Page last updated: 2024-10-26

dipyridamole and Cardiomyopathy, Dilated

dipyridamole has been researched along with Cardiomyopathy, Dilated in 30 studies

Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Cardiomyopathy, Dilated: A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.

Research Excerpts

ExcerptRelevanceReference
"Absolute regional MBF (milliliters per minute per gram) was measured by positron emission tomography and 13N-ammonia in resting conditions, during pacing-induced tachycardia, and after dipyridamole infusion (0."7.69Myocardial blood flow response to pacing tachycardia and to dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitative assessment by positron emission tomography. ( Gallopin, M; Giorgetti, A; Lunardi, M; Michelassi, C; Neglia, D; Parodi, O; Pelosi, G; Pratali, L; Salvadori, P; Sambuceti, G, 1995)
"We studied 22 patients with IDC and 22 control subjects using PET with nitrogen-13 ammonia to measure myocardial blood flow (MBF) at rest and during dipyridamole-induced hyperemia."3.70Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy. ( Blanksma, PK; Crijns, HJ; Siebelink, HM; Vaalburg, WM; van den Heuvel, AF; van der Wall, EE; van Gilst, WH; van Veldhuisen, DJ, 2000)
"Absolute regional MBF (milliliters per minute per gram) was measured by positron emission tomography and 13N-ammonia in resting conditions, during pacing-induced tachycardia, and after dipyridamole infusion (0."3.69Myocardial blood flow response to pacing tachycardia and to dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitative assessment by positron emission tomography. ( Gallopin, M; Giorgetti, A; Lunardi, M; Michelassi, C; Neglia, D; Parodi, O; Pelosi, G; Pratali, L; Salvadori, P; Sambuceti, G, 1995)
"A method for quantitative determination of the percentage of left ventricular myocardial 201Tl isotope uptake at rest and during dipyridamole test was first used in patients with dilated cardiomyopathy and coronary heart disease complicated by circulatory insufficiency or chronic myocarditis."3.68[The radionuclide diagnosis of dilated cardiomyopathy: a new approach to assessing myocardial perfusion function by 201Tl scintigraphic data at rest and during the performance of the dipyridamole test]. ( Belenkov, IuN; Naumov, VG; Ostroumov, EN; Saidova, MA; Sergienko, VB, 1992)
"Patients with non ischemic-dilated cardiomyopathy (DCM) are characterized by an activation of the adenosinergic system and reduced coronary flow reserve (CFR) evaluated by transthoracic Doppler echocardiography during vasodilator adenosinergic stress (dipyridamole administration)."2.76Adenosine A2(A) receptor gene polymorphism (1976C>T) affects coronary flow reserve response during vasodilator stress testing in patients with non ischemic-dilated cardiomyopathy. ( Andreassi, MG; Borghini, A; Capecchi, PL; Foffa, I; Laghi Pasini, F; Picano, E; Pompella, G; Sicari, R, 2011)
"atheromatous coronary disease, dilated cardiomyopathy, scleroderma, sarcoidosis) and in patients who had undergone heart transplantation."2.37[Coronary reserve: a dynamic evaluation of coronary circulation]. ( Foult, JM; Nitenberg, A, 1987)
"In Idiopathic Dilated Cardiomyopathy (IDC) an imbalance between myocardial oxygen consumption and supply has been postulated."1.36Myocardial perfusion reserve and contractile pattern after beta-blocker therapy in patients with idiopathic dilated cardiomyopathy. ( Dierckx, RA; Lubbers, DD; Slart, RH; Tio, RA; van der Vleuten, PA; van Veldhuisen, DJ; Willems, TP, 2010)
"In a Cox model, mitral insufficiency (hazard ratio [HR] 1."1.34The independent prognostic value of contractile and coronary flow reserve determined by dipyridamole stress echocardiography in patients with idiopathic dilated cardiomyopathy. ( Galderisi, M; Gherardi, S; Picano, E; Rigo, F; Sicari, R, 2007)
"Twenty-six patients with dilated cardiomyopathy and angiographically normal coronary arteries, 12 of whom gave a history of anginal chest pain, underwent noninvasive and invasive hemodynamic study."1.27Dynamic limitation of coronary vasodilator reserve in patients with dilated cardiomyopathy and chest pain. ( Cannon, RO; Cunnion, RE; Epstein, SE; Palmeri, ST; Parrillo, JE; Schenke, WH; Tucker, EE, 1987)
"The dipyridamole test was performed during diagnostic coronaro-ventriculography in 7 patients showing no angiographic signs of coronary atherosclerosis (group 1) and 15 patients with a 75% stenosis in one or more coronary arteries (group 2)."1.27[Changes in segmental and general left ventricular myocardial contractility and intracardiac hemodynamics in the dipyridamole test of patients with ischemic heart disease (data of roentgenocontrast ventriculography)]. ( Koshumbaeva, KM; Samko, AN; Savchenko, AP; Sidorenko, BA, 1986)

