dipyridamole has been researched along with Muscle Relaxation in 32 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1% when administered intravenously at 30 microg/kg to the chronically hypoxic rats and had an apparent oral bioavailability of about 19." | 1.31 | 4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5. ( Adachi, H; Ishibashi, K; Ishihara, H; Kabasawa, Y; Kakiki, M; Kodama, K; Matsukura, M; Miyazaki, K; Nishino, M; Ozaki, H; Takase, Y; Watanabe, N, 2000) |
| "Dipyridamole or NBTI treatment, like diazepam, increased the responsiveness of rat pulmonary artery to CGS 21680, but did not influence the cardiodepressive effect of CPA in electrically driven left atrial myocardium." | 1.30 | Sensitization by chronic diazepam treatment of A2A adenosine receptor-mediated relaxation in rat pulmonary artery. ( Cseppentö, A; Kovács, P; Nagy, E; Szabó, JZ; Szentmiklósi, AJ; Ujfalusi, A, 1999) |
| "Dipyridamole appears to increase the production of PGI2 even in the presence of PG synthesis inhibition by aspirin or indomethacin." | 1.27 | Modification of angiotensin II-induced relaxation by dipyridamole, phthalazinol and aspirin in isolated dog renal arteries. ( Toda, N; Yamamoto, M, 1983) |
| "Adenosine binding was reversible and displayed a single species of saturable binding sites." | 1.26 | Demonstration of a putative adenosine receptor in rabbit aorta. ( Ghai, G; Mustafa, SJ, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (59.38) | 18.7374 |
| 1990's | 9 (28.13) | 18.2507 |
| 2000's | 4 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Takase, Y | 2 |
| Saeki, T | 1 |
| Fujimoto, M | 1 |
| Saito, I | 1 |
| Watanabe, N | 1 |
| Adachi, H | 1 |
| Ozaki, H | 1 |
| Matsukura, M | 1 |
| Miyazaki, K | 1 |
| Ishibashi, K | 1 |
| Ishihara, H | 1 |
| Kodama, K | 1 |
| Nishino, M | 1 |
| Kakiki, M | 1 |
| Kabasawa, Y | 1 |
| Kaneda, T | 1 |
| Yamamoto, H | 1 |
| Azegami, Y | 1 |
| Shimizu, K | 1 |
| Urakawa, N | 1 |
| Nakajyo, S | 1 |
| Santos-Silva, AJ | 1 |
| Cairrão, E | 1 |
| Morgado, M | 1 |
| Alvarez, E | 1 |
| Verde, I | 1 |
| Downes, H | 1 |
| Taylor, SM | 1 |
| Christie, J | 1 |
| Satchell, DG | 2 |
| Ghai, G | 1 |
| Mustafa, SJ | 2 |
| Maguire, MH | 1 |
| Toda, N | 1 |
| Yamamoto, M | 1 |
| Collis, MG | 1 |
| Brown, CM | 1 |
| Satchell, D | 2 |
| Smith, R | 1 |
| Brandt, D | 1 |
| Abe, M | 1 |
| Katsuragi, T | 1 |
| Furukawa, T | 1 |
| Davies, LP | 1 |
| Baird-Lambert, J | 1 |
| Jamieson, DD | 1 |
| Prentice, DJ | 1 |
| Shankley, NP | 1 |
| Black, JW | 1 |
| De Garavilla, L | 1 |
| Pagani, ED | 1 |
| Buchholz, RA | 1 |
| Dundore, R | 1 |
| Bode, DC | 1 |
| Volberg, ML | 1 |
| Jackson, KN | 1 |
| Pratt, P | 1 |
| Silver, PJ | 1 |
| Rubinstein, R | 1 |
| Shalev, M | 1 |
| Nissenkorn, I | 1 |
| Cohen, S | 1 |
| Ujfalusi, A | 1 |
| Cseppentö, A | 1 |
| Nagy, E | 1 |
| Szabó, JZ | 1 |
| Kovács, P | 1 |
| Szentmiklósi, AJ | 1 |
| Jones, OM | 1 |
| Brading, AF | 1 |
| McC Mortensen, NJ | 1 |
| Johansson, SR | 1 |
| Anderson, RG | 1 |
| Baer, HP | 1 |
| Frew, R | 1 |
| Burnstock, G | 1 |
| Takahashi, Y | 1 |
| Ishii, N | 1 |
| Lue, TF | 1 |
| Tanagho, EA | 1 |
| Bult, H | 1 |
| Fret, HR | 1 |
