dipyridamole has been researched along with Neoplasm Metastasis in 22 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Based upon the hypothesis that dipyridamole would potentiate the cytotoxicity of mitoxantrone and the combination of 5-fluorouracil (5-FU) and leukovorin, we performed a phase I/II trial of the combination of dipyridamole, 5-FU, leukovorin, and mitoxantrone in patients with metastatic breast cancer." | 9.07 | Phase I/II trial of dipyridamole, 5-fluorouracil, leukovorin, and mitoxantrone in metastatic breast cancer. ( Budd, GT; Bukowski, RM; Herzog, P, 1994) |
| "In an attempt to increase the clinical activity of 5-fluorouracil (5-FU) by blocking the thymidine salvage pathway, 15 patients with refractory metastatic breast cancer (MBC) were treated with oral dipyridamole (D): 75 mg p." | 7.67 | 5-Fluorouracil and dipyridamole in metastatic breast cancer: a pilot study. ( Marini, G; Marpicati, P; Montini, E; Palazzi, M; Pipino, G; Simoncini, E; Zaniboni, A, 1989) |
| "Mitomycin C was given to 9 patients as a third-line regimen with resulting 5 NC for 2-4 months." | 5.27 | [Sequential treatment of progressive metastatic colorectal cancer with 5-fluorouracil/folinic acid, dipyramidole and mitomycin C]. ( Farroukh, R; Gerlach, D; Hoffmann, W; Kress, M; Migeod, F; Seeber, S, 1988) |
| "Based upon the hypothesis that dipyridamole would potentiate the cytotoxicity of mitoxantrone and the combination of 5-fluorouracil (5-FU) and leukovorin, we performed a phase I/II trial of the combination of dipyridamole, 5-FU, leukovorin, and mitoxantrone in patients with metastatic breast cancer." | 5.07 | Phase I/II trial of dipyridamole, 5-fluorouracil, leukovorin, and mitoxantrone in metastatic breast cancer. ( Budd, GT; Bukowski, RM; Herzog, P, 1994) |
| "Our clinical study to prevent relapse and metastases in several sarcomas and malignant lymphomas of the head and neck region with a long-term treatment with mopidamole was initiated in 1972 because the pyrimido-pyrimidine derivative was shown to inhibit platelet aggregation in vivo and to increase significantly the circulation time of intravenously injected, 32P-labelled Ehrlich ascites tumour cells in mouse blood." | 4.76 | [Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results]. ( Gastpar, H, 1983) |
| " Previously, we showed that dual liposomes simultaneously containing the hemostatic inhibitor, dipyridamole and the anticancer drug, perifosine potently inhibited metastasis, causing a 90% reduction in the number of lung metastases in a murine experimental metastasis model." | 3.76 | Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation. ( Fichtner, I; Habedank, S; Haider, W; Wenzel, J; Zeisig, R, 2010) |
| "In an attempt to increase the clinical activity of 5-fluorouracil (5-FU) by blocking the thymidine salvage pathway, 15 patients with refractory metastatic breast cancer (MBC) were treated with oral dipyridamole (D): 75 mg p." | 3.67 | 5-Fluorouracil and dipyridamole in metastatic breast cancer: a pilot study. ( Marini, G; Marpicati, P; Montini, E; Palazzi, M; Pipino, G; Simoncini, E; Zaniboni, A, 1989) |
| "In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline)." | 3.67 | Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. ( Grimová, J; Kacerovská, H; Mamytbeková, A; Rezábek, K; Svobodová, J, 1986) |
| "Formation of lung and extrapulmonary metastases after intravenous administration of MT3 breast cancer cells was significantly reduced when mice were treated with a single intravenous dose of DIP/OPP-L containing 100nmol lipid 6h before tumour cell inoculation." | 1.35 | Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation. ( Fichtner, I; Wenzel, J; Zeisig, R, 2009) |
