1 |
| Ogi, H | 1 |
| Kajiwara, S | 1 |
| Kohno, N | 1 |
| Eleftheriadis, D | 1 |
| Panagiotis, V | 1 |
| Eleftheriadis, N | 1 |
| Verma, S | 1 |
| Hackel, JG | 1 |
| Torrisi, DJ | 1 |
| Nguyen, T | 1 |
| Manolas, EG | 1 |
| Hunt, D | 1 |
| Sloman, G | 1 |
| Swiryn, S | 1 |
| Bauernfeind, RA | 1 |
| Strasberg, B | 1 |
| Palileo, E | 1 |
| Iverson, N | 1 |
| Levy, PS | 1 |
| Rosen, KM | 1 |
| Ko, PT | 1 |
| Gulamhusein, S | 1 |
| Kostuk, WJ | 1 |
| Klein, GJ | 3 |
| Schöttelndreiër, MA | 1 |
| Kelly, PA | 1 |
| Mann, DE | 1 |
| Adler, SW | 1 |
| Fuenzalida, CE | 1 |
| Reiter, MJ | 1 |
| Natale, A | 1 |
| Sra, J | 1 |
| Dhala, A | 2 |
| Wase, A | 1 |
| Jazayeri, M | 1 |
| Deshpande, S | 2 |
| Blanck, Z | 2 |
| Akhtar, M | 2 |
| Morillo, CA | 2 |
| Ellenbogen, KA | 1 |
| Grubb, BP | 4 |
| Kosinski, D | 2 |
| Samoil, D | 2 |
| Pothoulakis, A | 2 |
| Lorton, M | 1 |
| Kip, K | 1 |
| Bou-Holaigah, I | 2 |
| Rowe, PC | 2 |
| Kan, J | 1 |
| Calkins, H | 3 |
| Seifert, M | 1 |
| Morady, F | 1 |
| Kan, JS | 1 |
| Sneddon, JF | 1 |
| Scalia, G | 1 |
| Ward, DE | 1 |
| McKenna, WJ | 1 |
| Camm, AJ | 1 |
| Frenneaux, MP | 1 |
| Makkar, RR | 1 |
| Fromm, BS | 1 |
| Steinman, RT | 1 |
| Meissner, MD | 1 |
| Lehmann, MH | 1 |
| Leitch, JW | 1 |
| Yee, R | 1 |
| Sra, JS | 1 |
| Jazayeri, MR | 1 |
| Avitall, B | 1 |
| Mouhaffel, A | 1 |
| Panhuyzen-Goedkoop, NM | 1 |
| Crijns, HJ | 1 |
| Wolff, GS | 1 |
| Takagi, M | 1 |
| Aihara, N | 1 |
| Takaki, H | 1 |
| Taguchi, A | 1 |
| Shimizu, W | 1 |
| Kurita, T | 1 |
| Suyama, K | 1 |
| Kamakura, S | 1 |
| Hayler, AM | 1 |
| Holt, DW | 1 |
| Volans, GN | 1 |
| Tri, TB | 1 |
| Myers, JB | 1 |
| Millar, RN | 1 |
| Obel, IW | 1 |
| Casedevant, B | 1 |
| Sabaut, D | 1 |
| Clementy, J | 1 |
| Dallocchio, M | 1 |
| Wolfe, D | 1 |
| Madu, E | 1 |
| Temesy-Armos, P | 2 |
| Hahn, H | 2 |
| Elliott, L | 2 |
| Suzuki, K | 1 |
| Milstein, S | 1 |
| Buetikofer, J | 1 |
| Dunnigan, A | 1 |
| Benditt, DG | 1 |
| Gornick, C | 1 |
| Reyes, WJ | 1 |
| den Dulk, K | 1 |
| Lindemans, FW | 1 |
| Brugada, P | 1 |
| Smeets, JL | 1 |
| Wellens, HJ | 1 |
3 reviews available for disopyramide and Drop Attack
| Article | Year |
|---|---|
Syncope in athletes: a guide to getting them back on their feet.
Topics: Adolescent; Anti-Arrhythmia Agents; Diagnosis, Differential; Disopyramide; Electrocardiography; Exer | 2007 |
Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amiodarone; Bepridil; Cardiovascular Agents; Disopyramid | 1993 |
Unexplained syncope: clinical management.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Behavior Ther | 1997 |
4 trials available for disopyramide and Drop Attack
| Article | Year |
|---|---|
Effects of quinidine and disopyramide on serum digoxin concentrations.
Topics: Adult; Aged; Arrhythmias, Cardiac; Digoxin; Disopyramide; Drug Interactions; Female; Humans; Male; M | 1980 |
Efficacy of different treatment strategies for neurocardiogenic syncope.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Disopyramide; Ephedrine; Fe | 1995 |
A placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt.
Topics: Administration, Oral; Adult; Disopyramide; Double-Blind Method; Female; Follow-Up Studies; Humans; I | 1993 |
Utility of upright tilt-table testing in the evaluation and management of syncope of unknown origin.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Aged, 80 and over; Disopyramide; Female; Human | 1991 |
28 other studies available for disopyramide and Drop Attack
| Article | Year |
|---|---|
[Evaluation of Disopyramide Efficacy for Refractory Syncope in Heart Failure with Preserved Ejection Fraction Using Holter Electrocardiography: A Case Report].
Topics: Aged, 80 and over; Disopyramide; Electrocardiography, Ambulatory; Heart Failure; Humans; Male; Strok | 2022 |
Prediction and Prevention of Sudden Death in Young Patients (<20 years) With Hypertrophic Cardiomyopathy.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Calcium Channel Blockers; Ca | 2020 |
Frequent occurrence of postbreakfast syncope due to carotid sinus syndrome after surgery for hypopharyngeal cancer: A case report.
