dipyridamole has been researched along with Leukemia P388 in 10 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Leukemia P388: An experimental lymphocytic leukemia originally induced in DBA/2 mice by painting with methylcholanthrene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dipyridamole, a nucleoside membrane transport inhibitor, enhanced the cytotoxicity of epirubicin for mouse leukemia P388 cells by a factor of 1." | 3.69 | [Studies on reversing effect of multidrug resistance by dipyridamole. I. modulation of epirubicin-induced effects on cell proliferation and cell cycle by dipyridamole]. ( Furusawa, S; Hayashi, A; Sasaki, K; Takayanagi, M; Takayanagi, Y, 1996) |
| "Dipyridamole alone was minimally cytotoxic in both of the doxorubicin-resistant cell line (P388/DOX) and the sensitive parent cell line (P388/S), but reversed pirarubicin-resistance in a dose-related manner in P388/DOX cells." | 1.28 | Potentiation of pirarubicin cytotoxicity by dipyridamole in doxorubicin-resistant mouse P388 leukemia cells. ( Fujimura, T; Furusawa, S; Kawauchi, H; Sasaki, K; Takayanagi, Y, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, P | 1 |
| Chien, PY | 1 |
| Khan, AR | 1 |
| Sheikh, S | 1 |
| Ali, SM | 1 |
| Ahmad, MU | 1 |
| Ahmad, I | 1 |
| Hayashi, A | 2 |
| Furusawa, S | 3 |
| Takayanagi, M | 2 |
| Takayanagi, Y | 2 |
| Sasaki, K | 3 |
| Takasyanagi, Y | 1 |
| Lum, CT | 1 |
| Marz, R | 1 |
| Plagemann, PG | 4 |
| Wohlhueter, RM | 2 |
| Ramu, A | 2 |
| Ramu, N | 2 |
| Rosario, LM | 1 |
| Fujimura, T | 1 |
| Kawauchi, H | 1 |
| Aran, JM | 1 |
| Woffendin, C | 1 |
10 other studies available for dipyridamole and Leukemia P388
| Article | Year |
|---|---|
In-vitro and in-vivo anti-cancer activity of a novel gemcitabine-cardiolipin conjugate.
Topics: Animals; Antineoplastic Agents; Body Weight; Cardiolipins; Cell Proliferation; Deoxycytidine; Dipyri | 2006 |
[Studies on reversing effect of multidrug resistance by dipyridamole. I. modulation of epirubicin-induced effects on cell proliferation and cell cycle by dipyridamole].
Topics: Animals; Antibiotics, Antineoplastic; Cell Cycle; Cell Division; Dipyridamole; Dose-Response Relatio | 1996 |
[Studies on reversing effect of multidrug resistance by dipyridamole. II. Inhibition of epirubicin efflux from resistant cells by dipyridamole and its pharmacological effect].
Topics: Animals; Antibiotics, Antineoplastic; Dipyridamole; Dose-Response Relationship, Drug; Drug Resistanc | 1996 |
Adenosine transport and metabolism in mouse leukemia cells and in canine thymocytes and peripheral blood leukocytes.
Topics: Adenosine; Adenosine Triphosphate; Animals; Biological Transport; Coformycin; Concanavalin A; Dipyri | 1979 |
Circumvention of multidrug-resistance in P388 cells is associated with a rise in the cellular content of phosphatidylcholine.
Topics: Animals; Cell Membrane; Cell Membrane Permeability; Choline; Digitonin; Dipyridamole; Drug Resistanc | 1991 |
Potentiation of pirarubicin cytotoxicity by dipyridamole in doxorubicin-resistant mouse P388 leukemia cells.
Topics: Animals; Cell Survival; Dipyridamole; Doxorubicin; Drug Resistance; Drug Synergism; Leukemia P388; T | 1991 |
Na(+)-dependent, active nucleoside transport in mouse spleen lymphocytes, leukemia cells, fibroblasts and macrophages, but not in equivalent human or pig cells; dipyridamole enhances nucleoside salvage by cells with both active and facilitated transport.
Topics: Animals; Biological Transport, Active; Cells, Cultured; Dipyridamole; Fibroblasts; Formycins; Humans | 1990 |
Use of formycin B as a general substrate for measuring facilitated nucleoside transport in mammalian cells.
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport, Active; Cell Line; Dipyridamole; Formyci | 1989 |
Circumvention of adriamycin resistance by dipyridamole analogues: a structure-activity relationship study.
Topics: Animals; Dipyridamole; Doxorubicin; Drug Resistance; Leukemia P388; Leukemia, Experimental; Mice; Mo | 1989 |
Effects of nucleoside transport inhibitors on the salvage and toxicity of adenosine and deoxyadenosine in L1210 and P388 mouse leukemia cells.
Topics: Adenosine; Animals; Biological Transport; Coformycin; Deoxyadenosines; Dipyridamole; Inosine; Leukem | 1985 |