Research

Studies (30)

TimeframeStudies, this research(%)All Research%
pre-199010 (33.33)18.7374
1990's7 (23.33)18.2507
2000's8 (26.67)29.6817
2010's5 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Schwartzmann, PV1
Carvalho, EE1
de Figueiredo, AB1
Marin-Neto, JA1
Simões, MV1
Ciampi, Q1
Cortigiani, L2
Pratali, L4
Rigo, F3
Villari, B1
Picano, E7
Sicari, R4
Giannessi, D1
Caselli, C1
Del Ry, S1
Maltinti, M1
Pardini, S1
Turchi, S1
Cabiati, M1
Sampietro, T1
Abraham, N1
L'abbate, A1
Neglia, D2
Slart, RH1
Tio, RA1
van der Vleuten, PA1
Willems, TP1
Lubbers, DD1
Dierckx, RA1
van Veldhuisen, DJ2
Andreassi, MG1
Laghi Pasini, F1
Capecchi, PL2
Pompella, G1
Foffa, I1
Borghini, A1
Laghi-Pasini, F1
Guideri, F1
Petersen, C1
Lazzerini, PE1
Stolen, KQ1
Kemppainen, J1
Kalliokoski, KK1
Karanko, H1
Toikka, J1
Janatuinen, T1
Raitakari, OT1
Airaksinen, KE1
Nuutila, P1
Knuuti, J1
Watzinger, N1
Lund, GK1
Saeed, M1
Reddy, GP1
Araoz, PA1
Yang, M1
Schwartz, AB1
Bedigian, M1
Higgins, CB1
Otasevic, P2
Gherardi, S2
Neskovic, A2
Chinnaiyan, KM1
Trivax, J1
Franklin, BA1
Williamson, B1
Kahn, JK1
Galderisi, M1
Molinaro, S1
Grec, V1
Grbic, M1
Sigwart, U1
Parodi, O1
Gallopin, M1
Sambuceti, G1
Giorgetti, A1
Salvadori, P1
Michelassi, C1
Lunardi, M1
Pelosi, G1
Merlet, P1
Mazoyer, B1
Hittinger, L1
Valette, H1
Saal, JP1
Bendriem, B1
Crozatier, B1
Castaigne, A1
Syrota, A1
Randé, JL1
Weismüller, S1
Czernin, J1
Sun, KT1
Fung, C1
Phelps, ME1
Schelbert, HR1
Kalsi, KK1
Smolenski, RT1
Pritchard, RD1
Khaghani, A1
Seymour, AM1
Yacoub, MH1
Baroni, M1
Palmieri, C1
Boni, A1
Ravani, M1
Biagini, A1
Nannini, E1
van den Heuvel, AF1
van der Wall, EE1
Blanksma, PK1
Siebelink, HM1
Vaalburg, WM1
van Gilst, WH1
Crijns, HJ1
Saidova, MA1
Ostroumov, EN1
Naumov, VG1
Sergienko, VB1
Belenkov, IuN1
Chikamori, T1
Doi, YL1
Yonezawa, Y1
Yamada, M2
Seo, H1
Ozawa, T2
Yabe, T1
Doi, Y1
Yonesawa, Y1
Takada, J1
Odawara, H1
Cannon, RO2
Nitenberg, A2
Foult, JM2
Shiotani, H3
Yamabe, H1
Fukuzaki, H3
Mori, T1
Suda, K1
Ohnishi, M1
Kanoh, Y2
Yokota, Y2
Fujitani, K1
Maeda, K2
Cunnion, RE1
Parrillo, JE1
Palmeri, ST1
Tucker, EE1
Schenke, WH1
Epstein, SE1
Savchenko, AP1
Koshumbaeva, KM1
Sidorenko, BA1
Samko, AN1
Ohmori, Y1
Blanchet, F1
Zouioueche, S1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Quantification of Myocardial Blood Flow by Positron Emission Tomography in Healthy Volunteers[NCT03895554]20 participants (Anticipated)Observational2019-04-01Not yet recruiting
Ammonia N-13 Myocardial Blood Flow Absolute Quantification by Positron Emission Tomography in Patients With Known or Suspected Coronary Artery Disease (Ammonia MAP)[NCT04343209]2,500 participants (Anticipated)Observational2020-09-14Recruiting
Quantification of Myocardial Blood Flow by 3D Positron Emission Tomography With High and Low Rate Rb82 Infusion Profiles[NCT05286593]Phase 498 participants (Actual)Interventional2021-12-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for dipyridamole and Cardiomyopathy, Dilated

