disopyramide has been researched along with Acute Liver Injury, Drug-Induced in 9 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Postmarketing drug surveillance revealed the occurrence of hypoglycemia associated with the use of disopyramide phosphate (Norpace) for the control of ventricular arrhythmias." | 9.05 | Hypoglycemia in patients receiving disopyramide phosphate. ( Cohen, A; Nitzberg, DM; Schubert, EN; Strathman, I, 1983) |
| " This case report shows that disopyramide can have the serious side effect of hepatocellular toxicity and provides evidence of the association of hepatocellular damage and disseminated intravascular coagulation." | 5.26 | Disopyramide hepatotoxicity and disseminated intravascular coagulation. ( Doody, PT, 1982) |
| "Postmarketing drug surveillance revealed the occurrence of hypoglycemia associated with the use of disopyramide phosphate (Norpace) for the control of ventricular arrhythmias." | 5.05 | Hypoglycemia in patients receiving disopyramide phosphate. ( Cohen, A; Nitzberg, DM; Schubert, EN; Strathman, I, 1983) |
| " This case report shows that disopyramide can have the serious side effect of hepatocellular toxicity and provides evidence of the association of hepatocellular damage and disseminated intravascular coagulation." | 1.26 | Disopyramide hepatotoxicity and disseminated intravascular coagulation. ( Doody, PT, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Strathman, I | 1 |
| Schubert, EN | 1 |
| Cohen, A | 1 |
| Nitzberg, DM | 1 |
| Antonelli, D | 1 |
| Koltun, B | 1 |
| Barzilay, J | 1 |
| Bakris, GL | 1 |
| Cross, PD | 1 |
| Hammarsten, JE | 1 |
| Doody, PT | 1 |
1 review available for disopyramide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
1 trial available for disopyramide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Hypoglycemia in patients receiving disopyramide phosphate.
Topics: Aged; Blood Glucose; Chemical and Drug Induced Liver Injury; Clinical Trials as Topic; Disopyramide; | 1983 |
7 other studies available for disopyramide and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Acute hepatotoxic effect of disopyramide.
Topics: Atrial Fibrillation; Chemical and Drug Induced Liver Injury; Disopyramide; Female; Humans; Middle Ag | 1984 |
Disopyramide-associated liver dysfunction.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cholestasis; Disopyramide; Humans; Male; Middle | 1983 |
Disopyramide hepatotoxicity and disseminated intravascular coagulation.
Topics: Chemical and Drug Induced Liver Injury; Disopyramide; Disseminated Intravascular Coagulation; Female | 1982 |