disopyramide has been researched along with A-V Dissociation in 31 studies
Disopyramide: A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
disopyramide : A monocarboxylic acid amide that is butanamide substituted by a diisopropylamino group at position 4, a phenyl group at position 2 and a pyridin-2-yl group at position 2. It is used as a anti-arrhythmia drug.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral disopyramide given prophylactically following myocardial infarction has been compared with placebo in a double-blind trial using continuous-tape monoriting of the electocardiogram." | 9.04 | Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction. ( Besterman, EM; Jennings, G; Jones, MS; Kidner, PH; Model, DG; Turner, PP, 1976) |
| "Patients with acute myocardial infarction admitted to open wards of three hospitals were given either oral disopyramide (100 mg four times daily) or matching placebo, prophylactically, for seven days." | 9.04 | Oral disopyramide for the prevention of arrhythmias in patients with acute myocardial infarction admitted to open wards. ( Besterman, EM; Carmichael, DJ; Gillham, AD; Griffiths, JW; Kidner, PH; Summers, GD; Zainal, N, 1977) |
| "This study suggests that the patients showing bradycardia dependent QT prolongation are also more markedly affected by disopyramide and that abnormal potassium channel may be the underlying mechanism." | 7.70 | Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans. ( Abe, A; Aizawa, Y; Chinushi, M; Furushima, H; Niwano, S; Ohhira, K, 1998) |
| "Three cases are described with documented ventricular fibrillation shortly after the patients received disopyramide in moderate dosage." | 7.66 | Disopyramide-induced ventricular fibrillation. ( Gracey, JG; Knoch, HR; Martin, CE; Nicholson, WJ, 1979) |
| "Out of the 28 severe arrhythmias studied, it was the ventricular extrasystoles which benefited most from treatment (79% completely successful, while there was a lesser degree of success in treating the ventricular tachycardias (35% completely successful, 30% partially successful)." | 6.64 | [Action of injected disopyramide on ventricular arrhythmias and atrioventricular conduction]. ( Bellanger, P; Desoutter, P; Motté, G; Vogel, M; Welti, JJ, 1976) |
| "The arrhythmia started with an atrial extrasystole arising well outside the functional refractory period of the AV node, and it could be reproduced by inflation of a balloon." | 5.26 | Ectopic atrial tachycardia on swallowing. Report on favourable effect of verapamil. ( Landmark, K; Storstein, O, 1979) |
| "Oral disopyramide given prophylactically following myocardial infarction has been compared with placebo in a double-blind trial using continuous-tape monoriting of the electocardiogram." | 5.04 | Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction. ( Besterman, EM; Jennings, G; Jones, MS; Kidner, PH; Model, DG; Turner, PP, 1976) |
| "Patients with acute myocardial infarction admitted to open wards of three hospitals were given either oral disopyramide (100 mg four times daily) or matching placebo, prophylactically, for seven days." | 5.04 | Oral disopyramide for the prevention of arrhythmias in patients with acute myocardial infarction admitted to open wards. ( Besterman, EM; Carmichael, DJ; Gillham, AD; Griffiths, JW; Kidner, PH; Summers, GD; Zainal, N, 1977) |
| "Since disopyramide was introduced 5 years ago, the therapeutic spectrum of this drug in treating patients with ventricular and atrial arrhythmias has been found to be similar to that of the other type I antiarrhythmic drugs, quinidine and procainamide." | 4.76 | Disopyramide. ( Desai, J; Morady, F; Scheinman, MM, 1982) |
