disopyramide has been researched along with Disease Models, Animal in 17 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combined effects of disopyramide (DP) and erythromycin (EM) on ventricular repolarization and the inciden-ces of ventricular premature contractions (VPCs) and torsades de pointes (TdP) were investigated in 12 anesthetized dogs with complete atrioventricular block." | 7.77 | Combined effect of disopyramide and erythromycin on ventricular repolarization in dogs with complete atrioventricular block. ( Hirayama, A; Kasamaki, Y; Kofune, M; Mano, H; Nagashima, K; Ohkubo, K; Okumura, Y; Sonoda, K; Watanabe, I, 2011) |
| "Antiarrhythmic effects of bisaramil were examined by using new in vivo triggered arrhythmia models, and they were compared with those of other antiarrhythmic drugs." | 7.69 | Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. ( Haruno, A; Hashimoto, K, 1995) |
| "This study was performed to investigate the prophylactic effect of disopyramide phosphate on ventricular fibrillation in acute myocardial infarction." | 7.66 | Studies on the preventive method of lowered ventricular fibrillation threshold during experimental acute myocardial infarctions. A comparison between disopyramide phosphate and lidocaine. ( Fukuzaki, H; Hatani, M; Hori, Y; Imai, N; Nadai, T; Okamoto, R; Takano, S; Toh, H, 1981) |
| "The combined effects of disopyramide (DP) and erythromycin (EM) on ventricular repolarization and the inciden-ces of ventricular premature contractions (VPCs) and torsades de pointes (TdP) were investigated in 12 anesthetized dogs with complete atrioventricular block." | 3.77 | Combined effect of disopyramide and erythromycin on ventricular repolarization in dogs with complete atrioventricular block. ( Hirayama, A; Kasamaki, Y; Kofune, M; Mano, H; Nagashima, K; Ohkubo, K; Okumura, Y; Sonoda, K; Watanabe, I, 2011) |
| "Antiarrhythmic effects and cardiovascular effects of pilsicainide hydrochloride were compared with those of disopyramide in a canine model of coronary ligation-induced ventricular arrhythmias and anesthetized dogs." | 3.70 | [Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide]. ( Hayashi, Y; Hidaka, T; Inomata, N; Inoue, T; Komoriya, K, 2000) |
| "Antiarrhythmic effects of bisaramil were examined by using new in vivo triggered arrhythmia models, and they were compared with those of other antiarrhythmic drugs." | 3.69 | Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog. ( Haruno, A; Hashimoto, K, 1995) |
| "This study was performed to investigate the prophylactic effect of disopyramide phosphate on ventricular fibrillation in acute myocardial infarction." | 3.66 | Studies on the preventive method of lowered ventricular fibrillation threshold during experimental acute myocardial infarctions. A comparison between disopyramide phosphate and lidocaine. ( Fukuzaki, H; Hatani, M; Hori, Y; Imai, N; Nadai, T; Okamoto, R; Takano, S; Toh, H, 1981) |
| "Milrinone (M) has been shown to improve left ventricular (LV) performance in animal and human studies." | 1.27 | Evaluation of the vasodilator vs inotropic effect of milrinone using an animal model of left ventricular failure: reversal of disopyramide depression of the myocardium with milrinone. ( Berdoff, R; Goldberg, E; Haimowitz, A; Spivack, G; Tay, S, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 7 (41.18) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 1 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Chorvat, RJ | 1 |
| Prodan, KA | 1 |
| Adelstein, GW | 1 |
| Rydzewski, RM | 1 |
| McLaughlin, KT | 1 |
| Stamm, MH | 1 |
| Frederick, LG | 1 |
| Schniepp, HC | 1 |
| Stickney, JL | 1 |
| Johnson, RE | 1 |
| Baizman, ER | 1 |
| Becker, C | 1 |
| Bohnet, EA | 1 |
| Bell, RH | 1 |
| Birsner, NC | 1 |
| Busacca, CA | 1 |
| Carabateas, PM | 1 |
| Chadwick, CC | 1 |
| Gruett, MD | 1 |
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Król, M | 1 |
| Ufnal, M | 1 |
| Szulczyk, B | 1 |
| Podsadni, P | 1 |
| Drapała, A | 1 |
| Turło, J | 1 |
| Dawidowski, M | 1 |
| Watanabe, I | 1 |
| Okumura, Y | 1 |
| Nagashima, K | 1 |
| Kofune, M | 1 |
| Ohkubo, K | 1 |
| Mano, H | 1 |
| Sonoda, K | 1 |
| Kasamaki, Y | 1 |
| Hirayama, A | 1 |
| Yoshida, H | 1 |
| Sugiyama, A | 1 |
| Satoh, Y | 1 |
| Ishida, Y | 1 |
| Kugiyama, K | 1 |
| Hashimoto, K | 2 |
| Marshall, RJ | 1 |
| Muir, AW | 1 |
| Winslow, E | 1 |
| Hori, Y | 1 |
| Okamoto, R | 1 |
| Hatani, M | 1 |
| Imai, N | 1 |
| Toh, H | 1 |
| Takano, S | 1 |
