dipyridamole has been researched along with Bilateral Headache in 27 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA)." | 9.51 | Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial. ( Cha, JK; Chang, DI; Chang, JY; Chung, JW; Hong, KS; Jung, KH; Kang, MK; Kim, BK; Kim, HY; Lee, KY; Lee, SJ; Park, JM; Park, MS; Rha, JH; Shin, DI; Yoon, BW, 2022) |
| "We showed that slower than standard dose escalation of dipyridamole in combination therapy with acetylsalicylic acid does not reduce headaches as a side effect." | 9.19 | The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE). ( de Vogel, EM; de Vos-Koppelaar, NC; Dieleman, HG; Kerkhoff, H; Zock, E, 2014) |
| "Secondary pharmacological prevention of ischemic stroke or transient ischemic attack (TIA) is often provided with acetylsalicylic acid (ASA), dipyridamole (DP) or a combination of the two." | 9.14 | Dipyridamole-associated headache in stroke patients--interindividual differences? ( Lökk, J, 2009) |
| "Combination of low-dose aspirin and modified-release dipyridamole (ASA+MR-DP) provides a significantly increased benefit in stroke prevention over aspirin alone." | 9.12 | Dose titration to reduce dipyridamole-related headache. ( Chang, YJ; Lee, TH; Ryu, SJ, 2006) |
| "Headache is reported by about one third of patients using dipyridamole (DP) after stroke or TIA." | 9.11 | Dipyridamole and headache--a pilot study of initial dose titration. ( Husted, S; Lindgren, A; Staaf, G; Ziegler, B, 2004) |
| "The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches." | 9.11 | Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004) |
| "In the Second European Stroke Prevention Study headaches associated with dipyridamole frequently (8% of patients taking dipyridamole or dipyridamole plus acetylsalicylic acid (ASA) vs 2% of patients taking ASA or placebo) led to discontinuation of therapy." | 9.09 | Rapid development of tolerance to dipyridamole-associated headaches. ( Deichsel, G; Marshall, S; Theis, JG, 1999) |
| "Our objective was to investigate the association between recurrent stroke risk and headache induced by extended-release dipyridamole (ER-DP) when administered alone or with low-dose aspirin (ASA+ER-DP)." | 7.80 | Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. ( Bath, PM; Cotton, D; Davidai, G; Diener, HC; Gorelick, P; Lipton, RB; Sacco, R, 2014) |
| "A considerable proportion of patients discontinue dipyridamole therapy because of headache." | 7.75 | Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. ( Algra, A; Halkes, PH; Kappelle, LJ; Koudstaal, PJ; van Gijn, J, 2009) |
| "The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA)." | 5.51 | Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial. ( Cha, JK; Chang, DI; Chang, JY; Chung, JW; Hong, KS; Jung, KH; Kang, MK; Kim, BK; Kim, HY; Lee, KY; Lee, SJ; Park, JM; Park, MS; Rha, JH; Shin, DI; Yoon, BW, 2022) |
| "We showed that slower than standard dose escalation of dipyridamole in combination therapy with acetylsalicylic acid does not reduce headaches as a side effect." | 5.19 | The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE). ( de Vogel, EM; de Vos-Koppelaar, NC; Dieleman, HG; Kerkhoff, H; Zock, E, 2014) |
| "Secondary pharmacological prevention of ischemic stroke or transient ischemic attack (TIA) is often provided with acetylsalicylic acid (ASA), dipyridamole (DP) or a combination of the two." | 5.14 | Dipyridamole-associated headache in stroke patients--interindividual differences? ( Lökk, J, 2009) |