ArticleYear
Coronary flow reserve in patients with chest pain, angiographically normal coronary arteries and normal left ventricle, dilated cardiomyopathy, and hypertrophic cardiomyopathy.
    Bibliotheca cardiologica, 1989, Issue:44

    Topics: Angina Pectoris; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Coronary Angiography; Corona

1989
[Coronary reserve: a dynamic evaluation of coronary circulation].
    Archives des maladies du coeur et des vaisseaux, 1987, Volume: 80 Spec No

    Topics: Cardiomyopathy, Dilated; Coronary Circulation; Coronary Disease; Dipyridamole; Heart Diseases; Heart

1987

Trials

1 trial available for dipyridamole and Cardiomyopathy, Dilated

ArticleYear
Adenosine A2(A) receptor gene polymorphism (1976C>T) affects coronary flow reserve response during vasodilator stress testing in patients with non ischemic-dilated cardiomyopathy.
    Pharmacogenetics and genomics, 2011, Volume: 21, Issue:8

    Topics: Adult; Aged; Cardiomyopathy, Dilated; Coronary Circulation; Dipyridamole; Echocardiography, Doppler;

2011

Other Studies

27 other studies available for dipyridamole and Cardiomyopathy, Dilated

ArticleYear
The presence of contractile reserve predicts the left ventricular systolic function improvement after prolonged oral dipyridamole use in patients with non-ischemic dilated cardiomyopathy.
    International journal of cardiology, 2014, Apr-01, Volume: 172, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Aged; Cardiomyopathy, Dilated; Coronary Angiography; Dipyri

2014
Left Bundle Branch Block Negatively Affects Coronary Flow Velocity Reserve and Myocardial Contractile Reserve in Nonischemic Dilated Cardiomyopathy.
    Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2016, Volume: 29, Issue:2

    Topics: Blood Flow Velocity; Bundle-Branch Block; Cardiac Output, Low; Cardiomyopathy, Dilated; Coronary Ang

2016
Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure.
    Metabolism: clinical and experimental, 2011, Volume: 60, Issue:2

    Topics: Adiponectin; Ammonia; Body Mass Index; Cardiomyopathy, Dilated; Cholesterol, HDL; Cohort Studies; Co

2011
Myocardial perfusion reserve and contractile pattern after beta-blocker therapy in patients with idiopathic dilated cardiomyopathy.
    Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2010, Volume: 17, Issue:3

