Page last updated: 2024-10-26

dipyridamole and Bilateral Headache

dipyridamole has been researched along with Bilateral Headache in 27 studies

Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Research Excerpts

ExcerptRelevanceReference
"The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA)."9.51Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial. ( Cha, JK; Chang, DI; Chang, JY; Chung, JW; Hong, KS; Jung, KH; Kang, MK; Kim, BK; Kim, HY; Lee, KY; Lee, SJ; Park, JM; Park, MS; Rha, JH; Shin, DI; Yoon, BW, 2022)
"We showed that slower than standard dose escalation of dipyridamole in combination therapy with acetylsalicylic acid does not reduce headaches as a side effect."9.19The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE). ( de Vogel, EM; de Vos-Koppelaar, NC; Dieleman, HG; Kerkhoff, H; Zock, E, 2014)
"Secondary pharmacological prevention of ischemic stroke or transient ischemic attack (TIA) is often provided with acetylsalicylic acid (ASA), dipyridamole (DP) or a combination of the two."9.14Dipyridamole-associated headache in stroke patients--interindividual differences? ( Lökk, J, 2009)
"Combination of low-dose aspirin and modified-release dipyridamole (ASA+MR-DP) provides a significantly increased benefit in stroke prevention over aspirin alone."9.12Dose titration to reduce dipyridamole-related headache. ( Chang, YJ; Lee, TH; Ryu, SJ, 2006)
"Headache is reported by about one third of patients using dipyridamole (DP) after stroke or TIA."9.11Dipyridamole and headache--a pilot study of initial dose titration. ( Husted, S; Lindgren, A; Staaf, G; Ziegler, B, 2004)
"The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches."9.11Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004)
"In the Second European Stroke Prevention Study headaches associated with dipyridamole frequently (8% of patients taking dipyridamole or dipyridamole plus acetylsalicylic acid (ASA) vs 2% of patients taking ASA or placebo) led to discontinuation of therapy."9.09Rapid development of tolerance to dipyridamole-associated headaches. ( Deichsel, G; Marshall, S; Theis, JG, 1999)
"Our objective was to investigate the association between recurrent stroke risk and headache induced by extended-release dipyridamole (ER-DP) when administered alone or with low-dose aspirin (ASA+ER-DP)."7.80Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. ( Bath, PM; Cotton, D; Davidai, G; Diener, HC; Gorelick, P; Lipton, RB; Sacco, R, 2014)
"A considerable proportion of patients discontinue dipyridamole therapy because of headache."7.75Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. ( Algra, A; Halkes, PH; Kappelle, LJ; Koudstaal, PJ; van Gijn, J, 2009)
"The aim of this study is to investigate the effect of gradual dipyridamole titration and the incidence of dipyridamole-induced headache in patients with ischemic stroke or transient ischemic attack (TIA)."5.51Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial. ( Cha, JK; Chang, DI; Chang, JY; Chung, JW; Hong, KS; Jung, KH; Kang, MK; Kim, BK; Kim, HY; Lee, KY; Lee, SJ; Park, JM; Park, MS; Rha, JH; Shin, DI; Yoon, BW, 2022)
"We showed that slower than standard dose escalation of dipyridamole in combination therapy with acetylsalicylic acid does not reduce headaches as a side effect."5.19The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE). ( de Vogel, EM; de Vos-Koppelaar, NC; Dieleman, HG; Kerkhoff, H; Zock, E, 2014)
"Secondary pharmacological prevention of ischemic stroke or transient ischemic attack (TIA) is often provided with acetylsalicylic acid (ASA), dipyridamole (DP) or a combination of the two."5.14Dipyridamole-associated headache in stroke patients--interindividual differences? ( Lökk, J, 2009)
