dipyridamole has been researched along with Lung Neoplasms in 24 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combined effects of adriamycin (ADM) and dipyridamole (DP) on lung metastasis of B16 melanoma cells in mice were investigated." | 7.68 | Combined treatment of adriamycin and dipyridamole inhibits lung metastasis of B16 melanoma cells in mice. ( Emi, Y; Kohnoe, S; Maehara, Y; Sakaguchi, Y; Sugimachi, K, 1990) |
| " The toxic effects of thymidylate synthase inhibition may be prevented by salvage of exogenous thymidine." | 5.27 | Potentiation of quinazoline antifolate (CB3717) toxicity by dipyridamole in human lung carcinoma, A549, cells. ( Curtin, NJ; Harris, AL, 1988) |
| "Dipyridamole is a widely prescribed drug in ischemic disorders, and it is here investigated for potential clinical use as a new treatment for breast cancer." | 3.79 | Dipyridamole prevents triple-negative breast-cancer progression. ( Bello, AM; De Martino, D; De Vita, G; Di Dato, V; Marino, N; Marshall, JC; Medaglia, C; Navas, L; Romano, A; Scoppettuolo, MN; Spano, D; Steeg, PS; Zollo, M, 2013) |
| " Previously, we showed that dual liposomes simultaneously containing the hemostatic inhibitor, dipyridamole and the anticancer drug, perifosine potently inhibited metastasis, causing a 90% reduction in the number of lung metastases in a murine experimental metastasis model." | 3.76 | Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation. ( Fichtner, I; Habedank, S; Haider, W; Wenzel, J; Zeisig, R, 2010) |
| "The combined effects of adriamycin (ADM) and dipyridamole (DP) on lung metastasis of B16 melanoma cells in mice were investigated." | 3.68 | Combined treatment of adriamycin and dipyridamole inhibits lung metastasis of B16 melanoma cells in mice. ( Emi, Y; Kohnoe, S; Maehara, Y; Sakaguchi, Y; Sugimachi, K, 1990) |
| " This study provided evidence that the combination of DP and amphotericin B (AmB) significantly potentiated the inhibitory effect of 5-fluorouracil (FU) or methotrexate (MTX) against a panel of transplantable tumors including sarcoma 180, cervical carcinoma U14, and Lewis lung carcinoma in mice." | 3.67 | Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B. ( Cao, SS; Zhen, YS, 1989) |
| "In the present study, we have examined the antimetastatic effect of flurbiprofen, a nonsteroidal antiinflammatory drug, on spontaneous metastases formation in mice bearing Lewis lung carcinoma and these results were compared with effects of other inhibitors of platelet function (mopidamole, dipyridamole, pentoxifylline)." | 3.67 | Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors. ( Grimová, J; Kacerovská, H; Mamytbeková, A; Rezábek, K; Svobodová, J, 1986) |
| " In mouse hepatoma H22 model, the triple drug combination showed synergistic and highly potent antitumor efficacy." | 1.40 | A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice. ( Li, Y; Liu, XJ; Wu, SY; Zhen, YS; Zheng, YB, 2014) |
| "Formation of lung and extrapulmonary metastases after intravenous administration of MT3 breast cancer cells was significantly reduced when mice were treated with a single intravenous dose of DIP/OPP-L containing 100nmol lipid 6h before tumour cell inoculation." | 1.35 | Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation. ( Fichtner, I; Wenzel, J; Zeisig, R, 2009) |