| "This study suggests that the patients showing bradycardia dependent QT prolongation are also more markedly affected by disopyramide and that abnormal potassium channel may be the underlying mechanism." | 3.70 | Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans. ( Abe, A; Aizawa, Y; Chinushi, M; Furushima, H; Niwano, S; Ohhira, K, 1998) |
| "Three hundred fifty-eight of 429 (83%) consecutive patients with acute myocardial infarction (MI) and a normal PR interval received various antiarrhythmic drugs (AD), including lidocaine and/or procainamide, quinidine, digoxin, propranolol or disopyramide." | 3.66 | Effects of antiarrhythmic drugs on atrioventricular conduction in patients with acute myocardial infarction. ( Abbott, JA; Cheitlin, MD; Desai, J; Holford, N; Peters, RW; Remedios, P; Scheinman, MM, 1980) |
| "Three cases are described with documented ventricular fibrillation shortly after the patients received disopyramide in moderate dosage." | 3.66 | Disopyramide-induced ventricular fibrillation. ( Gracey, JG; Knoch, HR; Martin, CE; Nicholson, WJ, 1979) |
| "Out of the 28 severe arrhythmias studied, it was the ventricular extrasystoles which benefited most from treatment (79% completely successful, while there was a lesser degree of success in treating the ventricular tachycardias (35% completely successful, 30% partially successful)." | 2.64 | [Action of injected disopyramide on ventricular arrhythmias and atrioventricular conduction]. ( Bellanger, P; Desoutter, P; Motté, G; Vogel, M; Welti, JJ, 1976) |
| "Syncopal attacks in patients with bifascicular block may be due to both ventricular tachyarrhythmias and intermittent atrioventricular block in addition to non-cardiac causes and lead to antiarrhythmic treatment with drugs or pacemaker or both." | 1.27 | Disopyramide induced second and third degree atrioventricular block in patients with bifascicular block. An acute stress test to predict atrioventricular block progression. ( Bergfeldt, L; Edhag, O; Rosenqvist, M; Vallin, H, 1985) |
| "A 57-year-old woman with right bundle branch block +LPH and ventricular premature contractions developed complete heart block (CHB) following administration of disopyramide phosphate (Norpace)." | 1.26 | Disopyramide-induced heart block. ( Gutman, JA; Haft, JI; Timins, BI, 1981) |
| "The arrhythmia started with an atrial extrasystole arising well outside the functional refractory period of the AV node, and it could be reproduced by inflation of a balloon." | 1.26 | Ectopic atrial tachycardia on swallowing. Report on favourable effect of verapamil. ( Landmark, K; Storstein, O, 1979) |
| "Disopyramide was given to 5 patients resulting in suppression of the arrhythmia and relief of symptoms." | 1.26 | Atrial bigeminy with block associated with bradycardia and paroxysmal atrial fibrillation -- an important variant of the tachycardia-bradycardia syndrome. ( Camm, AJ; Spurrell, RA; Ward, DE; Washington, HG, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (87.10) | 18.7374 |
| 1990's | 4 (12.90) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamaguchi, A | 1 |
| Kato, T | 1 |
| Shimada, E | 1 |
| Matsumoto, K | 1 |
| Asano, H | 1 |
| Yamane, Y | 1 |
| Watanabe, M | 1 |
| Jackman, WM | 1 |
| Friday, KJ | 1 |
| Scherlag, BJ | 1 |
| Dehning, MM | 1 |
| Schechter, E | 1 |
| Reynolds, DW | 1 |
| Olson, EG | 1 |
| Berbari, EJ | 1 |
| Harrison, LA | 1 |
| Lazzara, R | 1 |
| Morady, F | 1 |
| Scheinman, MM | 4 |
| Desai, J | 3 |
| Timins, BI | 2 |
| Wilkinson, PR | 1 |
| Hollister, J | 1 |
| Gonzalez, R | 1 |
| Abbott, JA | 2 |
| Gutman, JA | 1 |
| Haft, JI | 1 |
| Kannelønning, KS | 1 |
| Tonkin, AM | 1 |
| Joel, SE | 1 |
| Reynolds, JL | 1 |
| Remedios, P | 1 |
| Cheitlin, MD | 1 |
| Peters, RW | 1 |
| Holford, N | 1 |
| Rothman, MT | 1 |
| Bergfeldt, L | 3 |
| Edvardsson, N | 1 |
| Rosenqvist, M | 3 |
| Vallin, H | 2 |
| Edhag, O | 2 |
| Englund, A | 1 |
| Furushima, H | 1 |
| Niwano, S | 1 |
| Chinushi, M | 1 |
| Ohhira, K | 1 |
| Abe, A | 1 |
