dipyridamole has been researched along with Endotoxemia in 1 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Endotoxemia: A condition characterized by the presence of ENDOTOXINS in the blood. On lysis, the outer cell wall of gram-negative bacteria enters the systemic circulation and initiates a pathophysiologic cascade of pro-inflammatory mediators.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seven-day oral treatment with dipyridamole increases the circulating adenosine concentration and augments the antiinflammatory response during experimental human endotoxemia, which is associated with a faster decline in proinflammatory cytokines." | 9.15 | Dipyridamole augments the antiinflammatory response during human endotoxemia. ( Heemskerk, S; Peters, WH; Pickkers, P; Ramakers, BP; Riksen, NP; Smits, P; Stal, TH; van den Broek, P; van der Hoeven, JG, 2011) |
| "Seven-day oral treatment with dipyridamole increases the circulating adenosine concentration and augments the antiinflammatory response during experimental human endotoxemia, which is associated with a faster decline in proinflammatory cytokines." | 5.15 | Dipyridamole augments the antiinflammatory response during human endotoxemia. ( Heemskerk, S; Peters, WH; Pickkers, P; Ramakers, BP; Riksen, NP; Smits, P; Stal, TH; van den Broek, P; van der Hoeven, JG, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ramakers, BP | 1 |
| Riksen, NP | 1 |
| Stal, TH | 1 |
| Heemskerk, S | 1 |
| van den Broek, P | 1 |
| Peters, WH | 1 |
| van der Hoeven, JG | 1 |
| Smits, P | 1 |
| Pickkers, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Oral Dipyridamole Treatment on the Innate Immune Response During Human Endotoxemia.[NCT01091571] | Phase 4 | 30 participants (Anticipated) | Interventional | 2010-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for dipyridamole and Endotoxemia
| Article | Year |
|---|---|
Dipyridamole augments the antiinflammatory response during human endotoxemia.
Topics: Acetylcholine; Creatinine; Dipyridamole; Double-Blind Method; Endotoxemia; Endotoxins; Equilibrative | 2011 |