Page last updated: 2024-10-26

dipyridamole and Osteosarcoma

dipyridamole has been researched along with Osteosarcoma in 4 studies

Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Osteosarcoma: A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)

Research Excerpts

ExcerptRelevanceReference
"To test a novel strategy for overcoming intrinsic resistance to methotrexate (MTX) in osteosarcoma (OS) due to nucleoside and nucleobase salvage (NS)."7.71Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs. ( Cole, PD; Kamen, BA; Smith, AK, 2002)
"To test a novel strategy for overcoming intrinsic resistance to methotrexate (MTX) in osteosarcoma (OS) due to nucleoside and nucleobase salvage (NS)."3.71Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs. ( Cole, PD; Kamen, BA; Smith, AK, 2002)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19901 (25.00)18.7374
1990's0 (0.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Vlachodimou, A1
IJzerman, AP1
Heitman, LH1
Cole, PD1
Smith, AK1
Kamen, BA1
Goda, AE1
Yoshida, T1
Horinaka, M1
Yasuda, T1
Shiraishi, T1
Wakada, M1
Sakai, T1
Nelson, JA1
Drake, S1

Other Studies

4 other studies available for dipyridamole and Osteosarcoma

ArticleYear
Label-free detection of transporter activity via GPCR signalling in living cells: A case for SLC29A1, the equilibrative nucleoside transporter 1.
    Scientific reports, 2019, 09-24, Volume: 9, Issue:1

    Topics: Cell Line, Tumor; Equilibrative Nucleoside Transporter 1; Humans; Ligands; Membrane Transport Protei

2019
Osteosarcoma cells, resistant to methotrexate due to nucleoside and nucleobase salvage, are sensitive to nucleoside analogs.
    Cancer chemotherapy and pharmacology, 2002, Volume: 50, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Bone Neoplasms; Cattle; Culture Medi

2002
Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole.
    Oncogene, 2008, May-29, Volume: 27, Issue:24

    Topics: Apoptosis; Blotting, Northern; Bone Neoplasms; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinas

2008
Potentiation of methotrexate toxicity by dipyridamole.
    Cancer research, 1984, Volume: 44, Issue:6

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line; Cell Survival; Cricetinae; Crice

1984