disopyramide has been researched along with Bradycardia in 21 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
Bradycardia: Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study suggests that the patients showing bradycardia dependent QT prolongation are also more markedly affected by disopyramide and that abnormal potassium channel may be the underlying mechanism." | 7.70 | Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans. ( Abe, A; Aizawa, Y; Chinushi, M; Furushima, H; Niwano, S; Ohhira, K, 1998) |
| "Susceptibility to transient hypotension-bradycardia of neurally mediated origin has been attributed in part to accentuated afferent neural traffic arising from cardiopulmonary mechanoreceptors, and consequently, may be diminished by agents with anticholinergic and negative inotropic effects, such as disopyramide phosphate." | 7.68 | Usefulness of disopyramide for prevention of upright tilt-induced hypotension-bradycardia. ( Benditt, DG; Buetikofer, J; Dunnigan, A; Gornick, C; Milstein, S; Reyes, WJ, 1990) |
| "This study suggests that the patients showing bradycardia dependent QT prolongation are also more markedly affected by disopyramide and that abnormal potassium channel may be the underlying mechanism." | 3.70 | Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans. ( Abe, A; Aizawa, Y; Chinushi, M; Furushima, H; Niwano, S; Ohhira, K, 1998) |
| "Susceptibility to transient hypotension-bradycardia of neurally mediated origin has been attributed in part to accentuated afferent neural traffic arising from cardiopulmonary mechanoreceptors, and consequently, may be diminished by agents with anticholinergic and negative inotropic effects, such as disopyramide phosphate." | 3.68 | Usefulness of disopyramide for prevention of upright tilt-induced hypotension-bradycardia. ( Benditt, DG; Buetikofer, J; Dunnigan, A; Gornick, C; Milstein, S; Reyes, WJ, 1990) |
| "Disopyramide was given to 5 patients resulting in suppression of the arrhythmia and relief of symptoms." | 1.26 | Atrial bigeminy with block associated with bradycardia and paroxysmal atrial fibrillation -- an important variant of the tachycardia-bradycardia syndrome. ( Camm, AJ; Spurrell, RA; Ward, DE; Washington, HG, 1979) |
| " It is concluded that at therapeutic dosage disopyramide does not present deleterious hemodynamic effects in animals and proves to be a valid alternative to other traditional antiarrhythmic agents." | 1.26 | [Hemodynamic effects of disopyramide and procainamide in open-chest animals]. ( Binetti, G; Branzi, A; Magelli, C; Magnani, B; Malini, PL; Specchia, S; Zannoli, R, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (52.38) | 18.7374 |
| 1990's | 10 (47.62) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pedersen, C | 1 |
| Josephsen, P | 1 |
| Lindvig, K | 1 |
| Yamagishi, T | 1 |
| Ishii, K | 1 |
| Taira, N | 1 |
| Calkins, H | 1 |
| Seifert, M | 1 |
| Morady, F | 1 |
| Bergfeldt, L | 1 |
| Edvardsson, N | 1 |
| Rosenqvist, M | 1 |
| Vallin, H | 1 |
| Edhag, O | 1 |
| Sra, JS | 1 |
| Jazayeri, MR | 1 |
| Avitall, B | 1 |
| Dhala, A | 1 |
| Deshpande, S | 1 |
| Blanck, Z | 1 |
| Akhtar, M | 1 |
| Grubb, BP | 1 |
| Kosinski, D | 1 |
| Mouhaffel, A | 1 |
| Pothoulakis, A | 1 |
| Furushima, H | 1 |
| Niwano, S | 1 |
| Chinushi, M | 1 |
| Ohhira, K | 1 |
| Abe, A | 1 |
| Aizawa, Y | 1 |
| Imamura, H | 1 |
| Furukawa, Y | 1 |
| Kasama, M | 1 |
| Hoyano, Y | 1 |
| Yonezawa, T | 1 |
| Chiba, S | 1 |
| Washington, HG | 1 |
| Ward, DE | 1 |
| Camm, AJ | 1 |
| Spurrell, RA | 1 |
| Hayler, AM | 1 |
| Holt, DW | 1 |
| O'Keeffe, B | 1 |
| Medd, RK | 1 |
| Fox, K | 1 |
| Evans, T | 1 |
| Rowland, E | 1 |
| Krikler, D | 1 |
| Binetti, G | 1 |
| Branzi, A | 1 |
| Malini, PL | 1 |
| Specchia, S | 1 |
| Magelli, C | 1 |
| Zannoli, R | 1 |
| Magnani, B | 1 |
| LaBarre, A | 1 |
| Strauss, HC | 1 |
| Scheinman, MM | 1 |
| Evans, GT | 1 |
| Bashore, T | 1 |
| Tiedeman, JS | 1 |
| Wallace, AG | 1 |
| Barrillon, A | 1 |
| Grand, A | 1 |
| Pugh, DM | 1 |
| Seipel, L | 1 |
| Breithardt, G | 1 |
| Kasanuki, H | 1 |
| Ohnishi, S | 1 |
| Tamura, K | 1 |
| Nirei, T | 1 |
| Shoda, M | 1 |
| Hosoda, S | 1 |
| Brembilla-Perrot, B | 1 |
| Vaur, L | 1 |
| Milstein, S | 1 |
| Buetikofer, J | 1 |
| Dunnigan, A | 1 |
| Benditt, DG | 1 |
| Gornick, C | 1 |
| Reyes, WJ | 1 |
| den Dulk, K | 1 |
| Lindemans, FW | 1 |
| Brugada, P | 1 |
| Smeets, JL | 1 |
| Wellens, HJ | 1 |
| Lisin, N | 1 |
| Andriange, M | 1 |
| Vandenbosch, R | 1 |
| Carlier, J | 1 |
2 reviews available for disopyramide and Bradycardia
| Article | Year |
|---|---|
[Incompatibility and interference of the major cardiologic drugs. Their undesirable effects].
