dipyridamole has been researched along with Glioblastoma in 4 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Upon treatment with dipyridamole, human U87 glioma cells decreased cell viability, clonogenic colonization, migration, and invasion, along with Noxa upregulation, Endoplasmic Reticulum (ER) stress, impaired autophagic flux, Yes-associated Protein 1 (YAP1) phosphorylation, and YAP1 reduction." | 1.72 | Endoplasmic Reticulum Stress Contributed to Dipyridamole-Induced Impaired Autophagic Flux and Glioma Apoptosis. ( Chang, CY; Chen, CJ; Chen, WY; Kuan, YH; Liao, SL; Wang, JD; Wang, WY; Wu, CC, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, L | 1 |
| Yu, J | 1 |
| Pan, H | 1 |
| Hu, P | 1 |
| Hao, Y | 1 |
| Cai, W | 1 |
| Zhu, H | 1 |
| Yu, AD | 1 |
| Xie, X | 1 |
| Ma, D | 1 |
| Yuan, J | 1 |
| Chang, CY | 1 |
| Wu, CC | 1 |
| Wang, JD | 1 |
| Liao, SL | 1 |
| Chen, WY | 1 |
| Kuan, YH | 1 |
| Wang, WY | 1 |
| Chen, CJ | 1 |
| Caciagli, F | 1 |
| Ciccarelli, R | 1 |
| Ciancetta, S | 1 |
| Di Iorio, P | 1 |
| Caciagli, P | 1 |
| Stewart, DJ | 1 |
| Dahrouge, S | 1 |
| Agboola, O | 1 |
| Girard, A | 1 |
1 trial available for dipyridamole and Glioblastoma
| Article | Year |
|---|---|
Cranial radiation and concomitant cisplatin and mitomycin-C plus resistance modulators for malignant gliomas.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; beta Carotene; Brain Neoplasms; Cisplat | 1997 |
3 other studies available for dipyridamole and Glioblastoma
| Article | Year |
|---|---|
Small molecule regulators of autophagy identified by an image-based high-throughput screen.
Topics: Autophagy; Calcium Channel Blockers; Cell Line, Tumor; Drug Evaluation, Preclinical; Fluspirilene; G | 2007 |
Endoplasmic Reticulum Stress Contributed to Dipyridamole-Induced Impaired Autophagic Flux and Glioma Apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Autophagy; Cell Line, Tumor; Dipyridamole; Endoplasmic Reticulum S | 2022 |
Adenosine--norepinephrine interactions on cyclic AMP generating system in human tumoral brain slices.
Topics: Adenosine; Adult; Aged; Brain Neoplasms; Cyclic AMP; Dipyridamole; Dose-Response Relationship, Drug; | 1982 |