| Jordaens, FH | 1 |
| Herman, AG | 1 |
| Advenier, C | 1 |
| Devillier, P | 1 |
| Blanc, M | 1 |
| Gnassounou, JP | 1 |
| Komissarov, IV | 1 |
| Serdiuk, SE | 1 |
| Gmiro, VE | 1 |
| Tanabe, S | 1 |
| Ikeda, Y | 1 |
| Shiraki, Y | 1 |
| Sakai, K | 1 |
| Nakagawa, Y | 1 |
| Gudenzi, M | 1 |
| Farmer, SG | 1 |
| Canning, BJ | 1 |
| Wilkins, DE | 1 |
| Krzanowski, JJ | 1 |
| Urdaneta-Bohorquez, A | 1 |
| Polson, JB | 1 |
| Sakamoto, Y | 1 |
| Szentivanyi, A | 1 |
| Nishida, Y | 1 |
| Suzuki, S | 1 |
| Miyamoto, T | 1 |
| Savage, AO | 1 |
| Atanga, GK | 1 |
32 other studies available for dipyridamole and Muscle Relaxation
| Article | Year |
|---|---|
Cyclic GMP phosphodiesterase inhibitors. 1. The discovery of a novel potent inhibitor, 4-((3,4-(methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Aorta; Chromones; Coronary Vessels; Cyclic GMP; Dinopr | 1993 |
4-(3-Chloro-4-methoxybenzyl)aminophthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antihypertensive Agents; Biological Availability; Bloo | 2000 |
Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Carbachol; Cholinergic Agonists; Cyclic AMP; Cyclic GM | 2003 |
PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Colforsin; Cyclic AMP; Cyclic GMP; Cyclic Nucleotide | 2008 |
Distinctive pharmacological profile of a nonadrenergic inhibitory system in bullfrog lung.
Topics: Adenosine; Adenosine Triphosphate; Animals; Atropine; Catecholamines; Dipyridamole; Hexamethonium; H | 1983 |
Purine receptors in the trachea: is there a receptor for ATP?
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Animals; Dipyridamole; Dose-Response Relatio | 1980 |
Demonstration of a putative adenosine receptor in rabbit aorta.
Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Aorta, T | 1982 |
Evidence for separate receptors for ATP and adenosine in the guinea-pig taenia coli.
Topics: Adenosine; Animals; Colon; Dipyridamole; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques | 1982 |
Modification of angiotensin II-induced relaxation by dipyridamole, phthalazinol and aspirin in isolated dog renal arteries.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Angiotensin II; Animals; Aspirin; Cyclooxygenase Inhibitors; Di | 1983 |
Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular site.
Topics: Adenosine; Animals; Aorta; Dipyridamole; Drug Interactions; Female; Guinea Pigs; In Vitro Techniques | 1983 |
Adenosine causes contractions in spiral strips and relaxations in transverse strips of guinea-pig trachea: studies on mechanism of action.
Topics: Adenosine; Adenosine Triphosphate; Animals; Dipyridamole; Female; Guinea Pigs; In Vitro Techniques; | 1984 |
[Lusitropic behavior in patients with coronary heart disease].
Topics: Adult; Aged; Blood Pressure; Cardiac Catheterization; Cardiac Output; Cardiac Pacing, Artificial; Ca | 1984 |
Discrimination by dipyridamole of two types of responses to adenosine and ATP of the carbachol-induced contraction of guinea-pig trachea.
Topics: Adenosine; Adenosine Triphosphate; Animals; Carbachol; Dipyridamole; Female; Glucose; Guinea Pigs; I | 1983 |
Potentiation of pharmacological responses to adenosine, in vitro and in vivo.
