discodermolide and Colorectal-Neoplasms

discodermolide has been researched along with Colorectal-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for discodermolide and Colorectal-Neoplasms

Article	Year
Discodermolide analogues as the chemical component of combination bacteriolytic therapy. Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15 The marine natural product (+)-discodermolide (1) and several simplified analogues of this microtubule-stabilizing agent have proven to be potent in vitro cell growth inhibitory agents in several human cancer cell lines. Here, we demonstrate the in vivo efficacy of discodermolide and several simplified congeners, both as stand-alone anti-tumor agents and, in the case of (+)-2,3-anhydrodiscodermolide (3), as a chemical component of the combination bacteriolytic therapy. A single intravenous injection of (+)-3 plus genetically modified Clostridium novyi-NT spores caused rapid and complete regressions of tumors in mice bearing HCT116 colorectal cancer xenografts. Topics: Alkanes; Animals; Antineoplastic Agents; Bacterial Toxins; Binding Sites; Carbamates; Colorectal Neoplasms; Combined Modality Therapy; Injections, Intravenous; Lactones; Mice; Microtubules; Molecular Structure; Pyrones; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured	2005

Article

Year

Discodermolide analogues as the chemical component of combination bacteriolytic therapy.

Bioorganic & medicinal chemistry letters, 2005, Aug-01, Volume: 15, Issue:15

The marine natural product (+)-discodermolide (1) and several simplified analogues of this microtubule-stabilizing agent have proven to be potent in vitro cell growth inhibitory agents in several human cancer cell lines. Here, we demonstrate the in vivo efficacy of discodermolide and several simplified congeners, both as stand-alone anti-tumor agents and, in the case of (+)-2,3-anhydrodiscodermolide (3), as a chemical component of the combination bacteriolytic therapy. A single intravenous injection of (+)-3 plus genetically modified Clostridium novyi-NT spores caused rapid and complete regressions of tumors in mice bearing HCT116 colorectal cancer xenografts.

Topics: Alkanes; Animals; Antineoplastic Agents; Bacterial Toxins; Binding Sites; Carbamates; Colorectal Neoplasms; Combined Modality Therapy; Injections, Intravenous; Lactones; Mice; Microtubules; Molecular Structure; Pyrones; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured

2005