| "Combination of low-dose aspirin and modified-release dipyridamole (ASA+MR-DP) provides a significantly increased benefit in stroke prevention over aspirin alone." | 5.12 | Dose titration to reduce dipyridamole-related headache. ( Chang, YJ; Lee, TH; Ryu, SJ, 2006) |
| "Headache is reported by about one third of patients using dipyridamole (DP) after stroke or TIA." | 5.11 | Dipyridamole and headache--a pilot study of initial dose titration. ( Husted, S; Lindgren, A; Staaf, G; Ziegler, B, 2004) |
| "The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches." | 5.11 | Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004) |
| "In the Second European Stroke Prevention Study headaches associated with dipyridamole frequently (8% of patients taking dipyridamole or dipyridamole plus acetylsalicylic acid (ASA) vs 2% of patients taking ASA or placebo) led to discontinuation of therapy." | 5.09 | Rapid development of tolerance to dipyridamole-associated headaches. ( Deichsel, G; Marshall, S; Theis, JG, 1999) |
| "Our objective was to investigate the association between recurrent stroke risk and headache induced by extended-release dipyridamole (ER-DP) when administered alone or with low-dose aspirin (ASA+ER-DP)." | 3.80 | Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. ( Bath, PM; Cotton, D; Davidai, G; Diener, HC; Gorelick, P; Lipton, RB; Sacco, R, 2014) |
| "A considerable proportion of patients discontinue dipyridamole therapy because of headache." | 3.75 | Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. ( Algra, A; Halkes, PH; Kappelle, LJ; Koudstaal, PJ; van Gijn, J, 2009) |
| "In the Prevention Regimen for Effectively Avoiding Second Strokes (PROFESS) trial, the combination of acetylsalicylic acid (50 mg) and extended-release dipyridamole (400 mg) (ASA+Dip) was compared with clopidogrel (75 mg) in patients with a recent transient ischaemic attack (TIA) or minor disabling stroke." | 3.74 | [Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial]. ( Kappelle, LJ, 2008) |
| "An adverse reaction scale characterizing common noncardiac side effects of dipyridamole in nuclear medicine cardiac patients demonstrated the most prevalent adverse reaction was headache." | 3.71 | Adverse reactions to dipyridamole in patients undergoing stress/rest cardiac perfusion testing. ( Ballow, J; Meyers, AM; Topham, L; Totah, D; Wilke, R, 2002) |
| "In man, intravenous infusion of adenosine has been useful in inducing sustained hypotension during anesthesia." | 3.67 | Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole. ( Biaggioni, I; Hollister, AS; Onrot, J; Robertson, D, 1986) |
| "Dipyridamole was associated with a slight increase in headache, which resolved in most patients if therapy was continued." | 2.69 | Secondary stroke prevention with low-dose aspirin, sustained release dipyridamole alone and in combination. ESPS Investigators. European Stroke Prevention Study. ( Forbes, CD, 1998) |
| "Bleeding is potentially the most significant antiplatelet-associated side effect." | 2.47 | Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events. ( Guthrie, R, 2011) |
| " Use of parenteral aminophylline to treat adverse events associated with intravenous dipyridamole brought complete relief of symptoms in 439 of 454 patients (96." | 1.28 | The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group. ( Kempthorne-Rawson, J; Ranhosky, A, 1990) |