| Aizawa, Y | 2 |
| Debbas, NM | 1 |
| Jackson, SH | 1 |
| de Jonghe, D | 1 |
| Robert, A | 1 |
| Camm, AJ | 3 |
| Jennings, G | 1 |
| Jones, MS | 1 |
| Besterman, EM | 2 |
| Model, DG | 1 |
| Turner, PP | 1 |
| Kidner, PH | 2 |
| Vogel, M | 1 |
| Desoutter, P | 1 |
| Bellanger, P | 1 |
| Motté, G | 1 |
| Welti, JJ | 1 |
| Zainal, N | 1 |
| Carmichael, DJ | 1 |
| Griffiths, JW | 1 |
| Gillham, AD | 1 |
| Summers, GD | 1 |
| Ross, D | 2 |
| Vohra, J | 2 |
| Sloman, JG | 1 |
| Landmark, K | 1 |
| Storstein, O | 1 |
| Washington, HG | 1 |
| Ward, DE | 1 |
| Spurrell, RA | 1 |
| Cole, P | 1 |
| Hunt, D | 1 |
| Sloman, G | 1 |
| Nicholson, WJ | 1 |
| Martin, CE | 1 |
| Gracey, JG | 1 |
| Knoch, HR | 1 |
| LaBarre, A | 1 |
| Strauss, HC | 1 |
| Evans, GT | 1 |
| Bashore, T | 1 |
| Tiedeman, JS | 1 |
| Wallace, AG | 1 |
| Danilo, P | 1 |
| Rosen, MR | 1 |
| Fowler, NO | 1 |
| Befeler, B | 1 |
| Funazaki, T | 1 |
| Satoh, M | 1 |
| Suzuki, K | 1 |
| Aizawa, M | 1 |
| Shibata, A | 1 |
| Lau, CP | 1 |
| Griffith, MJ | 1 |
| Junien, JL | 1 |
| Lakatos, CR | 1 |
| Tine, J | 1 |
| Duchêne-Marullaz, P | 1 |
| Lapalus, P | 1 |
| Lavarenne, J | 1 |
| Combre, A | 1 |
2 reviews available for disopyramide and A-V Dissociation
| Article | Year |
|---|---|
Disopyramide.
Topics: Arrhythmias, Cardiac; Disopyramide; Drug Interactions; Electrophysiology; Heart; Heart Block; Humans | 1982 |
Cardiac effects of disopyramide.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrioventricular Node; Clinical Trials as Topic; D | 1976 |
5 trials available for disopyramide and A-V Dissociation
| Article | Year |
|---|---|
Oral disopyramide in prophylaxis of arrhythmias following myocardial infarction.
Topics: Administration, Oral; Arrhythmias, Cardiac; Atrial Fibrillation; Clinical Trials as Topic; Disopyram | 1976 |
[Action of injected disopyramide on ventricular arrhythmias and atrioventricular conduction].
Topics: Aged; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Clinical Trials as Topic; Disopyramide; Dr | 1976 |
Oral disopyramide for the prevention of arrhythmias in patients with acute myocardial infarction admitted to open wards.
Topics: Acute Disease; Administration, Oral; Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Disopyram | 1977 |
Cardiac effects of disopyramide.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Atrioventricular Node; Clinical Trials as Topic; D | 1976 |
Clinical studies of Norpace. Summarizing remarks.
Topics: Administration, Oral; Adult; Aged; Ambulatory Care; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; At | 1975 |
25 other studies available for disopyramide and A-V Dissociation
| Article | Year |
|---|---|
[A case of atypical ventricular tachycardia induced by disopyramide].
Topics: Disopyramide; Heart Block; Humans; Male; Tachycardia | 1984 |
Direct endocardial recording from an accessory atrioventricular pathway: localization of the site of block, effect of antiarrhythmic drugs, and attempt at nonsurgical ablation.
Topics: Adult; Anti-Arrhythmia Agents; Atrioventricular Node; Cardiac Pacing, Artificial; Disopyramide; Ebst | 1983 |
Disopyramide and bundle-branch block.
Topics: Bundle-Branch Block; Disopyramide; Female; Heart Block; Humans; Middle Aged; Pyridines | 1982 |
Electrophysiologic effects of disopyramide in patients with atrioventricular nodal dysfunction.
Topics: Aged; Anti-Arrhythmia Agents; Cardiac Pacing, Artificial; Disopyramide; Electrocardiography; Electro | 1982 |
Disopyramide-induced heart block.
Topics: Bundle-Branch Block; Disopyramide; Female; Heart Block; Heart Conduction System; Humans; Middle Aged | 1981 |
[Cardiac shock after disopyramide].
Topics: Disopyramide; Heart Block; Heart Failure; Humans; Male; Middle Aged; Pyridines; Shock, Cardiogenic | 1981 |
Unusual hepatocellular and cardiovascular complications of disopyramide.
