dipyridamole has been researched along with Cancer of Colon in 21 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deoxyuridine monophosphate levels were greatly increased when cells were exposed to 5-FU alone, and were even larger with the addition of dipyridamole." | 2.38 | Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience. ( Grem, JL, 1992) |
| "Determined by clonogenic assay in human colon cancer HT-29 cells, the cell survivals for AZT, 10 microM, dipyridamole, 5 microM, and methotrexate (MTX), 0." | 1.28 | Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells. ( Taniki, T; Weber, G; Zhen, YS, 1992) |
| "In HCT 116 cells, a human colon cancer cell line, the levels of thymidine (0." | 1.27 | Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole. ( Fischer, PH; Pangallo, CA; Van Mouwerik, TJ; Willson, JK, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (42.86) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 3 (14.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
| Authors | Studies |
|---|---|
| Zhou, S | 1 |
| Xu, H | 1 |
| Tang, Q | 1 |
| Xia, H | 1 |
| Bi, F | 1 |
| Goda, AE | 1 |
| Yoshida, T | 1 |
| Horinaka, M | 1 |
| Yasuda, T | 1 |
| Shiraishi, T | 1 |
| Wakada, M | 1 |
| Sakai, T | 1 |
| Fischer, PH | 5 |
| Pamukcu, R | 1 |
| Bittner, G | 1 |
| Willson, JK | 2 |
| Camici, M | 2 |
| Turriani, M | 2 |
| Tozzi, MG | 2 |
| Turchi, G | 2 |
| Cos, J | 2 |
| Alemany, C | 2 |
| Miralles, A | 1 |
| Noe, V | 2 |
| Ciudad, CJ | 2 |
| Berti, E | 1 |
| Carrara, M | 1 |
| Ragazzi, E | 1 |
| D'Ancona, S | 1 |
| Berti, T | 1 |
| Krishan, A | 1 |
| Sridhar, KS | 1 |
| Mou, C | 1 |
| Stein, WD | 1 |
| Lyubimov, E | 1 |
| Hu, YP | 1 |
| Fernandez, H | 1 |
| Boyer, CR | 1 |
| Karjian, PL | 1 |
| Wahl, GM | 1 |
| Pegram, M | 1 |
| Neuteboom, ST | 1 |
| Grem, JL | 4 |
| Zhen, YS | 1 |
| Taniki, T | 1 |
| Weber, G | 1 |
| Kikkawa, N | 1 |
| Kato, T | 1 |
| Iwanaga, T | 1 |
| Utsunomiya, J | 1 |
| Hioki, K | 1 |
| Mori, T | 1 |
| Yasutomi, M | 1 |
| Fukuda, I | 1 |
| Kameyama, M | 1 |
| Lawrence, TS | 1 |
| Heimburger, DK | 1 |
| Shewach, DS | 1 |
| Schmoll, HJ | 1 |
| Harstrick, A | 1 |
| Köhne-Wömpner, CH | 1 |
| Schöber, C | 1 |
| Wilke, H | 1 |
| Poliwoda, H | 1 |
| Mulcahy, RT | 1 |
| Miller, EM | 1 |
| Allegra, CJ | 1 |
| Lönn, U | 1 |
| Lönn, S | 1 |
| Nylen, U | 1 |
| Winblad, G | 1 |
| Gaffen, JD | 1 |
| Chambers, EA | 1 |
| Bennett, A | 1 |
| Van Mouwerik, TJ | 1 |
| Pangallo, CA | 1 |
| Wadler, S | 1 |
| Subar, M | 1 |
| Green, MD | 1 |
| Wiernik, PH | 1 |
| Muggia, FM | 1 |
| Chan, TC | 1 |
| Young, B | 1 |
| King, ME | 1 |
| Taetle, R | 1 |
| Howell, SB | 1 |
2 reviews available for dipyridamole and Cancer of Colon
| Article | Year |
|---|---|
Biochemical modulation of fluorouracil by dipyridamole: preclinical and clinical experience.
