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dipyridamole and Neoplasm Metastasis

dipyridamole has been researched along with Neoplasm Metastasis in 22 studies

Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Research Excerpts

ExcerptRelevanceReference
"Based upon the hypothesis that dipyridamole would potentiate the cytotoxicity of mitoxantrone and the combination of 5-fluorouracil (5-FU) and leukovorin, we performed a phase I/II trial of the combination of dipyridamole, 5-FU, leukovorin, and mitoxantrone in patients with metastatic breast cancer."9.07Phase I/II trial of dipyridamole, 5-fluorouracil, leukovorin, and mitoxantrone in metastatic breast cancer. ( Budd, GT; Bukowski, RM; Herzog, P, 1994)
"In an attempt to increase the clinical activity of 5-fluorouracil (5-FU) by blocking the thymidine salvage pathway, 15 patients with refractory metastatic breast cancer (MBC) were treated with oral dipyridamole (D): 75 mg p."7.675-Fluorouracil and dipyridamole in metastatic breast cancer: a pilot study. ( Marini, G; Marpicati, P; Montini, E; Palazzi, M; Pipino, G; Simoncini, E; Zaniboni, A, 1989)
"Mitomycin C was given to 9 patients as a third-line regimen with resulting 5 NC for 2-4 months."5.27[Sequential treatment of progressive metastatic colorectal cancer with 5-fluorouracil/folinic acid, dipyramidole and mitomycin C]. ( Farroukh, R; Gerlach, D; Hoffmann, W; Kress, M; Migeod, F; Seeber, S, 1988)
"Based upon the hypothesis that dipyridamole would potentiate the cytotoxicity of mitoxantrone and the combination of 5-fluorouracil (5-FU) and leukovorin, we performed a phase I/II trial of the combination of dipyridamole, 5-FU, leukovorin, and mitoxantrone in patients with metastatic breast cancer."5.07Phase I/II trial of dipyridamole, 5-fluorouracil, leukovorin, and mitoxantrone in metastatic breast cancer. ( Budd, GT; Bukowski, RM; Herzog, P, 1994)
"Our clinical study to prevent relapse and metastases in several sarcomas and malignant lymphomas of the head and neck region with a long-term treatment with mopidamole was initiated in 1972 because the pyrimido-pyrimidine derivative was shown to inhibit platelet aggregation in vivo and to increase significantly the circulation time of intravenously injected, 32P-labelled Ehrlich ascites tumour cells in mouse blood."4.76[Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results]. ( Gastpar, H, 1983)
" Previously, we showed that dual liposomes simultaneously containing the hemostatic inhibitor, dipyridamole and the anticancer drug, perifosine potently inhibited metastasis, causing a 90% reduction in the number of lung metastases in a murine experimental metastasis model."3.76Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation. ( Fichtner, I; Habedank, S; Haider, W; Wenzel, J; Zeisig, R, 2010)
"In an attempt to increase the clinical activity of 5-fluorouracil (5-FU) by blocking the thymidine salvage pathway, 15 patients with refractory metastatic breast cancer (MBC) were treated with oral dipyridamole (D): 75 mg p."3.675-Fluorouracil and dipyridamole in metastatic breast cancer: a pilot study. ( Marini, G; Marpicati, P; Montini, E; Palazzi, M; Pipino, G; Simoncini, E; Zaniboni, A, 1989)
"In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline)."3.67Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. ( Grimová, J; Kacerovská, H; Mamytbeková, A; Rezábek, K; Svobodová, J, 1986)
"Formation of lung and extrapulmonary metastases after intravenous administration of MT3 breast cancer cells was significantly reduced when mice were treated with a single intravenous dose of DIP/OPP-L containing 100nmol lipid 6h before tumour cell inoculation."1.35Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation. ( Fichtner, I; Wenzel, J; Zeisig, R, 2009)
"Out of 59 metastatic breast cancer cases analyzed, 22 (37%) were found to overexpress h-prune, evidence that this novel enzymatic activity is involved in promoting cancer metastasis."1.32Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. ( Aglio, V; André, A; Aravind, L; Arrigoni, G; Carotenuto, P; Cossu, A; D'Angelo, A; Garzia, L; Guardiola, O; Palmieri, G; Zollo, M, 2004)
"Mitomycin C was given to 9 patients as a third-line regimen with resulting 5 NC for 2-4 months."1.27[Sequential treatment of progressive metastatic colorectal cancer with 5-fluorouracil/folinic acid, dipyramidole and mitomycin C]. ( Farroukh, R; Gerlach, D; Hoffmann, W; Kress, M; Migeod, F; Seeber, S, 1988)
"The mechanism of the early stage of metastasis formation by sticky blood-born cancer cells is discussed."1.26Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis. ( Gastpar, H, 1977)
"A case of male breast carcinoma is discussed with reference to the effect of steroids on the hormonal receptors at the malignant cell."1.26[Clinical demonstrations: 1. Renal tubular acidosis; 2. Breast neoplasm with bone metastases in a man; 3. Thrombotic thrombocytopenic purpura; 4. Precocious eclampsia in a 22 years old primipara]. ( Weber, J, 1977)
"Dipyridamole and ancrod pretreatment did not influence the decrease of platelets and their accumulation in the lung after tumour cell injection."1.25The role of blood platelets in experimental metastases. ( Hilgard, P, 1973)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-199016 (72.73)18.7374
1990's3 (13.64)18.2507
2000's2 (9.09)29.6817
2010's1 (4.55)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Wenzel, J2
Zeisig, R2
Fichtner, I2
Haider, W1
Habedank, S1
D'Angelo, A1
Garzia, L1
André, A1
Carotenuto, P1
Aglio, V1
Guardiola, O1
Arrigoni, G1
Cossu, A1
Palmieri, G1
Aravind, L1
Zollo, M1
Gastpar, H4
Ambrus, JL1
Ambrus, CM1
Phillis, JW1
Wu, PH1
Liubina, LV1
Baluda, VP1
Ziablitskiĭ, VM1
Mikhal'skaia, TIu1
Lepekhin, VP1
Budd, GT1
Herzog, P1
Bukowski, RM1
Abrahamsen, AF2
Hilgard, P2
Heller, H1
Schmidt, CG1
Weber, J1
Dollinger, MR1
Krakoff, IH1
Mareel, M1
Bracke, M1
Bruyneel, E1
Van Larebeke, N1
De Mets, M2
Mareel, MM1
Zaniboni, A1
Simoncini, E1
Marpicati, P1
Montini, E1
Palazzi, M1
Pipino, G1
Marini, G1
Fedorovskaia, EO1
Pelevina, II1
Afanas'ev, GG1
Ershov, FI1
Grigorian, SS1
Migeod, F1
Gerlach, D1
Kress, M1
Hoffmann, W1
Farroukh, R1
Seeber, S1
Mamytbeková, A1
Rezábek, K1
Kacerovská, H1
Grimová, J1
Svobodová, J1

