dipyridamole has been researched along with Leukemia in 13 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In an attempt to identify the target protein, P-GP or mrp, of each MDR antagonist, verapamyl (Ver), dipyridamole (Dip), or cyclosporin A (Cy-A), this study was designed to compare the activity of the three afore-mentioned drugs and to test their combined effect on the cidal activity of vincristine (VCR) in five types of wild and the corresponding VCR-resistant cultured cell lines from human leukemia and lymphoma." | 3.70 | Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP. ( Hamano, S; Hirose, M; Hosoi, E; Kuroda, Y; Morimoto, M, 1998) |
| "S49 mouse leukemia cells exhibit both equilibrative and Na(+)-dependent, concentrative formycin B transport." | 3.68 | Mycoplasma contamination greatly enhances the apparent transport and concentrative accumulation of formycin B by mammalian cell culture. ( Plagemann, PG, 1991) |
| "The dose-response curves for the inhibition of equilibrative uridine transport by dilazep, dipyridamole and nitrobenzylthioinosine (NBMPR) in undifferentiated HL-60 cells were biphasic." | 1.29 | Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C. ( Lee, CW, 1994) |
| "Dipyridamole could prove to be a useful drug for reversing the drug resistance caused by the activation of the salvage pathway." | 1.29 | Mechanism of the discrepant effect of a combination of methotrexate plus dipyridamole on human hematologic cell lines. ( Hirose, M; Kuroda, Y; Takeda, E, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (30.77) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Peng, M | 1 |
| Li, Y | 1 |
| Zhang, J | 1 |
| Wu, Y | 1 |
| Yang, X | 1 |
| Lei, Y | 1 |
| Ye, M | 1 |
| Liu, J | 1 |
| Han, X | 1 |
| Kuang, Y | 1 |
| Zhao, X | 1 |
| Chen, F | 1 |
| Adema, AD | 1 |
| Smid, K | 1 |
| Losekoot, N | 1 |
| Honeywell, RJ | 1 |
| Verheul, HM | 1 |
| Myhren, F | 1 |
| Sandvold, ML | 1 |
| Peters, GJ | 1 |
| Karim, H | 1 |
| Bogason, A | 1 |
| Bhuiyan, H | 1 |
| Fotoohi, AK | 1 |
| Lafolie, P | 1 |
| Vitols, S | 1 |
| Kanno, S | 1 |
| Hiura, T | 1 |
| Ohtake, T | 1 |
| Koiwai, K | 1 |
| Suzuki, H | 1 |
| Ujibe, M | 1 |
| Ishikawa, M | 1 |
| Horber, DH | 1 |
| Schott, H | 1 |
| Schwendener, RA | 1 |
| Lee, CW | 1 |
| Hirose, M | 3 |
| Takeda, E | 2 |
| Kuroda, Y | 3 |
| Hosoi, E | 1 |
| Hamano, S | 1 |
| Morimoto, M | 1 |
| Hait, WN | 1 |
| Weiss, B | 1 |
| Plagemann, PG | 1 |
| Ninomiya, T | 1 |
| Miyao, M | 1 |
| Wasserman, LR | 1 |
| Parks, RE | 1 |
| Dawicki, DD | 1 |
| Agarwal, KC | 1 |
| Chen, SF | 1 |
| Stoeckler, JD | 1 |
13 other studies available for dipyridamole and Leukemia
| Article | Year |
|---|---|
Vector-independent transmembrane transport of oligodeoxyribonucleotides involves p38 mitogen activated protein kinase phosphorylation.
Topics: Adolescent; Adult; Aged; Biological Transport; Child; Child, Preschool; Cytoplasm; Dipyridamole; Fem | 2017 |
Metabolism and accumulation of the lipophilic deoxynucleoside analogs elacytarabine and CP-4126.
Topics: Antineoplastic Agents; Cell Line; Cytarabine; Deoxycytidine; Deoxycytidine Kinase; Dipyridamole; Dru | 2012 |
Comparison of uptake mechanisms for anthracyclines in human leukemic cells.
Topics: Anthracyclines; Antibiotics, Antineoplastic; Apoptosis; ATP Binding Cassette Transporter, Subfamily | 2013 |
Characterization of resistance to cytosine arabinoside (Ara-C) in NALM-6 human B leukemia cells.
Topics: Cell Line, Tumor; Cell Survival; Cytarabine; Cytidine Deaminase; Cytoprotection; Deoxycytidine Kinas | 2007 |
Cellular pharmacology of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine in the human leukemic cell lines K-562 and U-937.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Arabinofuranosylcytosine Triphosphate; Cell | 1995 |
Decrease in equilibrative uridine transport during monocytic differentiation of HL-60 leukaemia: involvement of protein kinase C.
Topics: Affinity Labels; Alkaloids; Binding Sites; Biological Transport; Cell Differentiation; Dilazep; Dipy | 1994 |
Mechanism of the discrepant effect of a combination of methotrexate plus dipyridamole on human hematologic cell lines.
Topics: Adult; Cell Division; Child; Dipyridamole; Drug Resistance; Drug Screening Assays, Antitumor; Drug S | 1993 |
Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP.
Topics: Antineoplastic Agents, Phytogenic; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Bind | 1998 |
Cyclic nucleotide phosphodiesterase of normal and leukemic lymphocytes. Kinetic properties and selective alteration of the activity of the multiple molecular forms.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Calmodulin; Cycli | 1979 |
Mycoplasma contamination greatly enhances the apparent transport and concentrative accumulation of formycin B by mammalian cell culture.
Topics: Animals; Biological Transport; Carrier Proteins; Dipyridamole; Formycins; Leukemia; Membrane Protein | 1991 |
Inhibitory effect of dipyridamole on the growth of various human hematologic malignant cell lines.
Topics: Adolescent; Adult; Child; Child, Preschool; Dipyridamole; DNA, Neoplasm; Female; Humans; Infant; Inf | 1986 |
A cooperative study of polycythemia vera.
Topics: Aspirin; Chlorambucil; Dipyridamole; Humans; Leukemia; Polycythemia Vera; Prognosis | 1985 |
Role of nucleoside transport in drug action. The adenosine deaminase inhibitor, deoxycoformycin, and the antiplatelet drugs, dipyridamole and dilazep.
Topics: Adenosine Deaminase; Adenosine Deaminase Inhibitors; Azepines; Biological Transport, Active; Cell Li | 1985 |