| " The toxic effects of thymidylate synthase inhibition may be prevented by salvage of exogenous thymidine." | 1.27 | Potentiation of quinazoline antifolate (CB3717) toxicity by dipyridamole in human lung carcinoma, A549, cells. ( Curtin, NJ; Harris, AL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (29.17) | 18.7374 |
| 1990's | 10 (41.67) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, C | 1 |
| Schwab, LP | 1 |
| Fan, M | 1 |
| Seagroves, TN | 1 |
| Buolamwini, JK | 1 |
| Liu, XJ | 1 |
| Zheng, YB | 1 |
| Li, Y | 1 |
| Wu, SY | 1 |
| Zhen, YS | 2 |
| Wenzel, J | 2 |
| Zeisig, R | 2 |
| Fichtner, I | 2 |
| Thomas, HD | 1 |
| Saravanan, K | 1 |
| Wang, LZ | 1 |
| Lin, MJ | 1 |
| Northen, JS | 1 |
| Barlow, H | 1 |
| Barton, M | 1 |
| Newell, DR | 2 |
| Griffin, RJ | 1 |
| Golding, BT | 1 |
| Curtin, NJ | 5 |
| Haider, W | 1 |
| Habedank, S | 1 |
| Spano, D | 1 |
| Marshall, JC | 1 |
| Marino, N | 1 |
| De Martino, D | 1 |
| Romano, A | 1 |
| Scoppettuolo, MN | 1 |
| Bello, AM | 1 |
| Di Dato, V | 1 |
| Navas, L | 1 |
| De Vita, G | 1 |
| Medaglia, C | 1 |
| Steeg, PS | 1 |
| Zollo, M | 1 |
| Bando, H | 1 |
| Yamashita, T | 1 |
| Tsubura, E | 1 |
| Liubina, LV | 1 |
| Baluda, VP | 1 |
| Ziablitskiĭ, VM | 1 |
| Mikhal'skaia, TIu | 1 |
| Lepekhin, VP | 1 |
| Vallejo, CT | 1 |
| Rabinovich, MG | 1 |
| Perez, JE | 1 |
| Rodriguez, R | 1 |
| Machiavelli, MR | 1 |
| Leone, BA | 1 |
| Romero, AD | 1 |
| Lacava, JA | 1 |
| Cuevas, MA | 1 |
| Langhi, MJ | 1 |
| Sugimori, H | 1 |
| Nakano, S | 2 |
| Chifu, Y | 1 |
| Mitsugi, K | 2 |
| Kudo, J | 1 |
| Ishida, T | 1 |
| Niho, Y | 2 |
| Dearing, MP | 1 |
| Englee-Miller, MJ | 1 |
| Kratzke, RA | 1 |
| Kramer, BS | 1 |
| Chu, E | 1 |
| Weinstein, J | 1 |
| Anderson, M | 1 |
| Venzon, D | 1 |
| Mulshine, JL | 1 |
| Gazdar, AF | 1 |
| Bom, HS | 2 |
| Lim, SC | 2 |
| Kim, YC | 2 |
| Song, HC | 1 |
| Min, JJ | 1 |
| Jeong, HJ | 1 |
| Kim, JY | 1 |
| Lee, J | 1 |
| Park, KO | 2 |
| Turner, DP | 1 |
| Smith, PG | 1 |
| Marshman, E | 1 |
| Calvert, AH | 1 |
| Na, KJ | 1 |
| Song, H | 1 |
| Hilgard, P | 1 |
| Heller, H | 1 |
| Schmidt, CG | 1 |
| Ichinose, I | 1 |
| Kuroki, M | 1 |
| Anzai, K | 1 |
| Nakamura, M | 1 |
| Harris, AL | 2 |
| Aherne, GW | 1 |
| Sakaguchi, Y | 1 |
| Emi, Y | 1 |
| Maehara, Y | 1 |
| Kohnoe, S | 1 |
| Sugimachi, K | 1 |
| Cao, SS | 1 |
| Mamytbeková, A | 1 |
| Rezábek, K | 1 |
| Kacerovská, H | 1 |
| Grimová, J | 1 |
| Svobodová, J | 1 |
| Gastpar, H | 2 |
3 trials available for dipyridamole and Lung Neoplasms
| Article | Year |
|---|---|
High-dose cisplatin with dipyridamole in advanced non-small cell lung cancer. A Grupo Oncológico Cooperativo del Sur study.
Topics: Adult; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dipyridamole; Drug Synergism; Drug Therapy, Combin | 1995 |
Dipyridamole modulated Tc-99m sestamibi lung SPECT in small cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; ATP Binding Cassette Transporter, Subfamily B, | 1999 |
Comparison of Tc-99m sestamibi, serum neuron-specific enolase and lactate dehydrogenase as predictors of response to chemotherapy in small cell lung cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carcinoma, Small Cell; Dipy | 2000 |
21 other studies available for dipyridamole and Lung Neoplasms
| Article | Year |
|---|---|
Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Dipyridamole; Disease | 2013 |
A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Wester | 2014 |
Inhibition of breast cancer metastasis by dual liposomes to disturb complex formation.