Topics: Anti-Arrhythmia Agents; Anti-Inflammatory Agents; Antihypertensive Agents; Bradycardia; Cardiac Glyc | 1976 |
[Efficacy and tolerance of disopyramide in arrhythmia associated with sinus node dysfunction].
Topics: Aged; Arrhythmias, Cardiac; Atropine; Bradycardia; Disopyramide; Electrocardiography, Ambulatory; El | 1991 |
1 trial available for disopyramide and Bradycardia
| Article | Year |
|---|---|
Clinical studies of Norpace (Part VI).
Topics: Adult; Anti-Arrhythmia Agents; Anticoagulants; Arrhythmias, Cardiac; Bradycardia; Clinical Trials as | 1975 |
18 other studies available for disopyramide and Bradycardia
| Article | Year |
|---|---|
[Interaction between disopyramide and pindolol after oral administration].
Topics: Administration, Oral; Aged; Bradycardia; Disopyramide; Drug Interactions; Female; Humans; Pindolol | 1983 |
Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Cloning, Molecular; Disopyramide; Dose-Response Relati | 1995 |
Clinical presentation and long-term follow-up of athletes with exercise-induced vasodepressor syncope.
Topics: Adolescent; Adult; Age of Onset; Atenolol; Bradycardia; Disopyramide; Drug Combinations; Exercise; E | 1995 |
Atrioventricular block progression in patients with bifascicular block assessed by repeated electrocardiography and a bradycardia-detecting pacemaker.
Topics: Aged; Aged, 80 and over; Bradycardia; Disopyramide; Electrocardiography; Electrophysiology; Female; | 1994 |
Comparison of cardiac pacing with drug therapy in the treatment of neurocardiogenic (vasovagal) syncope with bradycardia or asystole.
Topics: Adolescent; Adult; Aged; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Female; Follow-Up St | 1993 |
The use of methylphenidate in the treatment of refractory neurocardiogenic syncope.
Topics: Administration, Oral; Adolescent; Adrenergic beta-Antagonists; Adult; Bradycardia; Central Nervous S | 1996 |
Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Bradycardia; Cardiac Pacing, Artificial; Dis | 1998 |
Inhibition of delayed rectifier K+ current by dofetilide and E-4031 differentially affects electrical cardiac responses to vagus stimulation in anesthetized dogs.
Topics: Animals; Anti-Arrhythmia Agents; Bradycardia; Disease Models, Animal; Disopyramide; Dogs; Dose-Respo | 1998 |
Atrial bigeminy with block associated with bradycardia and paroxysmal atrial fibrillation -- an important variant of the tachycardia-bradycardia syndrome.
Topics: Adult; Aged; Atrial Fibrillation; Bradycardia; Cardiac Complexes, Premature; Disopyramide; Electroca | 1979 |
Treatment of disopyramide overdosage.
Topics: Antidotes; Bradycardia; Disopyramide; Humans; Isoproterenol; Pyridines; Seizures | 1979 |
'Bradycardia-tachycardia' syndrome 8 yr after correction of Fallot's tetralogy.
Topics: Adolescent; Arrhythmias, Cardiac; Atrial Flutter; Bradycardia; Child; Child, Preschool; Death, Sudde | 1979 |
[Hemodynamic effects of disopyramide and procainamide in open-chest animals].
Topics: Animals; Bradycardia; Disopyramide; Heart Rate; Hemodynamics; Procainamide; Pyridines; Sinoatrial No | 1978 |
Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular Node; Bradycardia; Cardiac | 1979 |
Letter: Sinus recovery time after disopyramide phosphate.
Topics: Bradycardia; Disopyramide; Humans; Pyridines | 1976 |
Acquired long QT syndrome due to antiarrhythmic drugs and bradyarrhythmias.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Bradycardia; Disopyramide; Electrocardiograp | 1992 |
Usefulness of disopyramide for prevention of upright tilt-induced hypotension-bradycardia.
Topics: Adult; Bradycardia; Cardiac Pacing, Artificial; Disopyramide; Electrocardiography; Female; Hemodynam | 1990 |
Pacemaker syndrome with AAI rate variable pacing: importance of atrioventricular conduction properties, medication, and pacemaker programmability.
Topics: Aged; Atrioventricular Node; Bradycardia; Disopyramide; Dizziness; Equipment Design; Exercise; Heart | 1988 |
[Treatment of disturbances of cardiac rhythm using intravenous disopyramide].
Topics: Adult; Aged; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Brad | 1974 |