| "Dyspnea was noted in 80 cases (40." | 1.27 | [How dangerous is the dipyridamole test?]. ( Bramann, HU; Görtz, P; Grosse-Heitmeyer, W; Mönninghoff, W; Most, E; St Müller, U, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (29.63) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 9 (33.33) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Kang, MK | 1 |
| Cha, JK | 1 |
| Chang, DI | 1 |
| Kim, HY | 1 |
| Chung, JW | 1 |
| Jung, KH | 1 |
| Hong, KS | 1 |
| Chang, JY | 1 |
| Rha, JH | 1 |
| Park, JM | 1 |
| Kim, BK | 1 |
| Lee, SJ | 1 |
| Park, MS | 1 |
| Lee, KY | 1 |
| Shin, DI | 1 |
| Yoon, BW | 1 |
| de Vos-Koppelaar, NC | 1 |
| Kerkhoff, H | 1 |
| de Vogel, EM | 1 |
| Zock, E | 1 |
| Dieleman, HG | 1 |
| Davidai, G | 2 |
| Cotton, D | 1 |
| Gorelick, P | 1 |
| Bath, PM | 1 |
| Lipton, RB | 2 |
| Sacco, R | 1 |
| Diener, HC | 1 |
| Kappelle, LJ | 2 |
| Halkes, PH | 1 |
| van Gijn, J | 1 |
| Koudstaal, PJ | 1 |
| Algra, A | 1 |
| Lökk, J | 1 |
| Guthrie, R | 1 |
| Lindgren, A | 1 |
| Husted, S | 1 |
| Staaf, G | 1 |
| Ziegler, B | 1 |
| Bigal, ME | 1 |
| Kolodner, KB | 1 |
| Gorelick, PB | 1 |
| Wilks, K | 1 |
| Schoebelock, M | 1 |
| Chang, YJ | 1 |
| Ryu, SJ | 1 |
| Lee, TH | 1 |
| Schrama, E | 1 |
| Eusman, JP | 1 |
| Grosse-Heitmeyer, W | 1 |
| Bramann, HU | 1 |
| Görtz, P | 1 |
| Mönninghoff, W | 1 |
| St Müller, U | 1 |
| Most, E | 1 |
| Diamond, S | 1 |
| Medina, JL | 1 |
| Köhne, CH | 1 |
| Hiddemann, W | 1 |
| Schüller, J | 1 |
| Weiss, J | 1 |
| Lohrmann, HP | 1 |
| Schmitz-Hübner, U | 1 |
| Bodenstein, H | 1 |
| Schöber, C | 1 |
| Wilke, H | 1 |
| Grem, J | 1 |
| Olatidoye, AG | 1 |
| Baltazar, RF | 1 |
| Forbes, CD | 2 |
| Theis, JG | 1 |
| Deichsel, G | 1 |
| Marshall, S | 1 |
| Kruuse, C | 1 |
| Jacobsen, TB | 1 |
| Lassen, LH | 1 |
| Thomsen, LL | 1 |
| Hasselbalch, SG | 1 |
| Dige-Petersen, H | 1 |
| Olesen, J | 1 |
| Meyers, AM | 1 |
| Topham, L | 1 |
| Ballow, J | 1 |
| Totah, D | 1 |
| Wilke, R | 1 |
| Hawkes, CH | 1 |
| Ranhosky, A | 1 |
| Kempthorne-Rawson, J | 1 |
| Biaggioni, I | 1 |
| Onrot, J | 1 |
| Hollister, AS | 1 |
| Robertson, D | 1 |
| Markman, M | 1 |
| Chan, TC | 1 |
| Cleary, S | 1 |
| Howell, SB | 1 |
| Vogel, G | 1 |
| Krusch, G | 1 |
| Acheson, J | 1 |
| Danta, G | 1 |
| Hutchinson, EC | 1 |
| Sempere Leonarte, J | 1 |
1 review available for dipyridamole and Bilateral Headache
| Article | Year |
|---|---|
Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events.
Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Headache; Hemorrhage; Humans; Ischemi | 2011 |
13 trials available for dipyridamole and Bilateral Headache
| Article | Year |
|---|---|
Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial.
Topics: Aspirin; Dipyridamole; Double-Blind Method; Drug Therapy, Combination; Headache; Humans; Ischemic At | 2022 |
The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE).
Topics: Aspirin; Dipyridamole; Drug Therapy, Combination; Female; Headache; Humans; Ischemic Attack, Transie | 2014 |
Dipyridamole-associated headache in stroke patients--interindividual differences?
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Dipyridamole; Drug Therapy, Combination; Femal | 2009 |
Dipyridamole and headache--a pilot study of initial dose titration.
Topics: Aged; Aspirin; Dipyridamole; Drug Therapy, Combination; Female; Follow-Up Studies; Headache; Humans; | 2004 |
Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Dipyridamole; Drug Combinations; Female; Hea | 2004 |
Dose titration to reduce dipyridamole-related headache.