| "Out of 59 metastatic breast cancer cases analyzed, 22 (37%) were found to overexpress h-prune, evidence that this novel enzymatic activity is involved in promoting cancer metastasis." | 1.32 | Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis. ( Aglio, V; André, A; Aravind, L; Arrigoni, G; Carotenuto, P; Cossu, A; D'Angelo, A; Garzia, L; Guardiola, O; Palmieri, G; Zollo, M, 2004) |
| "Mitomycin C was given to 9 patients as a third-line regimen with resulting 5 NC for 2-4 months." | 1.27 | [Sequential treatment of progressive metastatic colorectal cancer with 5-fluorouracil/folinic acid, dipyramidole and mitomycin C]. ( Farroukh, R; Gerlach, D; Hoffmann, W; Kress, M; Migeod, F; Seeber, S, 1988) |
| "The mechanism of the early stage of metastasis formation by sticky blood-born cancer cells is discussed." | 1.26 | Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis. ( Gastpar, H, 1977) |
| "A case of male breast carcinoma is discussed with reference to the effect of steroids on the hormonal receptors at the malignant cell." | 1.26 | [Clinical demonstrations: 1. Renal tubular acidosis; 2. Breast neoplasm with bone metastases in a man; 3. Thrombotic thrombocytopenic purpura; 4. Precocious eclampsia in a 22 years old primipara]. ( Weber, J, 1977) |
| "Dipyridamole and ancrod pretreatment did not influence the decrease of platelets and their accumulation in the lung after tumour cell injection." | 1.25 | The role of blood platelets in experimental metastases. ( Hilgard, P, 1973) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (72.73) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 2 (9.09) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wenzel, J | 2 |
| Zeisig, R | 2 |
| Fichtner, I | 2 |
| Haider, W | 1 |
| Habedank, S | 1 |
| D'Angelo, A | 1 |
| Garzia, L | 1 |
| André, A | 1 |
| Carotenuto, P | 1 |
| Aglio, V | 1 |
| Guardiola, O | 1 |
| Arrigoni, G | 1 |
| Cossu, A | 1 |
| Palmieri, G | 1 |
| Aravind, L | 1 |
| Zollo, M | 1 |
| Gastpar, H | 4 |
| Ambrus, JL | 1 |
| Ambrus, CM | 1 |
| Phillis, JW | 1 |
| Wu, PH | 1 |
| Liubina, LV | 1 |
| Baluda, VP | 1 |
| Ziablitskiĭ, VM | 1 |
| Mikhal'skaia, TIu | 1 |
| Lepekhin, VP | 1 |
| Budd, GT | 1 |
| Herzog, P | 1 |
| Bukowski, RM | 1 |
| Abrahamsen, AF | 2 |
| Hilgard, P | 2 |
| Heller, H | 1 |
| Schmidt, CG | 1 |
| Weber, J | 1 |
| Dollinger, MR | 1 |
| Krakoff, IH | 1 |
| Mareel, M | 1 |
| Bracke, M | 1 |
| Bruyneel, E | 1 |
| Van Larebeke, N | 1 |
| De Mets, M | 2 |
| Mareel, MM | 1 |
| Zaniboni, A | 1 |
| Simoncini, E | 1 |
| Marpicati, P | 1 |
| Montini, E | 1 |
| Palazzi, M | 1 |
| Pipino, G | 1 |
| Marini, G | 1 |
| Fedorovskaia, EO | 1 |
| Pelevina, II | 1 |
| Afanas'ev, GG | 1 |
| Ershov, FI | 1 |
| Grigorian, SS | 1 |
| Migeod, F | 1 |
| Gerlach, D | 1 |
| Kress, M | 1 |
| Hoffmann, W | 1 |
| Farroukh, R | 1 |
| Seeber, S | 1 |
| Mamytbeková, A | 1 |
| Rezábek, K | 1 |
| Kacerovská, H | 1 |
| Grimová, J | 1 |
| Svobodová, J | 1 |
4 reviews available for dipyridamole and Neoplasm Metastasis
| Article | Year |
|---|---|
[Modification of metastasis formation by inhibition of platelet aggregation. Experimental and clinical results].
Topics: Animals; Bencyclane; Cell Adhesion; Cells, Cultured; Dipyridamole; Humans; Lymphocytes; Mice; Mopida | 1983 |
Adenosine may regulate the vascular supply and thus the growth and spread of neoplastic tissues: a proposal.
Topics: Adenosine; Animals; Dipyridamole; Humans; Neoplasm Metastasis; Neoplasms | 1981 |
Invasion and metastasis control: implications for increased therapeutic index of antitumor drugs.