Topics: Aged; Cardiovascular System; Disopyramide; Heart Block; Humans; Hypertension; Liver; Male; Middle Ag | 1980 |
Effects of antiarrhythmic drugs on atrioventricular conduction in patients with acute myocardial infarction.
Topics: Aged; Anti-Arrhythmia Agents; Bundle-Branch Block; Digoxin; Disopyramide; Heart Block; Heart Conduct | 1980 |
Prolonged QT interval, atrioventricular block, and torsade de pointes after antiarrhythmic therapy.
Topics: Aged; Disopyramide; Electrocardiography; Female; Heart; Heart Block; Humans; Lidocaine; Pyridines; T | 1980 |
Atrioventricular block progression in patients with bifascicular block assessed by repeated electrocardiography and a bradycardia-detecting pacemaker.
Topics: Aged; Aged, 80 and over; Bradycardia; Disopyramide; Electrocardiography; Electrophysiology; Female; | 1994 |
Disopyramide stress test: a sensitive and specific tool for predicting impending high degree atrioventricular block in patients with bifascicular block.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Disopyramide; Electrocardiography; Electrophysiology; Fe | 1995 |
Relation between bradycardia dependent long QT syndrome and QT prolongation by disopyramide in humans.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Bradycardia; Cardiac Pacing, Artificial; Dis | 1998 |
Human atrial repolarization: effects of sinus rate, pacing and drugs on the surface electrocardiogram.
Topics: Adult; Aged; Aged, 80 and over; Anti-Arrhythmia Agents; Atropine; Cardiac Pacing, Artificial; Disopy | 1999 |
Disopyramide in myocardial infarction.
Topics: Depression, Chemical; Disopyramide; Heart Block; Heart Conduction System; Humans; Hypotension; Myoca | 1978 |
Ectopic atrial tachycardia on swallowing. Report on favourable effect of verapamil.
Topics: Atrioventricular Node; Atropine; Cardiac Complexes, Premature; Deglutition; Disopyramide; Edrophoniu | 1979 |
Atrial bigeminy with block associated with bradycardia and paroxysmal atrial fibrillation -- an important variant of the tachycardia-bradycardia syndrome.
Topics: Adult; Aged; Atrial Fibrillation; Bradycardia; Cardiac Complexes, Premature; Disopyramide; Electroca | 1979 |
Electrophysiology of disopyramide in man.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atrioventricular Node; Disopyramide; Electrocardiogra | 1978 |
Disopyramide-induced ventricular fibrillation.
Topics: Administration, Oral; Aged; Arrhythmias, Cardiac; Disopyramide; Electrocardiography; Female; Heart B | 1979 |
Electrophysiologic effects of disopyramide phosphate on sinus node function in patients with sinus node dysfunction.
Topics: Adult; Aged; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular Node; Bradycardia; Cardiac | 1979 |
The electrophysiology of Norpace (Part II).
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventricular Node; Disopyramide; Drug Evaluation; | 1975 |
Periodic changes in cycle length of ventricular tachycardia: a Wenckebach type exit block?
Topics: Bundle of His; Cardiac Complexes, Premature; Cardiac Pacing, Artificial; Disopyramide; Electrocardio | 1986 |
Ventricular Wenckebach after intravenous therapy with class I antiarrhythmic agents.
Topics: Adult; Cardiac Pacing, Artificial; Disopyramide; Electrophysiology; Female; Flecainide; Heart Block; | 1988 |
Disopyramide induced second and third degree atrioventricular block in patients with bifascicular block. An acute stress test to predict atrioventricular block progression.
Topics: Adult; Aged; Bundle-Branch Block; Disopyramide; Electrocardiography; Female; Follow-Up Studies; Hear | 1985 |
Comparative effect of imolamine, lidocaine and disopyramide on experimental rhythm disorders and auriculoventricular conduction.
Topics: Aconitum; Animals; Anti-Arrhythmia Agents; Blood Pressure; Cardiac Complexes, Premature; Diethylamin | 1974 |
[Comparison of the effects of quinidine, diphenylhydantoin and disopyramide on the auricular refractory period in the anesthetized dog].
Topics: Animals; Atrial Function; Disopyramide; Dogs; Electric Stimulation; Female; Heart Atria; Heart Block | 1974 |