Topics: Aged; Aspirin; Dipyridamole; Drug Administration Schedule; Drug Therapy, Combination; Female; Headac | 2006 |
Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neopla | 1995 |
European stroke prevention study 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke.
Topics: Aged; Aspirin; Cerebrovascular Disorders; Dipyridamole; Disease-Free Survival; Double-Blind Method; | 1997 |
Secondary stroke prevention with low-dose aspirin, sustained release dipyridamole alone and in combination. ESPS Investigators. European Stroke Prevention Study.
Topics: Aged; Aspirin; Cerebrovascular Disorders; Delayed-Action Preparations; Dipyridamole; Disease-Free Su | 1998 |
Rapid development of tolerance to dipyridamole-associated headaches.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Dipyridamole; Double-Bl | 1999 |
Dipyridamole dilates large cerebral arteries concomitant to headache induction in healthy subjects.
Topics: Adolescent; Adult; Cerebral Arteries; Dipyridamole; Female; Headache; Humans; Infusions, Intravenous | 2000 |
Dipyridamole in migraine.
Topics: Clinical Trials as Topic; Dipyridamole; Headache; Humans; Migraine Disorders | 1978 |
Controlled trial of dipyridamole in cerebral vascular disease.
Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Dipyridamole; Female; Headache; Humans; Ischemi | 1969 |
13 other studies available for dipyridamole and Bilateral Headache
| Article | Year |
|---|---|
Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis.
Topics: Aged; Aspirin; Brain Ischemia; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination; | 2014 |
[Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial].
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Aspirin; Benzimida | 2008 |
Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin.
Topics: Aged; Aspirin; Brain Ischemia; Cerebral Arteries; Dipyridamole; Drug Therapy, Combination; Female; H | 2009 |
[The combination of acetylsalicylic acid and dipyridamole is more effective in secondary prevention following transient ischaemic attack or cerebral infarction: the debate is closed].
Topics: Aspirin; Cerebral Infarction; Dipyridamole; Headache; Humans; Ischemic Attack, Transient; Platelet A | 2006 |
[How dangerous is the dipyridamole test?].
Topics: Adult; Aged; Aminophylline; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Cardiac Complexes | 1983 |
Newer drug therapies for headache.
Topics: Antidepressive Agents; Aspirin; Bromocriptine; Clonidine; Cluster Headache; Dipyridamole; Headache; | 1980 |
Dipyridamole-thallium stress testing: a local community hospital experience.
Topics: Aged; Aged, 80 and over; Clinical Protocols; Coronary Disease; Dipyridamole; Dyspnea; Electrocardiog | 1993 |
Adverse reactions to dipyridamole in patients undergoing stress/rest cardiac perfusion testing.
Topics: Chest Pain; Coronary Disease; Dipyridamole; Exercise Test; Female; Headache; Heart; Humans; Male; Na | 2002 |
The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group.
Topics: Adult; Aged; Aminophylline; Bronchial Spasm; Chest Pain; Dipyridamole; Female; Headache; Heart; Hemo | 1990 |
Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole.
Topics: Adenosine; Anti-Arrhythmia Agents; Blood Pressure; Cardiovascular System; Dipyridamole; Dose-Respons | 1986 |
Phase I trial of combination therapy of cancer with N-phosphonacetyl-L-aspartic acid and dipyridamole.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dipyr | 1987 |
[The effect of various drugs in clinical use on thrombocyte functions].
Topics: Adolescent; Adult; Aged; Aminobenzoates; Aminocaproates; Arthritis, Rheumatoid; Aspirin; Blood Coagu | 1969 |
[Contribution to the study of the treatment of headache. Prevention of attacks with dipyridamole].
Topics: Adolescent; Adult; Child; Dipyridamole; Female; Headache; Humans; Male | 1965 |