Topics: Animals; Antineoplastic Agents; Blood Platelets; Breast Neoplasms; Cell Line, Tumor; Dipyridamole; D | 2009 |
Preclinical evaluation of a novel pyrimidopyrimidine for the prevention of nucleoside and nucleobase reversal of antifolate cytotoxicity.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Proliferation; Dipyridamole; Drug Synergism; Female; | 2009 |
Inhibition of pulmonary metastasis in a human MT3 breast cancer xenograft model by dual liposomes preventing intravasal fibrin clot formation.
Topics: Animals; Antineoplastic Agents; Blood Coagulation; Blood Vessels; Cell Line, Tumor; Dipyridamole; Fe | 2010 |
Dipyridamole prevents triple-negative breast-cancer progression.
Topics: Animals; Apoptosis; beta Catenin; Blotting, Western; Breast Neoplasms; Cell Adhesion; Cell Cycle; Ce | 2013 |
Effects of antiplatelet agents on pulmonary metastases.
Topics: Adenosine Diphosphate; Animals; Depression, Chemical; Diltiazem; Dipyridamole; Dose-Response Relatio | 1984 |
[Increase in the antitumor effect of doxorubicin by complex corrections of the status of the hemostasis system].
Topics: Animals; Cell Division; Dipyridamole; Doxorubicin; Glutamates; Hemostasis; Heparin; Lung Neoplasms; | 1995 |
[5-fluorouracil + low-dose leucovorin and cisplatin sequential chemotherapy with dipyridamole for advanced nonresectable squamous cell carcinoma of the lung: a case report].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Squamous Cell; Cisp | 1993 |
Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10-deazaaminopterin (10-EDAM) against human lung cancer cell lines.
Topics: Aminopterin; Biological Transport; Cell Division; Depression, Chemical; Dipyridamole; Dose-Response | 1996 |
Dipyridamole-mediated reversal of multidrug resistance in MRP over-expressing human lung carcinoma cells in vitro.
Topics: Antineoplastic Agents; ATP-Binding Cassette Transporters; Cell Division; Dipyridamole; Doxorubicin; | 1999 |
Prevention of thymidine and hypoxanthine rescue from MTA (LY231514) growth inhibition by dipyridamole in human lung cancer cell lines.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Non-Small-Cell Lung; Cell Division; Dipyridamole; Enzyme | 1999 |
The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL).
Topics: Animals; Aspirin; Bencyclane; Cyproheptadine; Dipyridamole; Female; Lung Neoplasms; Male; Mice; Mice | 1976 |
[5-FU-leucovorin and cisplatin sequential chemotherapy with dipyridamole for non-small cell lung cancer (NSCLC). A pilot study for 5 cases].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Sm | 1991 |
Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
Topics: Cell Division; Cell Survival; Deoxyuracil Nucleotides; Dipyridamole; DNA Damage; Drug Synergism; Fol | 1991 |
Combined treatment of adriamycin and dipyridamole inhibits lung metastasis of B16 melanoma cells in mice.
Topics: Animals; Dipyridamole; Dose-Response Relationship, Drug; Doxorubicin; Drug Therapy, Combination; Lun | 1990 |
Potentiation of antimetabolite antitumor activity in vivo by dipyridamole and amphotericin B.
Topics: Amphotericin B; Animals; Antimetabolites, Antineoplastic; Dipyridamole; Drug Evaluation, Preclinical | 1989 |
Potentiation of quinazoline antifolate (CB3717) toxicity by dipyridamole in human lung carcinoma, A549, cells.
Topics: Carcinoma; Cell Survival; Dipyridamole; DNA; Drug Synergism; Folic Acid; Folic Acid Antagonists; Hum | 1988 |
Antimetastatic effect of flurbiprofen and other platelet aggregation inhibitors.
Topics: Animals; Antineoplastic Agents; Dipyridamole; Flurbiprofen; Lung Neoplasms; Male; Mice; Mice, Inbred | 1986 |
Inhibition of cancer cell stickiness by the blocking of platelet aggregation.
Topics: Adhesiveness; Animals; Antineoplastic Agents; Blood Cell Count; Blood Platelets; Capillaries; Carcin | 1974 |
The inhibition of the cancer stickiness by pyrimido-pyrimidine derivates induced by inhibition of platelet aggregation.
Topics: Animals; Blood Platelets; Carcinoma 256, Walker; Cell Aggregation; Dipyridamole; Injections, Intrave | 1971 |