Topics: Aged; Anastomosis, Surgical; Breakfast; Carotid Sinus; Deglutition; Disopyramide; Electrocardiograph | 2021 |
Safety of Outpatient Initiation of Disopyramide for Obstructive Hypertrophic Cardiomyopathy Patients.
Topics: Action Potentials; Aged; Ambulatory Care; Anti-Arrhythmia Agents; Cardiomyopathy, Hypertrophic; Data | 2017 |
Disopyramide for transient high-degree atrioventricular block in a young patient with a history of syncope.
Topics: Adult; Anti-Arrhythmia Agents; Atrioventricular Block; Disopyramide; Electrocardiography, Ambulatory | 2008 |
Recurrent syncopic episodes as a consequence of combined Brugada syndrome and paroxysmal atrial fibrillation. Which is the therapy of choice?
Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Bundle-Branch Block; Disopyramide; Female; Humans | 2004 |
Prediction of response to class I antiarrhythmic drugs during electrophysiologic study of ventricular tachycardia.
Topics: Adolescent; Adult; Aged; Anti-Arrhythmia Agents; Disopyramide; Dose-Response Relationship, Drug; Ele | 1982 |
Torsades de pointes, a common arrhythmia, induced by medication.
Topics: Aged; Anti-Arrhythmia Agents; Disopyramide; Electrocardiography; Female; Humans; Male; Middle Aged; | 1982 |
[Syncope associated with prolonged QT-interval on the electrocardiogram].
Topics: Adult; Aged; Disopyramide; Electrocardiography; Female; Heart Defects, Congenital; Humans; Syncope | 1981 |
Low dose disopyramide often fails to prevent neurogenic syncope during head-up tilt testing.
Topics: Adolescent; Adult; Aged; Blood Pressure; Disopyramide; Female; Head; Heart Rate; Humans; Isoproteren | 1994 |
Head-up tilt testing: the balance of evidence.
Topics: Adrenergic beta-Antagonists; Disopyramide; Humans; Posture; Syncope | 1995 |
Postpartum syncope.
Topics: 1-Naphthylamine; Administration, Oral; Adolescent; Adult; Diagnosis, Differential; Disopyramide; Dos | 1995 |
The relationship between neurally mediated hypotension and the chronic fatigue syndrome.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Di | 1995 |
Clinical presentation and long-term follow-up of athletes with exercise-induced vasodepressor syncope.
Topics: Adolescent; Adult; Age of Onset; Atenolol; Bradycardia; Disopyramide; Drug Combinations; Exercise; E | 1995 |
Is neurally mediated hypotension an unrecognised cause of chronic fatigue?
Topics: Adolescent; Atenolol; Autonomic Nervous System Diseases; Blood Pressure; Child; Disopyramide; Fatigu | 1995 |
Exercise induced vasodepressor syncope.
Topics: Adolescent; Adult; Aged; Cardiac Output; Disopyramide; Exercise; Exercise Test; Female; Heart Rate; | 1994 |
Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole.
Topics: Adolescent; Adult; Aged; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Female; Follow-Up St | 1993 |
The use of methylphenidate in the treatment of refractory neurocardiogenic syncope.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Bradycardia; Central Nervous S | 1996 |
[Iatrogenic collapse; can this be prevented?].
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Anti-Bacterial Agents; Disopyramide; Erythro | 1997 |
Clinical characteristics of patients with spontaneous or inducible ventricular fibrillation without apparent heart disease presenting with J wave and ST segment elevation in inferior leads.
Topics: Adult; Anti-Arrhythmia Agents; Cardiac Complexes, Premature; Defibrillators, Implantable; Disopyrami | 2000 |
Fatal overdosage with disopyramide.
Topics: Adolescent; Adult; Apnea; Disopyramide; Female; Heart Arrest; Humans; Male; Pulmonary Edema; Pyridin | 1978 |
Disopyramide-induced syncope.
Topics: Arrhythmias, Cardiac; Disopyramide; Female; Humans; Pyridines; Quinidine; Syncope | 1979 |
Clinical and electrophysiological observations with disopyramide in drug-resistant and recurrent symptomatic arrhythmias.
Topics: Adult; Aged; Arrhythmias, Cardiac; Depression, Chemical; Disopyramide; Drug Resistance; Electrophysi | 1978 |
[Letter: Syncopes through the inversion of points in connection with the absorption of disopyramide].
Topics: Arrhythmias, Cardiac; Coronary Disease; Disopyramide; Female; Humans; Hypertension; Hypokalemia; Mid | 1975 |
Recurrent unexplained syncope in the elderly: the use of head-upright tilt table testing in evaluation and management.
Topics: Aged; Aged, 80 and over; Atenolol; Beds; Blood Pressure; Disopyramide; Drug Therapy, Combination; El | 1992 |
Clinical features of sustained ventricular tachycardia among various underlying heart diseases.
Topics: Adult; Disopyramide; Electroencephalography; Heart Diseases; Heart Rate; Heart Ventricles; Hemodynam | 1990 |
Usefulness of disopyramide for prevention of upright tilt-induced hypotension-bradycardia.
Topics: Adult; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Electrocardiography; Female; Hemodynam | 1990 |
Pacemaker syndrome with AAI rate variable pacing: importance of atrioventricular conduction properties, medication, and pacemaker programmability.
Topics: Aged; Atrioventricular Node; Bradycardia; Disopyramide; Dizziness; Equipment Design; Exercise; Heart | 1988 |