Topics: Antineoplastic Agents; Catechin; Dipyridamole; Glycoproteins; Humans; Microtubules; Neoplasm Invasiv | 1990 |
Anti-invasive activities of experimental chemotherapeutic agents.
Topics: Animals; Antineoplastic Agents; Catechin; Dipyridamole; Flavones; Flavonoids; Glucosidases; Glycosyl | 1989 |
1 trial available for dipyridamole and Neoplasm Metastasis
| Article | Year |
|---|---|
Phase I/II trial of dipyridamole, 5-fluorouracil, leukovorin, and mitoxantrone in metastatic breast cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Breast Neoplasms; | 1994 |
17 other studies available for dipyridamole and Neoplasm Metastasis
| Article | Year |
|---|---|
Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Dipyridamole; D | 2009 |
Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation.
Topics: Animals; Antineoplastic Agents; Blood Coagulation; Blood Vessels; Cell Line, Tumor; Dipyridamole; Fe | 2010 |
Prune cAMP phosphodiesterase binds nm23-H1 and promotes cancer metastasis.
Topics: Amino Acid Sequence; Bacterial Proteins; Breast Neoplasms; Carrier Proteins; Cell Movement; Dipyrida | 2004 |
Platelet aggregation inhibitors in the prevention of metastasis in neoplastic disease: a review of experimental and clinical investigations.
Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Depression, Chemical; Dipyridamole; D | 1981 |
[Increase in the antitumor effect of doxorubicin by complex corrections of the status of the hemostasis system].
Topics: Animals; Cell Division; Dipyridamole; Doxorubicin; Glutamates; Hemostasis; Heparin; Lung Neoplasms; | 1995 |
Platelet turnover in metastatic cancer and the effect of platelet aggregation inhibitors.
Topics: Aspirin; Cell Survival; Dipyridamole; Humans; Neoplasm Metastasis; Platelet Aggregation | 1976 |
The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL).
Topics: Animals; Aspirin; Bencyclane; Cyproheptadine; Dipyridamole; Female; Lung Neoplasms; Male; Mice; Mice | 1976 |
Platelet-cancer cell interaction in metastasis formation: a possible therapeutic approcach to metastasis prophylaxis.
Topics: Animals; Bencyclane; Blood Coagulation; Carcinoma 256, Walker; Cell Adhesion; Dipyridamole; Dissemin | 1977 |
[Clinical demonstrations: 1. Renal tubular acidosis; 2. Breast neoplasm with bone metastases in a man; 3. Thrombotic thrombocytopenic purpura; 4. Precocious eclampsia in a 22 years old primipara].
Topics: Acidosis, Renal Tubular; Acute Kidney Injury; Adrenal Cortex Hormones; Adult; Aged; Bone Neoplasms; | 1977 |
Hemolysis induced by 6-N-hydroxylaminopurine riboside, an adenosine analogue.
Topics: Adenosine; Adult; Bilirubin; Blood Cell Count; Breast Neoplasms; Dipyridamole; Erythrocytes; Female; | 1975 |
5-Fluorouracil and dipyridamole in metastatic breast cancer: a pilot study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dipyridamole; Drug To | 1989 |
[Suppression of Lewis carcinoma metastasis in mice by an interferon-inducing vasodilator curantil].
Topics: Animals; Dipyridamole; Drug Evaluation; Female; Interferon Inducers; Mice; Mice, Inbred C57BL; Neopl | 1989 |
[Sequential treatment of progressive metastatic colorectal cancer with 5-fluorouracil/folinic acid, dipyramidole and mitomycin C].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dipyridamole; Dos | 1988 |
Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.
Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred | 1986 |
The effect of acetylsalicylic acid and dipyridamole on platelet economy in metastatic cancer.
Topics: Aspirin; Blood Cell Count; Blood Platelets; Cell Survival; Dipyridamole; Half-Life; Humans; Neoplasm | 1972 |
The role of blood platelets in experimental metastases.
Topics: Animals; Blood Cell Count; Blood Platelets; Carcinoma 256, Walker; Chromium; Chromium Isotopes; Dipy | 1973 |
Inhibition of cancer cell stickiness by the blocking of platelet aggregation.
Topics: Adhesiveness; Animals; Antineoplastic Agents; Blood Cell Count; Blood Platelets; Capillaries; Carcin | 1974 |