Page last updated: 2024-10-26

dipyridamole and Hemolysis

dipyridamole has been researched along with Hemolysis in 19 studies

Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

Research Excerpts

ExcerptRelevanceReference
"Hemolysis is a frequent adverse effect of ribavirin (RBV)."9.11Low membrane protein sulfhydrils but not G6PD deficiency predict ribavirin-induced hemolysis in hepatitis C. ( Bihl, F; Grattagliano, I; Jüni, P; Lauterburg, BH; Palasciano, G; Palmieri, VO; Portincasa, P; Russmann, S, 2004)
"Hemolysis is a frequent adverse effect of ribavirin (RBV)."5.11Low membrane protein sulfhydrils but not G6PD deficiency predict ribavirin-induced hemolysis in hepatitis C. ( Bihl, F; Grattagliano, I; Jüni, P; Lauterburg, BH; Palasciano, G; Palmieri, VO; Portincasa, P; Russmann, S, 2004)
"Today, treatment of chronic hepatitis C is based on a synergistic combination of pegylated interferon and ribavirin with antiprotease inhibitors."3.78A new tool to study ribavirin-induced haemolysis. ( Brochot, E; Capron, D; Castelain, S; Duchaussoy, I; Duverlie, G; François, C; Helle, F; Nguyen-Khac, E; Van Nhien, AN, 2012)
"WBC-reduced RBC suspensions (30% Hct) were treated with 1,9-dimethylmethylene blue and red light, and the influence of the inclusion of DIP on photohemolysis was assessed as a function of sensitizer concentration, light dose, and storage time."3.71The band III ligand dipyridamole protects human RBCs during photodynamic treatment while extracellular virus inactivation is not affected. ( Besselink, GA; Blokker, DE; Brand, A; De Korte, D; Korsten, HG; Lagerberg, JW; Van Engelenburg, FA; Verhoeven, AJ, 2002)
"Dipyridamole was also inactive in vitro, unless red blood cell injury was deliberately enhanced, thereby increasing the level of free adenine nucleotides."2.67Dipyridamole potentiates platelet inhibition by nitric oxide. ( Bult, H; Fret, HR; Herman, AG; Jordaens, FH, 1991)
"Erythrocytes from patients with Huntington's disease showed no significant differences from erythrocytes of normal adults."1.26Lysophosphatidylcholine-induced lysis of erythrocytes in Duchenne and myotonic dystrophies and in Huntington's disease. ( Barr, AN; Danon, MJ; Lazowski, E; Omachi, A; Podolski, JL; Sarpel, G, 1982)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-199012 (63.16)18.7374
1990's1 (5.26)18.2507
2000's4 (21.05)29.6817
2010's1 (5.26)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Zhelankin, AV1
Iulmetova, LN1
Sharova, EI1
Brochot, E1
François, C1
Castelain, S1
Helle, F1
Van Nhien, AN1
Duchaussoy, I1
Capron, D1
Nguyen-Khac, E1
Duverlie, G1
Besselink, GA2
Van Engelenburg, FA2
Korsten, HG1
Blokker, DE1
Lagerberg, JW1
Brand, A1
De Korte, D2
Verhoeven, AJ2
Ebbing, IG1
Hilarius, PM1
DEUTICKE, B1
DUHM, J1
GERLACH, E1
Grattagliano, I1
Russmann, S1
Palmieri, VO1
Jüni, P1
Bihl, F1
Portincasa, P1
Palasciano, G1
Lauterburg, BH1
Omachi, A1
Sarpel, G1
Podolski, JL1
Barr, AN1
Lazowski, E1
Danon, MJ1
Häussinger, G1
Pfennigs, H1
Chelapurath, A1
Reul, H1
Essers, U1
Ruggiero, AC1
Nepomuceno, MF1
Jacob, RF1
Dorta, DJ1
Tabak, M1
Dale, J1
Myhre, E1
Rootwelt, K1
Dollinger, MR1
Krakoff, IH1
Bult, H1
Fret, HR1
Jordaens, FH1
Herman, AG1
Gewirtz, H1
Brown, P1
Most, AS1
Ferber, E1
Munder, PG1
Kohlschütter, A1
Fischer, H1
Nishino, T1
Manohitharajah, SM1
Rahman, AN1
Donnelly, RJ1
Deverall, PB1
Watson, DA1
Di Perri, T1
Auteri, A1
Volpi, L1
Odake, K1
Ambrus, JL1
Bishop, C1
Philipp, G1
Ruckpaul, K1
Banaschak, H1
Jung, F1

Trials

2 trials available for dipyridamole and Hemolysis

ArticleYear
Low membrane protein sulfhydrils but not G6PD deficiency predict ribavirin-induced hemolysis in hepatitis C.
    Hepatology (Baltimore, Md.), 2004, Volume: 39, Issue:5

    Topics: Adult; Antiviral Agents; Cell Membrane; Dipyridamole; Erythrocytes; Female; Glutathione; Glutathione

2004
Dipyridamole potentiates platelet inhibition by nitric oxide.
    Thrombosis and haemostasis, 1991, Sep-02, Volume: 66, Issue:3

    Topics: Adult; Dipyridamole; Double-Blind Method; Drug Synergism; Endothelium, Vascular; Female; Hemolysis;

1991

Other Studies

17 other studies available for dipyridamole and Hemolysis

ArticleYear
The Impact of the Anticoagulant Type in Blood Collection Tubes on Circulating Extracellular Plasma MicroRNA Profiles Revealed by Small RNA Sequencing.
    International journal of molecular sciences, 2022, Sep-07, Volume: 23, Issue:18