    Topics: Adrenergic beta-Antagonists; Cardiomyopathy, Dilated; Coronary Circulation; Dipyridamole; Female; Fl

2010
Blunted increase in plasma adenosine levels following dipyridamole stress in dilated cardiomyopathy patients.
    Journal of internal medicine, 2003, Volume: 254, Issue:6

    Topics: Adenosine; Aged; Cardiomyopathy, Dilated; Case-Control Studies; Dipyridamole; Echocardiography, Stre

2003
Myocardial perfusion reserve and peripheral endothelial function in patients with idiopathic dilated cardiomyopathy.
    The American journal of cardiology, 2004, Jan-01, Volume: 93, Issue:1

    Topics: Brachial Artery; Cardiomyopathy, Dilated; Case-Control Studies; Coronary Circulation; Dipyridamole;

2004
Myocardial blood flow in patients with dilated cardiomyopathy: quantitative assessment with velocity-encoded cine magnetic resonance imaging of the coronary sinus.
    Journal of magnetic resonance imaging : JMRI, 2005, Volume: 21, Issue:4

    Topics: Adult; Aged; Cardiomyopathy, Dilated; Coronary Circulation; Dipyridamole; Female; Heart Failure; Hum

2005
The additive prognostic value of restrictive pattern and dipyridamole-induced contractile reserve in idiopathic dilated cardiomyopathy.
    European journal of heart failure, 2005, Volume: 7, Issue:5

    Topics: Aged; Cardiomyopathy, Dilated; Dipyridamole; Echocardiography, Stress; Female; Humans; Male; Middle

2005
Stress testing in patients with implantable cardioverter-defibrillators: a preliminary report.
    Preventive cardiology, 2007,Spring, Volume: 10, Issue:2

    Topics: Adrenergic beta-Agonists; Aged; Arrhythmias, Cardiac; Blood Pressure; Cardiomyopathy, Dilated; Defib

2007
The independent prognostic value of contractile and coronary flow reserve determined by dipyridamole stress echocardiography in patients with idiopathic dilated cardiomyopathy.
    The American journal of cardiology, 2007, Apr-15, Volume: 99, Issue:8

    Topics: Blood Flow Velocity; Bundle-Branch Block; Cardiac Output, Low; Cardiomyopathy, Dilated; Coronary Ang

2007
Prognostic value of pharmacologic stress echocardiography in patients with idiopathic dilated cardiomyopathy: a prospective, head-to-head comparison between dipyridamole and dobutamine test.
    Journal of cardiac failure, 2007, Volume: 13, Issue:10

    Topics: Cardiomyopathy, Dilated; Cardiotonic Agents; Dipyridamole; Dobutamine; Echocardiography, Stress; Fem

2007
[Congestive cardiomyopathy: value of short and long-term vasodilator treatment and prognosis].
    Schweizerische medizinische Wochenschrift, 1983, Apr-09, Volume: 113, Issue:14

    Topics: Adult; Aged; Blood Pressure; Cardiomyopathy, Dilated; Dipyridamole; Female; Heart Rate; Humans; Isos

1983
Myocardial blood flow response to pacing tachycardia and to dipyridamole infusion in patients with dilated cardiomyopathy without overt heart failure. A quantitative assessment by positron emission tomography.
    Circulation, 1995, Aug-15, Volume: 92, Issue:4

    Topics: Adult; Aged; Cardiac Output, Low; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Coronary Circ

1995
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Assessment of coronary reserve in man: comparison between positron emission tomography with oxygen-15-labeled water and intracoronary Doppler technique.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1993, Volume: 34, Issue:11

    Topics: Blood Flow Velocity; Blood Pressure; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels

1993
Coronary vasodilatory capacity is impaired in patients with dilated cardiomyopathy.
    American journal of cardiac imaging, 1996, Volume: 10, Issue:3

    Topics: Adult; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Vessels; Dipyridamole; Female; Heart;

1996
Effects of dipyridamole and adenine/ribose on ATP concentration and adenosine production in cardiac myocytes.
    Advances in experimental medicine and biology, 1998, Volume: 431