Topics: Adenosine; Adenylyl Cyclases; Animals; Body Temperature; Brain; Dipyridamole; Drug Synergism; Guinea | 1982 |
Pharmacological analysis of the interaction between purinoceptor agonists and antagonists in the guinea-pig taenia caecum.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Binding, Competitive; Cecum; Dipyridamole; Do | 1995 |
Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analysis of Variance; Animals; Aorta, Abdominal; Blood Pressure | 1996 |
Effect of exogenous adenosine and its monophosphate on the contractile response to acetylcholine in the human isolated detrusor muscle strips.
Topics: Acetylcholine; Adenosine; Adenosine Monophosphate; Adenosine Triphosphate; Adrenergic beta-Agonists; | 1998 |
Sensitization by chronic diazepam treatment of A2A adenosine receptor-mediated relaxation in rat pulmonary artery.
Topics: Adenosine; Animals; Carrier Proteins; Diazepam; Dinucleoside Phosphates; Dipyridamole; Dose-Response | 1999 |
Phosphodiesterase inhibitors cause relaxation of the internal anal sphincter in vitro.
Topics: Adenine; Aged; Aged, 80 and over; Anal Canal; Dipyridamole; Dose-Response Relationship, Drug; Female | 2002 |
Effects of isoprenaline on the time course of the cyclic AMP level in rat uterus.
Topics: Adenosine; Animals; Catechols; Corticosterone; Cyclic AMP; Dipyridamole; Female; Guanosine Triphosph | 1978 |
Effect of dipyridamole and 6-(2-hydroxy-5-nitro)-benzylthioguanosine on low-frequency-stimulated relaxation in the guinea pig taenia coli.
Topics: Adenosine; Animals; Colon; Dipyridamole; Electric Stimulation; Female; Guanosine; Guinea Pigs; In Vi | 1977 |
Pharmacological effects of adenosine on canine penile erection.
Topics: Acetylcholine; Adenosine; Animals; Blood Flow Velocity; Blood Pressure; Cavernous Sinus; Dipyridamol | 1991 |
Dipyridamole potentiates the anti-aggregating and vasodilator activity of nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Adenosine Diphosp | 1991 |
Peripheral type benzodiazepine receptors and response to adenosine on the guinea-pig isolated trachea.
Topics: Adenosine; Animals; Benzodiazepines; Clonazepam; Diazepam; Dipyridamole; Drug Synergism; GABA-A Rece | 1990 |
[Adenosinergic neurons in intramural ganglia of the small intestine].
Topics: Adenosine; Adenosine Triphosphate; Animals; Choline; Dipyridamole; Electric Stimulation; Ileum; In V | 1990 |
Use of purine nucleotide and nucleoside metabolising enzymes as tools to determine the presence of purinergic nerve transmission in smooth muscle.
Topics: Adenosine; Adenosine Deaminase; Adenosine Triphosphate; Animals; Colon; Dipyridamole; Electric Stimu | 1989 |
Enhancement of adenosine-induced relaxant responses of the guinea-pig isolated taenia coli and aortae by a novel nootropic agent BY-1949: comparison with dipyridamole.
Topics: Adenosine; Animals; Aorta, Thoracic; Brain; Colon; Dibenzoxazepines; Dipyridamole; Drug Synergism; G | 1988 |
Calcium entry blocking activity of dilazep in dog coronary artery.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Arteries; Azepines; Calcium; Calcium Channel Block | 1986 |
Adenosine receptor-mediated contraction and relaxation of guinea-pig isolated tracheal smooth muscle: effects of adenosine antagonists.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Dipyridamole; Guinea Pigs; In Vitro Technique | 1988 |
Effects of adenosine and theophylline on canine tracheal smooth muscle tone.
Topics: Adenine; Adenosine; Animals; Dipyridamole; Dogs; Drug Interactions; In Vitro Techniques; Inosine; Ma | 1987 |
Suppression by 5'-methylthioadenosine of histamine or leukotriene-induced contraction in isolated guinea pig tracheal rings.
Topics: Adenosine; Animals; Deoxyadenosines; Dipyridamole; Dose-Response Relationship, Drug; Guinea Pigs; Hi | 1986 |
Effect of adenosine 5'triphosphate (ATP) on the isolated rectum of the rainbow lizard Agama agama.
Topics: Adenosine Triphosphate; Animals; Calcium; Calcium Chloride; Carbachol; Dipyridamole; In Vitro Techni | 1985 |