| Nadai, T | 1 |
| Fukuzaki, H | 1 |
| Haruno, A | 1 |
| Komori, S | 1 |
| Sawanobori, T | 1 |
| Tamura, K | 1 |
| Kane, KA | 1 |
| Parratt, JR | 1 |
| Ogawa, S | 1 |
| Mitamura, H | 1 |
| Katoh, H | 1 |
| Imamura, H | 1 |
| Furukawa, Y | 1 |
| Kasama, M | 1 |
| Hoyano, Y | 1 |
| Yonezawa, T | 1 |
| Chiba, S | 1 |
| Matsunaga, T | 1 |
| Mitsui, T | 1 |
| Harada, T | 1 |
| Inokuma, M | 1 |
| Murano, H | 1 |
| Shibutani, Y | 1 |
| Hidaka, T | 1 |
| Inoue, T | 1 |
| Komoriya, K | 1 |
| Hayashi, Y | 1 |
| Inomata, N | 1 |
| Hashimoto, H | 1 |
| Satoh, N | 1 |
| Nakashima, M | 1 |
| Goldberg, E | 1 |
| Berdoff, R | 1 |
| Spivack, G | 1 |
| Haimowitz, A | 1 |
| Tay, S | 1 |
17 other studies available for disopyramide and Disease Models, Animal
| Article | Year |
|---|---|
Synthesis and structure-activity relationships of a new series of antiarrhythmic agents: 4,4-disubstituted hexahydro-3H-pyrido[1,2-c]pyrimidin-3-ones and related compounds.
Topics: Animals; Arrhythmias, Cardiac; Blood Pressure; Brain; Chemical Phenomena; Chemistry; Depression, Che | 1985 |
4,5-Dihydro-1-phenyl-1H-2,4-benzodiazepines: novel antiarrhythmic agents.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Benzodiazepines; Cats; Disease Models, Animal | 1993 |
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Characterization of Disopyramide derivative ADD424042 as a non-cardiotoxic neuronal sodium channel blocker with broad-spectrum anticonvulsant activity in rodent seizure models.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Disease Models, Animal; Disopyramide; Electrocardi | 2016 |
Combined effect of disopyramide and erythromycin on ventricular repolarization in dogs with complete atrioventricular block.
Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Atrioventricular Block; Disease Models, Animal; | 2011 |
Effects of disopyramide and mexiletine on the terminal repolarization process of the in situ heart assessed using the halothane-anesthetized in vivo canine model.
Topics: Action Potentials; Anesthetics, Inhalation; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac | 2002 |
Development of a severe model of early coronary artery ligation-induced dysrhythmias in the anaesthetized rat.
Topics: Androstanols; Angiotensin II; Animals; Arrhythmias, Cardiac; Atropine; Catecholamines; Coronary Vess | 1981 |
Studies on the preventive method of lowered ventricular fibrillation threshold during experimental acute myocardial infarctions. A comparison between disopyramide phosphate and lidocaine.
Topics: Animals; Disease Models, Animal; Disopyramide; Dogs; Dose-Response Relationship, Drug; Injections, I | 1981 |
Antiarrhythmic effects of bisaramil on triggered arrhythmias produced by intracoronary injection of digitalis and adrenaline in the dog.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Bridged Bicyclo Compounds, Heterocyclic; Chlo | 1995 |
Effects of NS-2, a new class 1 antiarrhythmic agent, and AFD-19, its active metabolite, on ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized rats: comparison with disopyramide and mexiletine.
Topics: Amino Alcohols; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Dise | 1994 |
Effect of E-4031, a new class III antiarrhythmic drug, on reentrant ventricular arrhythmias: comparison with conventional class I drugs.
Topics: Animals; Anti-Arrhythmia Agents; Aprindine; Arrhythmias, Cardiac; Disease Models, Animal; Disopyrami | 1993 |
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Respo | 1998 |
QT corrected for heart rate and relation between QT and RR intervals in beagle dogs.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Disopyramide; Dogs; Electrocardiography, Am | 1997 |
[Antiarrhythmic effects of pilsicainide hydrochloride and effects on cardiac function and ECG in dogs: comparison with disopyramide].
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disease Models, | 2000 |
Coupling interval-related effects of class I antiarrhythmic drugs, mexiletine, cibenzoline and disopyramide, on ventricular activation in canine myocardial infarction.
Topics: Animals; Anti-Arrhythmia Agents; Disease Models, Animal; Disopyramide; Dogs; Electric Stimulation; E | 1991 |
Evaluation of the vasodilator vs inotropic effect of milrinone using an animal model of left ventricular failure: reversal of disopyramide depression of the myocardium with milrinone.
Topics: Animals; Cardiac Output; Cardiotonic Agents; Depression, Chemical; Disease Models, Animal; Disopyram | 1987 |