Page last updated: 2024-10-26

dipyridamole and Neuroblastoma

dipyridamole has been researched along with Neuroblastoma in 8 studies

Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"Following earlier observations that increasing the polyunsaturated fatty-acid (PUFA) content of N1E-115 neuroblastoma cells elevated basal and adenosine (Ado)-stimulated intracellular cyclic AMP (cAMP) formation, we carried out studies to determine the mechanism(s) by which PUFA exerted their modulatory effects."3.68Further studies of the mechanism(s) of polyunsaturated-fatty-acid-mediated increases in intracellular cAMP formation in N1E-115 neuroblastoma cells. ( Byczko, Z; Murphy, MG, 1992)
"5."1.32Extracellular metabolism of nucleotides in neuroblastoma x glioma NG108-15 cells determined by capillary electrophoresis. ( Kaulich, M; Müller, CE; Qurishi, R, 2003)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's2 (25.00)18.2507
2000's4 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Garcia-Gil, M1
Pesi, R1
Perna, S1
Allegrini, S1
Giannecchini, M1
Camici, M1
Tozzi, MG1
Kaulich, M1
Qurishi, R1
Müller, CE1
Messina, E1
Lupi, F1
Barile, L1
Giacomello, A1
Billington, RA1
Bellomo, EA1
Floriddia, EM1
Erriquez, J1
Distasi, C1
Genazzani, AA1
Green, RD2
Stanberry, LR1
Murphy, MG1
Byczko, Z1
Tebbi, CK1
Chervinsky, D1
Baker, RM1

Other Studies

8 other studies available for dipyridamole and Neuroblastoma

ArticleYear
5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.
    Neuroscience, 2003, Volume: 117, Issue:4

    Topics: 5'-Nucleotidase; Acetylcholine; Aminoimidazole Carboxamide; Apoptosis; Brain; Caspase 3; Caspases; C

2003
Extracellular metabolism of nucleotides in neuroblastoma x glioma NG108-15 cells determined by capillary electrophoresis.
    Cellular and molecular neurobiology, 2003, Volume: 23, Issue:3

    Topics: Adenosine; Alkaline Phosphatase; Animals; Chromatography, Micellar Electrokinetic Capillary; Dipyrid

2003
Cyclic nucleotides and neuroblastoma differentiation.
    Nucleosides, nucleotides & nucleic acids, 2004, Volume: 23, Issue:8-9

    Topics: Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cyclic AMP; Cyclic GMP; Dipyridamole; Do

2004
A transport mechanism for NAADP in a rat basophilic cell line.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2006, Volume: 20, Issue:3

    Topics: Animals; Autocrine Communication; Basophils; Biological Transport; Calcium; Calcium Signaling; Cell

2006
Effects of exogenous adenosine deaminase and erythro-9-(2-hydroxy-3-nonyl) adenine on intracellular cyclic AMP levels in C1300 murine neuroblastoma in tissue culture.
    Life sciences, 1980, Feb-04, Volume: 26, Issue:5

    Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Cell Line; Culture Techniques; Cyclic AMP; Dipyrid

1980
Elevation of cyclic AMP in C-1300 murine neuroblastoma by adenosine and related compounds and the antagonism of this response by methylxanthines.
    Biochemical pharmacology, 1977, Jan-01, Volume: 26, Issue:1

    Topics: Adenosine; Animals; Cell Line; Cyclic AMP; Dipyridamole; Mice; Neoplasms, Experimental; Neuroblastom

1977
Further studies of the mechanism(s) of polyunsaturated-fatty-acid-mediated increases in intracellular cAMP formation in N1E-115 neuroblastoma cells.
    Neurochemical research, 1992, Volume: 17, Issue:11

    Topics: 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone; 5'-Nucleotidase; Adenosine; Basal Metabolism; Colfor

1992
Modulation of drug resistance in homoharringtonine-resistant C-1300 neuroblastoma cells with cyclosporine A and dipyridamole.
    Journal of cellular physiology, 1991, Volume: 148, Issue:3

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter,

1991