"Combination of low-dose aspirin and modified-release dipyridamole (ASA+MR-DP) provides a significantly increased benefit in stroke prevention over aspirin alone."5.12Dose titration to reduce dipyridamole-related headache. ( Chang, YJ; Lee, TH; Ryu, SJ, 2006)
"Headache is reported by about one third of patients using dipyridamole (DP) after stroke or TIA."5.11Dipyridamole and headache--a pilot study of initial dose titration. ( Husted, S; Lindgren, A; Staaf, G; Ziegler, B, 2004)
"The authors assessed the prevalence of headaches following extended-release dipyridamole/aspirin combination (DAC), and the efficacy of acetaminophen in the treatment of these headaches."5.11Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination. ( Bigal, ME; Davidai, G; Gorelick, PB; Kolodner, KB; Lipton, RB; Schoebelock, M; Wilks, K, 2004)
"In the Second European Stroke Prevention Study headaches associated with dipyridamole frequently (8% of patients taking dipyridamole or dipyridamole plus acetylsalicylic acid (ASA) vs 2% of patients taking ASA or placebo) led to discontinuation of therapy."5.09Rapid development of tolerance to dipyridamole-associated headaches. ( Deichsel, G; Marshall, S; Theis, JG, 1999)
"Our objective was to investigate the association between recurrent stroke risk and headache induced by extended-release dipyridamole (ER-DP) when administered alone or with low-dose aspirin (ASA+ER-DP)."3.80Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis. ( Bath, PM; Cotton, D; Davidai, G; Diener, HC; Gorelick, P; Lipton, RB; Sacco, R, 2014)
"A considerable proportion of patients discontinue dipyridamole therapy because of headache."3.75Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin. ( Algra, A; Halkes, PH; Kappelle, LJ; Koudstaal, PJ; van Gijn, J, 2009)
"In the Prevention Regimen for Effectively Avoiding Second Strokes (PROFESS) trial, the combination of acetylsalicylic acid (50 mg) and extended-release dipyridamole (400 mg) (ASA+Dip) was compared with clopidogrel (75 mg) in patients with a recent transient ischaemic attack (TIA) or minor disabling stroke."3.74[Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial]. ( Kappelle, LJ, 2008)
"An adverse reaction scale characterizing common noncardiac side effects of dipyridamole in nuclear medicine cardiac patients demonstrated the most prevalent adverse reaction was headache."3.71Adverse reactions to dipyridamole in patients undergoing stress/rest cardiac perfusion testing. ( Ballow, J; Meyers, AM; Topham, L; Totah, D; Wilke, R, 2002)
"In man, intravenous infusion of adenosine has been useful in inducing sustained hypotension during anesthesia."3.67Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole. ( Biaggioni, I; Hollister, AS; Onrot, J; Robertson, D, 1986)
"Dipyridamole was associated with a slight increase in headache, which resolved in most patients if therapy was continued."2.69Secondary stroke prevention with low-dose aspirin, sustained release dipyridamole alone and in combination. ESPS Investigators. European Stroke Prevention Study. ( Forbes, CD, 1998)
"Bleeding is potentially the most significant antiplatelet-associated side effect."2.47Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events. ( Guthrie, R, 2011)
" Use of parenteral aminophylline to treat adverse events associated with intravenous dipyridamole brought complete relief of symptoms in 439 of 454 patients (96."1.28The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group. ( Kempthorne-Rawson, J; Ranhosky, A, 1990)
"Dyspnea was noted in 80 cases (40."1.27[How dangerous is the dipyridamole test?]. ( Bramann, HU; Görtz, P; Grosse-Heitmeyer, W; Mönninghoff, W; Most, E; St Müller, U, 1983)