    Topics: Adenosine; Adult; Anticoagulants; Blood Specimen Collection; Circulating MicroRNA; Citrates; Dipyrid

2022
A new tool to study ribavirin-induced haemolysis.
    Antiviral therapy, 2012, Volume: 17, Issue:7

    Topics: Adenosine Triphosphate; Adult; Anemia, Hemolytic; Dipyridamole; Drug Evaluation, Preclinical; Drug T

2012
The band III ligand dipyridamole protects human RBCs during photodynamic treatment while extracellular virus inactivation is not affected.
    Transfusion, 2002, Volume: 42, Issue:6

    Topics: Anion Exchange Protein 1, Erythrocyte; Diarrhea Viruses, Bovine Viral; Dipyridamole; Encephalomyocar

2002
Additive effects of dipyridamole and Trolox in protecting human red cells during photodynamic treatment.
    Vox sanguinis, 2003, Volume: 85, Issue:1

    Topics: Antioxidants; Cell Membrane Permeability; Chromans; Dipyridamole; Drug Combinations; Drug Synergism;

2003
[ALTERATION OF THE MONOSACCHARIDE PERMEABILITY OF HUMAN ERYTHROCYTES BY A PYRIMIDO-PYRIMIDINE COMPOUND].
    Pflugers Archiv fur die gesamte Physiologie des Menschen und der Tiere, 1964, Jul-30, Volume: 280

    Topics: Carbohydrate Metabolism; Cell Membrane Permeability; Dipyridamole; Erythrocytes; Hematocrit; Hemolys

1964
Lysophosphatidylcholine-induced lysis of erythrocytes in Duchenne and myotonic dystrophies and in Huntington's disease.
    Journal of the neurological sciences, 1982, Volume: 56, Issue:2-3

    Topics: Adult; Child; Dipyridamole; Dose-Response Relationship, Drug; Erythrocytes; Hemolysis; Humans; Hunti

1982
[Influence of platelet aggregation inhibitors on platelet damage at prosthetic heart valves in-vitro (author's transl)].
    Biomedizinische Technik. Biomedical engineering, 1981, Volume: 26, Issue:5

    Topics: Aspirin; Blood Platelets; Dipyridamole; Heart Valve Prosthesis; Hemolysis; Humans; Lysine; Platelet

1981
Antioxidant effect of dipyridamole (DIP) and its derivative RA 25 upon lipid peroxidation and hemolysis in red blood cells.
    Physiological chemistry and physics and medical NMR, 2000, Volume: 32, Issue:1

    Topics: Animals; Antioxidants; Cells, Cultured; Dipyridamole; Dose-Response Relationship, Drug; Erythrocyte

2000
Effects of dipyridamole and acetylsalicylic acid on platelet functions in patients with aortic ball-valve prostheses.
    American heart journal, 1975, Volume: 89, Issue:5

    Topics: Aortic Valve; Aspirin; Blood Platelets; Cell Survival; Dipyridamole; Half-Life; Heart Valve Prosthes

1975
Hemolysis induced by 6-N-hydroxylaminopurine riboside, an adenosine analogue.
    Clinical pharmacology and therapeutics, 1975, Volume: 17, Issue:1

    Topics: Adenosine; Adult; Bilirubin; Blood Cell Count; Breast Neoplasms; Dipyridamole; Erythrocytes; Female;

1975
Measurement of plasma adenosine concentration: methodological and physiological considerations.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 185, Issue:1

    Topics: Adenine; Adenosine; Dipyridamole; Erythrocytes; False Positive Reactions; Hemolysis; Humans; Indicat

1987
[Studies on the lysolecithin-metabolizing enzymes of intact erythrocytes and modified stromas].
    Folia haematologica (Leipzig, Germany : 1928), 1968, Volume: 90, Issue:2

    Topics: Acyltransferases; Adenosine Triphosphate; Amitriptyline; Antibodies; Cell Membrane; Chlorpromazine;

1968
[Studies on platelet adhesiveness. I. The effects of various drugs in vitro].
    Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society, 1970, Volume: 33, Issue:5

    Topics: Adenosine; Adenosine Diphosphate; Dipyridamole; Fibrinolysin; Fibrinolytic Agents; Glucose; Hematocr

1970
Platelet survival in patients with homograft and prosthetic heart valves. Correlation with incidence of thromboembolism.
    Thorax, 1974, Volume: 29, Issue:6

    Topics: Anticoagulants; Blood Cell Count; Blood Platelet Disorders; Blood Platelets; Cell Survival; Chromium

1974
[Anti-complement action of dipyridamole. Localization of the point of attack of the drug].
    Bollettino della Societa italiana di biologia sperimentale, 1971, Nov-30, Volume: 47, Issue:22

    Topics: Complement System Proteins; Dipyridamole; Hemolysis; Humans

1971
Assay for erythrocyte adenosine monophosphate deaminase (AMP aminohydrolase, EC 3.5.4.6) and effects of certain blood preservatives on this enzyme.
    American journal of clinical pathology, 1969, Volume: 52, Issue:5

    Topics: Adenine; Adenine Nucleotides; Aminohydrolases; Blood Preservation; Chromatography, Ion Exchange; Dep

1969
[Effect of dipyridamole on blood preservation].
    Acta biologica et medica Germanica, 1969, Volume: 23, Issue:6

    Topics: Adenosine Triphosphate; Blood Preservation; Dipyridamole; Erythrocytes; Glyceric Acids; Hemolysis; H

1969