    Topics: Adenine; Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Cardiomyopathy, Dilated; Cardiomyop

1998
Acute hemodynamic effects of endogenous adenosine in patients with chronic heart failure.
    American heart journal, 1998, Volume: 136, Issue:1

    Topics: Adenosine; Cardiac Catheterization; Cardiomyopathy, Dilated; Chronic Disease; Dipyridamole; Female;

1998
Regional myocardial blood flow reserve impairment and metabolic changes suggesting myocardial ischemia in patients with idiopathic dilated cardiomyopathy.
    Journal of the American College of Cardiology, 2000, Volume: 35, Issue:1

    Topics: Adult; Aged; Cardiomyopathy, Dilated; Coronary Circulation; Dipyridamole; Energy Metabolism; Female;

2000
[The radionuclide diagnosis of dilated cardiomyopathy: a new approach to assessing myocardial perfusion function by 201Tl scintigraphic data at rest and during the performance of the dipyridamole test].
    Kardiologiia, 1992, Volume: 32, Issue:7-8

    Topics: Adolescent; Adult; Aged; Cardiomyopathy, Dilated; Chronic Disease; Dipyridamole; Electrocardiography

1992
Value of dipyridamole thallium-201 imaging in noninvasive differentiation of idiopathic dilated cardiomyopathy from coronary artery disease with left ventricular dysfunction.
    The American journal of cardiology, 1992, Mar-01, Volume: 69, Issue:6

    Topics: Adult; Aged; Cardiomyopathy, Dilated; Chi-Square Distribution; Coronary Disease; Diagnosis, Differen

1992
[Assessment of prognosis of patients with ventricular tachycardia: role of the underlying heart disease].
    Journal of cardiology. Supplement, 1989, Volume: 22

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cardiac Catheterization; Cardiomyopathy, Dilated; Cardio

1989
The clinical and prognostic significance of dipyridamole Tl-201 emission computed tomography in patients with dilated cardiomyopathy.
    Japanese circulation journal, 1987, Volume: 51, Issue:9

    Topics: Aged; Cardiomyopathy, Dilated; Dipyridamole; Echocardiography; Female; Humans; Male; Middle Aged; Pr

1987
[Hypertrophic non-obstructive cardiomyopathy assessed by dipyridamole thallium single photon emission computed tomography: comparisons with hypertrophic cardiomyopathy with a dilated heart].
    Journal of cardiology, 1987, Volume: 17, Issue:1

    Topics: Adult; Aged; Cardiac Catheterization; Cardiomyopathy, Dilated; Cardiomyopathy, Hypertrophic; Dipyrid

1987
Dynamic limitation of coronary vasodilator reserve in patients with dilated cardiomyopathy and chest pain.
    Journal of the American College of Cardiology, 1987, Volume: 10, Issue:6

    Topics: Adult; Angina Pectoris; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Coronary Circulation; D

1987
[Changes in segmental and general left ventricular myocardial contractility and intracardiac hemodynamics in the dipyridamole test of patients with ischemic heart disease (data of roentgenocontrast ventriculography)].
    Kardiologiia, 1986, Volume: 26, Issue:10

    Topics: Adult; Cardiomyopathy, Dilated; Coronary Circulation; Coronary Disease; Dipyridamole; Female; Heart

1986
[201T1 computed tomography using dipyridamole for assessing dilated cardiomyopathy].
    Journal of cardiography, 1985, Volume: 15, Issue:4

    Topics: Cardiomyopathy, Dilated; Coronary Circulation; Dipyridamole; Female; Humans; Male; Middle Aged; Myoc

1985
Multifactorial determinants of reduced coronary flow reserve after dipyridamole in dilated cardiomyopathy.
    The American journal of cardiology, 1985, Mar-01, Volume: 55, Issue:6

    Topics: Adult; Blood Flow Velocity; Blood Pressure; Cardiac Catheterization; Cardiomyopathy, Dilated; Corona

1985