Research

Studies (27)

TimeframeStudies, this research(%)All Research%
pre-19908 (29.63)18.7374
1990's6 (22.22)18.2507
2000's9 (33.33)29.6817
2010's3 (11.11)24.3611
2020's1 (3.70)2.80

Authors

AuthorsStudies
Kang, MK1
Cha, JK1
Chang, DI1
Kim, HY1
Chung, JW1
Jung, KH1
Hong, KS1
Chang, JY1
Rha, JH1
Park, JM1
Kim, BK1
Lee, SJ1
Park, MS1
Lee, KY1
Shin, DI1
Yoon, BW1
de Vos-Koppelaar, NC1
Kerkhoff, H1
de Vogel, EM1
Zock, E1
Dieleman, HG1
Davidai, G2
Cotton, D1
Gorelick, P1
Bath, PM1
Lipton, RB2
Sacco, R1
Diener, HC1
Kappelle, LJ2
Halkes, PH1
van Gijn, J1
Koudstaal, PJ1
Algra, A1
Lökk, J1
Guthrie, R1
Lindgren, A1
Husted, S1
Staaf, G1
Ziegler, B1
Bigal, ME1
Kolodner, KB1
Gorelick, PB1
Wilks, K1
Schoebelock, M1
Chang, YJ1
Ryu, SJ1
Lee, TH1
Schrama, E1
Eusman, JP1
Grosse-Heitmeyer, W1
Bramann, HU1
Görtz, P1
Mönninghoff, W1
St Müller, U1
Most, E1
Diamond, S1
Medina, JL1
Köhne, CH1
Hiddemann, W1
Schüller, J1
Weiss, J1
Lohrmann, HP1
Schmitz-Hübner, U1
Bodenstein, H1
Schöber, C1
Wilke, H1
Grem, J1
Olatidoye, AG1
Baltazar, RF1
Forbes, CD2
Theis, JG1
Deichsel, G1
Marshall, S1
Kruuse, C1
Jacobsen, TB1
Lassen, LH1
Thomsen, LL1
Hasselbalch, SG1
Dige-Petersen, H1
Olesen, J1
Meyers, AM1
Topham, L1
Ballow, J1
Totah, D1
Wilke, R1
Hawkes, CH1
Ranhosky, A1
Kempthorne-Rawson, J1
Biaggioni, I1
Onrot, J1
Hollister, AS1
Robertson, D1
Markman, M1
Chan, TC1
Cleary, S1
Howell, SB1
Vogel, G1
Krusch, G1
Acheson, J1
Danta, G1
Hutchinson, EC1
Sempere Leonarte, J1

Reviews

1 review available for dipyridamole and Bilateral Headache

ArticleYear
Review and management of side effects associated with antiplatelet therapy for prevention of recurrent cerebrovascular events.
    Advances in therapy, 2011, Volume: 28, Issue:6

    Topics: Aspirin; Clopidogrel; Dipyridamole; Drug Therapy, Combination; Headache; Hemorrhage; Humans; Ischemi

2011

Trials

13 trials available for dipyridamole and Bilateral Headache

ArticleYear
Effects of Dose Titration on Dipyridamole-Induced Headache: A Randomized, Double-Blind Clinical Trial.
    Cerebrovascular diseases (Basel, Switzerland), 2022, Volume: 51, Issue:4

    Topics: Aspirin; Dipyridamole; Double-Blind Method; Drug Therapy, Combination; Headache; Humans; Ischemic At

2022
The effect of a slower than standard dose escalation scheme for dipyridamole on headaches in secondary prevention therapy of strokes: a randomized, open-label trial (DOSE).
    Cerebrovascular diseases (Basel, Switzerland), 2014, Volume: 37, Issue:4

    Topics: Aspirin; Dipyridamole; Drug Therapy, Combination; Female; Headache; Humans; Ischemic Attack, Transie

2014
Dipyridamole-associated headache in stroke patients--interindividual differences?
    European neurology, 2009, Volume: 62, Issue:2

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Aspirin; Dipyridamole; Drug Therapy, Combination; Femal

2009
Dipyridamole and headache--a pilot study of initial dose titration.
    Journal of the neurological sciences, 2004, Aug-30, Volume: 223, Issue:2

    Topics: Aged; Aspirin; Dipyridamole; Drug Therapy, Combination; Female; Follow-Up Studies; Headache; Humans;

2004
Acetaminophen in the treatment of headaches associated with dipyridamole-aspirin combination.
    Neurology, 2004, Sep-28, Volume: 63, Issue:6

    Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Aspirin; Dipyridamole; Drug Combinations; Female; Hea

2004
Dose titration to reduce dipyridamole-related headache.
    Cerebrovascular diseases (Basel, Switzerland), 2006, Volume: 22, Issue:4

    Topics: Aged; Aspirin; Dipyridamole; Drug Administration Schedule; Drug Therapy, Combination; Female; Headac

