dipyridamole has been researched along with Experimental Neoplasms in 21 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dipyridamole is a non-specific inhibitor of nucleoside transport into mammalian cells." | 1.27 | The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat. ( Calvert, AH; Harrap, KR; Newell, DR; O'Connor, PM, 1986) |
| "Novikoff rat hepatoma cells were propagated in suspension culture in the presence of 1 micron methotrexate and various concentrations of hypoxanthine (or adenosine plus guanosine) and thymidine and with or without the inhibitor of nucleoside and purine transport, Persantin (dipyridamole)." | 1.26 | Growth rate of cultured Novikoff rat hepatoma cells as a function of the rate of thymidine and hypoxanthine transport. ( Marz, R; Plagemann, PG; Wohlhueter, RM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (85.71) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Green, RD | 2 |
| Belt, JA | 1 |
| Ford, JM | 1 |
| Jansen, WJ | 2 |
| Pinedo, HM | 2 |
| Kuiper, CM | 1 |
| Lincke, C | 1 |
| Bamberger, U | 2 |
| Heckel, A | 1 |
| Boven, E | 2 |
| van der Wilt, CL | 1 |
| Feller, N | 1 |
| Hilgard, P | 1 |
| Heller, H | 1 |
| Schmidt, CG | 1 |
| Zylka, JM | 1 |
| Plagemann, PG | 11 |
| Behrens, M | 1 |
| Stanberry, LR | 1 |
| Marz, R | 1 |
| Wohlhueter, RM | 1 |
| Newell, DR | 1 |
| O'Connor, PM | 1 |
| Calvert, AH | 1 |
| Harrap, KR | 1 |
| Schmähl, D | 2 |
| Stackelberg, S | 1 |
| Roth, MF | 1 |
| Renner, ED | 1 |
| Bernlohr, RW | 1 |
| Erbe, J | 4 |
| Richey, DP | 1 |
| Höllenriegel, K | 1 |
| Mundt, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Comparative Analysis of the Th17 Cellular Response in Active and Inactive Pemphigus Vulgaris Patients[NCT04096222] | 42 participants (Anticipated) | Observational | 2021-06-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for dipyridamole and Experimental Neoplasms
| Article | Year |
|---|---|
Modulators of multidrug resistance. Preclinical studies.
Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological | 1995 |
Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Cell Membrane; Cell Transfo | 1974 |
19 other studies available for dipyridamole and Experimental Neoplasms
| Article | Year |
|---|---|
Effects of exogenous adenosine deaminase and erythro-9-(2-hydroxy-3-nonyl) adenine on intracellular cyclic AMP levels in C1300 murine neuroblastoma in tissue culture.
Topics: Adenine; Adenosine; Adenosine Deaminase; Animals; Cell Line; Culture Techniques; Cyclic AMP; Dipyrid | 1980 |
Heterogeneity of nucleoside transport in mammalian cells. Two types of transport activity in L1210 and other cultured neoplastic cells.
Topics: 4-Chloromercuribenzenesulfonate; Animals; Biological Transport; Cell Line; Diffusion; Dipyridamole; | 1983 |
Biochemical modulation of 'classical' multidrug resistance by BIBW22BS, a potent derivative of dipyridamole.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Dipyridamole; Doxorubicin; Drug Re | 1994 |
The influence of BIBW22BS, a dipyridamole derivative, on the antiproliferative effects of 5-fluorouracil, methotrexate and gemcitabine in vitro and in human tumour xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deoxycytidine; Dipyridamole; | 1995 |
The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL).
Topics: Animals; Aspirin; Bencyclane; Cyproheptadine; Dipyridamole; Female; Lung Neoplasms; Male; Mice; Mice | 1976 |
Purine and pyrimidine transport by cultured Novikoff cells. Specificities and mechanism of transport and relationship to phosphoribosylation.
Topics: Adenine; Animals; Biological Transport, Active; Calorimetry; Carcinoma, Hepatocellular; Cell Line; C | 1975 |
Inhibition of de novo pyrimidine nucleotide and DNA synthesis and growth of cultured Novikoff rat hepatoma cells and other cell lines by pyrazofurin (NSC 143095).
Topics: Adenosine; Amides; Anti-Bacterial Agents; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; | 1976 |
Elevation of cyclic AMP in C-1300 murine neuroblastoma by adenosine and related compounds and the antagonism of this response by methylxanthines.
Topics: Adenosine; Animals; Cell Line; Cyclic AMP; Dipyridamole; Mice; Neoplasms, Experimental; Neuroblastom | 1977 |
Growth rate of cultured Novikoff rat hepatoma cells as a function of the rate of thymidine and hypoxanthine transport.
Topics: Adenosine; Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; | 1977 |
The effect of the nucleoside transport inhibitor dipyridamole on the incorporation of [3H]thymidine in the rat.
Topics: Animals; Binding Sites; Blood Proteins; Bone Marrow; Carcinoma 256, Walker; Digestive System; Dipyri | 1986 |
[The effect of lactoflavin, nicotinic acid amide or dipyridamol on the cancerogenic action of diethylnitrosamine in rats].
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Dipyridamole; Female; Kidney; Liver; Liver Neoplasm | 1968 |
Permeation as the rate-limiting step in the phosphorylation of uridine and choline and their incorporation into macromolecules by Novikoff hepatoma cells. Competitive inhibition by phenethyl alcohol, persantin, and adenosine.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane Permeability; Cel | 1969 |
Nucleoside transport by Novikoff rat hepatoma cells glowing in suspension culture. Specificity and mechanism of transport reactions and relationship to nucleoside incorporation into nucleic acids.
Topics: Adenosine; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chloromercur | 1971 |
Permeation of glucose by simple and facilitated diffusion by Novikoff rat hepatoma cells in suspension culture and its relationship to glucose metabolism.
Topics: Animals; Biological Transport; Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Frac | 1972 |
Thymidine transport by cultured Novikoff hepatoma cells and uptake by simple diffusion and relationship to incorporation into deoxyribonucleic acid.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell-Free System; Chloromercuri | 1972 |
Transport and metabolism of glucosamine by cultured Novikoff rat hepatoma cells and effects on nucleotide pools.
Topics: Adenine Nucleotides; Adenosine; Animals; Biological Transport; Carbon Dioxide; Carbon Isotopes; Carc | 1973 |
Intracellular conversions of deoxyribonucleosides by Novikoff rat hepatoma cells and effects of hydroxyurea.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cycloheximide; Cytidine; Deamination | 1974 |
The deoxyribonucleoside transport systems of cultured Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane Permeability; Cel | 1974 |
[Investigations in multi-step-therapy of cancer (according to M. v. Ardenne) in animal experiments (author's transl)].
Topics: Animals; Ascorbic Acid; Benzopyrenes; Carcinoma; Carcinoma, Ehrlich Tumor; Dipyridamole; Female; Glu | 1974 |