dipyridamole has been researched along with Lesch-Nyhan Syndrome in 2 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Lesch-Nyhan Syndrome: An inherited disorder transmitted as a sex-linked trait and caused by a deficiency of an enzyme of purine metabolism; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE. Affected individuals are normal in the first year of life and then develop psychomotor retardation, extrapyramidal movement disorders, progressive spasticity, and seizures. Self-destructive behaviors such as biting of fingers and lips are seen frequently. Intellectual impairment may also occur but is typically not severe. Elevation of uric acid in the serum leads to the development of renal calculi and gouty arthritis. (Menkes, Textbook of Child Neurology, 5th ed, pp127)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Garcia-Gil, M | 1 |
| Pesi, R | 1 |
| Perna, S | 1 |
| Allegrini, S | 1 |
| Giannecchini, M | 1 |
| Camici, M | 1 |
| Tozzi, MG | 1 |
| Burnstock, G | 1 |
1 review available for dipyridamole and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
The purinergic nerve hypothesis.
Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Autonomi | 1977 |
1 other study available for dipyridamole and Lesch-Nyhan Syndrome
| Article | Year |
|---|---|
5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells.
Topics: 5'-Nucleotidase; Acetylcholine; Aminoimidazole Carboxamide; Apoptosis; Brain; Caspase 3; Caspases; C | 2003 |