2006
Failure of orally administered dipyridamole to enhance the antineoplastic activity of fluorouracil in combination with leucovorin in patients with advanced colorectal cancer: a prospective randomized trial.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:5

    Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neopla

1995
European stroke prevention study 2: dipyridamole and acetylsalicylic acid in the secondary prevention of stroke.
    International journal of clinical practice, 1997, Volume: 51, Issue:4

    Topics: Aged; Aspirin; Cerebrovascular Disorders; Dipyridamole; Disease-Free Survival; Double-Blind Method;

1997
Secondary stroke prevention with low-dose aspirin, sustained release dipyridamole alone and in combination. ESPS Investigators. European Stroke Prevention Study.
    Thrombosis research, 1998, Sep-15, Volume: 92, Issue:1 Suppl 1

    Topics: Aged; Aspirin; Cerebrovascular Disorders; Delayed-Action Preparations; Dipyridamole; Disease-Free Su

1998
Rapid development of tolerance to dipyridamole-associated headaches.
    British journal of clinical pharmacology, 1999, Volume: 48, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Studies; Dipyridamole; Double-Bl

1999
Dipyridamole dilates large cerebral arteries concomitant to headache induction in healthy subjects.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2000, Volume: 20, Issue:9

    Topics: Adolescent; Adult; Cerebral Arteries; Dipyridamole; Female; Headache; Humans; Infusions, Intravenous

2000
Dipyridamole in migraine.
    Lancet (London, England), 1978, Jul-15, Volume: 2, Issue:8081

    Topics: Clinical Trials as Topic; Dipyridamole; Headache; Humans; Migraine Disorders

1978
Controlled trial of dipyridamole in cerebral vascular disease.
    British medical journal, 1969, Mar-08, Volume: 1, Issue:5644

    Topics: Cerebrovascular Disorders; Clinical Trials as Topic; Dipyridamole; Female; Headache; Humans; Ischemi

1969

Other Studies

13 other studies available for dipyridamole and Bilateral Headache

ArticleYear
Dipyridamole-induced headache and lower recurrence risk in secondary prevention of ischaemic stroke: a post hoc analysis.
    European journal of neurology, 2014, Volume: 21, Issue:10

    Topics: Aged; Aspirin; Brain Ischemia; Delayed-Action Preparations; Dipyridamole; Drug Therapy, Combination;

2014
[Inhibition of platelet aggregation and angiotensin II-receptor blockade following TIA; the unexpected results of the Prevention Regimen For Effectively Avoiding Second Strokes (PROFESS) trial].
    Nederlands tijdschrift voor geneeskunde, 2008, Aug-30, Volume: 152, Issue:35

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Aspirin; Benzimida

2008
Risk indicators for development of headache during dipyridamole treatment after cerebral ischaemia of arterial origin.
    Journal of neurology, neurosurgery, and psychiatry, 2009, Volume: 80, Issue:4

    Topics: Aged; Aspirin; Brain Ischemia; Cerebral Arteries; Dipyridamole; Drug Therapy, Combination; Female; H

2009
[The combination of acetylsalicylic acid and dipyridamole is more effective in secondary prevention following transient ischaemic attack or cerebral infarction: the debate is closed].
    Nederlands tijdschrift voor geneeskunde, 2006, Dec-02, Volume: 150, Issue:48

    Topics: Aspirin; Cerebral Infarction; Dipyridamole; Headache; Humans; Ischemic Attack, Transient; Platelet A

2006
[How dangerous is the dipyridamole test?].
    Zeitschrift fur Kardiologie, 1983, Volume: 72, Issue:6

    Topics: Adult; Aged; Aminophylline; Angina Pectoris; Arrhythmias, Cardiac; Blood Pressure; Cardiac Complexes

1983
Newer drug therapies for headache.
    Postgraduate medicine, 1980, Volume: 68, Issue:1

    Topics: Antidepressive Agents; Aspirin; Bromocriptine; Clonidine; Cluster Headache; Dipyridamole; Headache;

1980
Dipyridamole-thallium stress testing: a local community hospital experience.
    Maryland medical journal (Baltimore, Md. : 1985), 1993, Volume: 42, Issue:7

    Topics: Aged; