Analytical chemistry, 2020, 09-15, Volume: 92, Issue:18
Senescence-associated diseases have severely diminished the quality of life and health of patients. However, a sensitive assay of these diseases remains limited due to a lack of straightforward methods. Considering that senescence-associated β-galactosidase (SA-β-Gal) is overexpressed in senescent cells, the detection of SA-β-Gal in senescent cells and tissues might be a feasible strategy for the early diagnosis of SA diseases. In this study, a β-galactosidase-activatable nanoprobe Topics: Animals; Atherosclerosis; beta-Galactosidase; Boron; Cellular Senescence; Fluorescent Dyes; Male; Mice; Mice, Inbred C57BL; Molecular Structure; Nanoparticles; Porphobilinogen; Rats; Rats, Sprague-Dawley | 2020 |