Reviews

4 reviews available for dipyridamole and Neoplasm Metastasis

ArticleYear
[Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results].
    Laryngologie, Rhinologie, Otologie, 1983, Volume: 62, Issue:12

    Topics: Animals; Bencyclane; Cell Adhesion; Cells, Cultured; Dipyridamole; Humans; Lymphocytes; Mice; Mopida

1983
Adenosine may regulate the vascular supply and thus the growth and spread of neoplastic tissues: a proposal.
    General pharmacology, 1981, Volume: 12, Issue:5

    Topics: Adenosine; Animals; Dipyridamole; Humans; Neoplasm Metastasis; Neoplasms

1981
Invasion and metastasis control: implications for increased therapeutic index of antitumor drugs.
    Cancer treatment reviews, 1990, Volume: 17, Issue:2-3

    Topics: Antineoplastic Agents; Catechin; Dipyridamole; Glycoproteins; Humans; Microtubules; Neoplasm Invasiv

1990
Anti-invasive activities of experimental chemotherapeutic agents.
    Critical reviews in oncology/hematology, 1989, Volume: 9, Issue:3

    Topics: Animals; Antineoplastic Agents; Catechin; Dipyridamole; Flavones; Flavonoids; Glucosidases; Glycosyl

1989

Trials

1 trial available for dipyridamole and Neoplasm Metastasis

ArticleYear
Phase I/II trial of dipyridamole, 5-fluorouracil, leukovorin, and mitoxantrone in metastatic breast cancer.
    Investigational new drugs, 1994, Volume: 12, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Breast Neoplasms;