Topics: Colonic Neoplasms; Deoxyuridine; Dipyridamole; DNA Damage; DNA, Neoplasm; Drug Interactions; Fluorou | 1992 |
Modulation of cytotoxic drug activity by dipyridamole.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; | 1990 |
1 trial available for dipyridamole and Cancer of Colon
| Article | Year |
|---|---|
Synergistic effect of prochlorperazine and dipyridamole on the cellular retention and cytotoxicity of doxorubicin.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Cell Survival; Colonic Neoplasms; Culture Media; D | 2000 |
18 other studies available for dipyridamole and Cancer of Colon
| Article | Year |
|---|---|
Dipyridamole Enhances the Cytotoxicities of Trametinib against Colon Cancer Cells through Combined Targeting of HMGCS1 and MEK Pathway.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Dipyridamole; Female; Humans; Hydr | 2020 |
Mechanisms of enhancement of TRAIL tumoricidal activity against human cancer cells of different origin by dipyridamole.
Topics: Apoptosis; Blotting, Northern; Bone Neoplasms; Colonic Neoplasms; Cyclic AMP-Dependent Protein Kinas | 2008 |
Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.
Topics: Antibiotics, Antineoplastic; Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; | 1984 |
Purine enzyme profile in human colon-carcinoma cell lines and differential sensitivity to deoxycoformycin and 2'-deoxyadenosine in combination.
Topics: Adenosine Kinase; Antimetabolites, Antineoplastic; Cell Division; Colonic Neoplasms; Deoxyadenosines | 1995 |
Cytotoxicity of deoxycoformycin on human colon carcinoma cell lines.
Topics: 5'-Nucleotidase; Adamantane; Adenosine Deaminase; Adenosine Kinase; Adenosine Monophosphate; AMP Dea | 1994 |
A comparison of the modulation of antiblastics cytotoxicity by verapamil and dipyridamole in a human colon carcinoma cell line.
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Antineoplastic Agents; ATP Binding Cassette Transporter | 1999 |
Nucleoside transport inhibitors, dipyridamole and p-nitrobenzylthioinosine, selectively potentiate the antitumor activity of NB1011.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Bromodeoxyuridine; Carrier | 2002 |
Azidothymidine and dipyridamole as biochemical response modifiers: synergism with methotrexate and 5-fluorouracil in human colon and pancreatic carcinoma cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; DNA Replic | 1992 |
[Potentiation of thymidylate synthetase (TS) inhibition by combined administration of HCFU and dipyridamole: preliminary report. Kinki Cooperative Study Group of Chemotherapy for Colorectal Carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Dipyridamole; Female; Fluor | 1992 |
The effects of leucovorin and dipyridamole on fluoropyrimidine-induced radiosensitization.
Topics: Adenocarcinoma; Colonic Neoplasms; Combined Modality Therapy; Dipyridamole; DNA Repair; DNA, Neoplas | 1991 |
Interaction of deoxyuridine with fluorouracil and dipyridamole in a human colon cancer cell line.
Topics: Cell Survival; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; DNA Dama | 1989 |
5-Fluoropyrimidine-induced DNA damage in human colon adenocarcinoma and its augmentation by the nucleoside transport inhibitor dipyridamole.
Topics: Adenocarcinoma; Colonic Neoplasms; Dipyridamole; DNA; DNA Damage; Floxuridine; Fluorouracil; Humans; | 1989 |
The effects of dipyridamole and indomethacin on methotrexate cytotoxicity in LoVo human colon cancer cells.
Topics: Cell Division; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Indomethacin; Methotrexate; T | 1989 |
Alteration of fluorouracil metabolism in human colon cancer cells by dipyridamole with a selective increase in fluorodeoxyuridine monophosphate levels.
Topics: Cells, Cultured; Colonic Neoplasms; Deoxyuracil Nucleotides; Deoxyuridine; Dipyridamole; DNA; Floxur | 1986 |
Augmentation of methotrexate cytotoxicity in human colon cancer cells achieved through inhibition of thymidine salvage by dipyridamole.
Topics: Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Drug Synergism; Guanine; Humans; Hypoxant | 1987 |
Phase II trial of oral methotrexate and dipyridamole in colorectal carcinoma.
Topics: Adenocarcinoma; Administration, Oral; Aged; Colonic Neoplasms; Dipyridamole; Drug Evaluation; Drug T | 1987 |
Modulation of the activity of PALA by dipyridamole.
Topics: Animals; Aspartic Acid; Biological Transport; Cell Line; Colonic Neoplasms; Dipyridamole; Drug Inter | 1985 |
Augmentation of 5-fluorouracil cytotoxicity in human colon cancer cells by dipyridamole.
Topics: Cell Division; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Dose-Response Relationship | 1985 |