dipyridamole has been researched along with Carcinoma, Hepatocellular in 18 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, however, changes in intracellular cyclic AMP level in several lines of cultured cells (normal 3T3 and SV40 and polyomavirus-transformed 3T3 cells; 3T6, C6 GLIOMA, MOUSE L, and Novikoff rat hepatoma cells) by treatment with papaverine, prostaglandine E1 or isoproterenol did not correlate with the inhibition of the uridine, hypoxanthine or deoxyglucose transport rates by these chemicals." | 3.65 | Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells. ( Plagemann, PG; Sheppard, JR, 1975) |
| " In mouse hepatoma H22 model, the triple drug combination showed synergistic and highly potent antitumor efficacy." | 1.40 | A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice. ( Li, Y; Liu, XJ; Wu, SY; Zhen, YS; Zheng, YB, 2014) |
| "Novikoff rat hepatoma cells were propagated in suspension culture in the presence of 1 micron methotrexate and various concentrations of hypoxanthine (or adenosine plus guanosine) and thymidine and with or without the inhibitor of nucleoside and purine transport, Persantin (dipyridamole)." | 1.26 | Growth rate of cultured Novikoff rat hepatoma cells as a function of the rate of thymidine and hypoxanthine transport. ( Marz, R; Plagemann, PG; Wohlhueter, RM, 1977) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (72.22) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 3 (16.67) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rius, M | 1 |
| Nies, AT | 1 |
| Hummel-Eisenbeiss, J | 1 |
| Jedlitschky, G | 1 |
| Keppler, D | 1 |
| Liu, XJ | 1 |
| Zheng, YB | 1 |
| Li, Y | 1 |
| Wu, SY | 1 |
| Zhen, YS | 1 |
| Wen, LT | 1 |
| Knowles, AF | 1 |
| Wu, LF | 1 |
| Li, GP | 1 |
| Feng, JL | 1 |
| Pu, ZJ | 1 |
| Sheppard, JR | 1 |
| Plagemann, PG | 12 |
| Zylka, JM | 1 |
| Behrens, M | 1 |
| Marz, R | 1 |
| Wohlhueter, RM | 1 |
| Tatsuta, T | 1 |
| Shimizu, K | 1 |
| Nishimura, T | 1 |
| Suzuki, H | 1 |
| Schmähl, D | 1 |
| Stackelberg, S | 1 |
| Roth, MF | 1 |
| Renner, ED | 1 |
| Bernlohr, RW | 1 |
| Erbe, J | 4 |
| Richey, DP | 1 |
1 review available for dipyridamole and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Transport of nucleosides, nucleic acid bases, choline and glucose by animal cells in culture.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Division; Cell Membrane; Cell Transfo | 1974 |
17 other studies available for dipyridamole and Carcinoma, Hepatocellular
| Article | Year |
|---|---|
Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Animals; Antibodies; Carcinoma, Hepatocellular; Cell Po | 2003 |
A multifunctional drug combination shows highly potent therapeutic efficacy against human cancer xenografts in athymic mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Wester | 2014 |
Extracellular ATP and adenosine induce cell apoptosis of human hepatoma Li-7A cells via the A3 adenosine receptor.
Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Diphosphate; Adenosine Monophosphate; | 2003 |
Molecular mechanisms of adenosine-induced apoptosis in human HepG2 cells.
Topics: Adenosine; Apoptosis; Carcinoma, Hepatocellular; Caspase 3; Caspases; Cell Line, Tumor; Cell Prolife | 2006 |
Cyclic AMP, membrane transport and cell division. I. Effects of various chemicals on cyclic AMP levels and rate of transport of neucleosides, hypoxanthine and deoxyglucose in several lines of cultured cells.
Topics: Animals; Biological Transport, Active; Bucladesine; Carcinoma, Hepatocellular; Cell Division; Cell L | 1975 |
Purine and pyrimidine transport by cultured Novikoff cells. Specificities and mechanism of transport and relationship to phosphoribosylation.
Topics: Adenine; Animals; Biological Transport, Active; Calorimetry; Carcinoma, Hepatocellular; Cell Line; C | 1975 |
Inhibition of de novo pyrimidine nucleotide and DNA synthesis and growth of cultured Novikoff rat hepatoma cells and other cell lines by pyrazofurin (NSC 143095).
Topics: Adenosine; Amides; Anti-Bacterial Agents; Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; | 1976 |
Growth rate of cultured Novikoff rat hepatoma cells as a function of the rate of thymidine and hypoxanthine transport.
Topics: Adenosine; Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Survival; Cells, Cultured; | 1977 |
Enhancement of activities of anti-tumor drugs by dipyridamole against multidrug-resistant human hepatoma PLC/PRF/5 cells.
Topics: Affinity Labels; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Bio | 1991 |
[The effect of lactoflavin, nicotinic acid amide or dipyridamol on the cancerogenic action of diethylnitrosamine in rats].
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Dipyridamole; Female; Kidney; Liver; Liver Neoplasm | 1968 |
Permeation as the rate-limiting step in the phosphorylation of uridine and choline and their incorporation into macromolecules by Novikoff hepatoma cells. Competitive inhibition by phenethyl alcohol, persantin, and adenosine.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane Permeability; Cel | 1969 |
Nucleoside transport by Novikoff rat hepatoma cells glowing in suspension culture. Specificity and mechanism of transport reactions and relationship to nucleoside incorporation into nucleic acids.
Topics: Adenosine; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Chloromercur | 1971 |
Permeation of glucose by simple and facilitated diffusion by Novikoff rat hepatoma cells in suspension culture and its relationship to glucose metabolism.
Topics: Animals; Biological Transport; Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Frac | 1972 |
Thymidine transport by cultured Novikoff hepatoma cells and uptake by simple diffusion and relationship to incorporation into deoxyribonucleic acid.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell-Free System; Chloromercuri | 1972 |
Transport and metabolism of glucosamine by cultured Novikoff rat hepatoma cells and effects on nucleotide pools.
Topics: Adenine Nucleotides; Adenosine; Animals; Biological Transport; Carbon Dioxide; Carbon Isotopes; Carc | 1973 |
Intracellular conversions of deoxyribonucleosides by Novikoff rat hepatoma cells and effects of hydroxyurea.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Cells, Cultured; Cycloheximide; Cytidine; Deamination | 1974 |
The deoxyribonucleoside transport systems of cultured Novikoff rat hepatoma cells.
Topics: Animals; Biological Transport; Carcinoma, Hepatocellular; Cell Line; Cell Membrane Permeability; Cel | 1974 |