1994

Other Studies

17 other studies available for dipyridamole and Neoplasm Metastasis

ArticleYear
Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation.
    International journal of pharmaceutics, 2009, Mar-31, Volume: 370, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Dipyridamole; D

2009
Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation.
    Breast cancer research and treatment, 2010, Volume: 121, Issue:1

    Topics: Animals; Antineoplastic Agents; Blood Coagulation; Blood Vessels; Cell Line, Tumor; Dipyridamole; Fe

2010
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.
    Cancer cell, 2004, Volume: 5, Issue:2

    Topics: Amino Acid Sequence; Bacterial Proteins; Breast Neoplasms; Carrier Proteins; Cell Movement; Dipyrida

2004
Platelet aggregation inhibitors in the prevention of metastasis in neoplastic disease: a review of experimental and clinical investigations.
    Journal of medicine, 1981, Volume: 12, Issue:1

    Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Depression, Chemical; Dipyridamole; D

1981
[Increase in the antitumor effect of doxorubicin by complex corrections of the status of the hemostasis system].
    Biulleten' eksperimental'noi biologii i meditsiny, 1995, Volume: 119, Issue:2

    Topics: Animals; Cell Division; Dipyridamole; Doxorubicin; Glutamates; Hemostasis; Heparin; Lung Neoplasms;

1995
Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors.
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1976, May-03, Volume: 86, Issue:1

    Topics: Aspirin; Cell Survival; Dipyridamole; Humans; Neoplasm Metastasis; Platelet Aggregation

1976
The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL).
    Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology, 1976, Aug-30, Volume: 86, Issue:3

    Topics: Animals; Aspirin; Bencyclane; Cyproheptadine; Dipyridamole; Female; Lung Neoplasms; Male; Mice; Mice

1976
Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis.
    Journal of medicine, 1977, Volume: 8, Issue:2

    Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Cell Adhesion; Dipyridamole; Dissemin

1977
[Clinical demonstrations: 1. Renal tubular acidosis; 2. Breast neoplasm with bone metastases in a man; 3. Thrombotic thrombocytopenic purpura; 4. Precocious eclampsia in a 22 years old primipara].
    Schweizerische medizinische Wochenschrift, 1977, Dec-10, Volume: 107, Issue:49

    Topics: Acidosis, Renal Tubular; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Aged; Bone Neoplasms;

1977
Hemolysis induced by 6-N-hydroxylaminopurine riboside, an adenosine analogue.
    Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:1

    Topics: Adenosine; Adult; Bilirubin; Blood Cell Count; Breast Neoplasms; Dipyridamole; Erythrocytes; Female;

1975
5-Fluorouracil and dipyridamole in metastatic breast cancer: a pilot study.
    Journal of chemotherapy (Florence, Italy), 1989, Volume: 1, Issue:4

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dipyridamole; Drug To

1989
[Suppression of Lewis carcinoma metastasis in mice by an interferon-inducing vasodilator curantil].
    Biulleten' eksperimental'noi biologii i meditsiny, 1989, Volume: 107, Issue:1

    Topics: Animals; Dipyridamole; Drug Evaluation; Female; Interferon Inducers; Mice; Mice, Inbred C57BL; Neopl

1989
[Sequential treatment of progressive metastatic colorectal cancer with 5-fluorouracil/folinic acid, dipyramidole and mitomycin C].
    Onkologie, 1988, Volume: 11 Suppl 2

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dipyridamole; Dos

1988
Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.
    Neoplasma, 1986, Volume: 33, Issue:4

    Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred

1986
The effect of acetylsalicylic acid and dipyridamole on platelet economy in metastatic cancer.
    Scandinavian journal of haematology, 1972, Volume: 9, Issue:6

    Topics: Aspirin; Blood Cell Count; Blood Platelets; Cell Survival; Dipyridamole; Half-Life; Humans; Neoplasm

1972
The role of blood platelets in experimental metastases.
    British journal of cancer, 1973, Volume: 28, Issue:5

    Topics: Animals; Blood Cell Count; Blood Platelets; Carcinoma 256, Walker; Chromium; Chromium Isotopes; Dipy

1973
Inhibition of cancer cell stickiness by the blocking of platelet aggregation.
    South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Mar-30, Volume: 48, Issue:15

    Topics: Adhesiveness; Animals; Antineoplastic Agents; Blood Cell Count; Blood Platelets; Capillaries; Carcin

1974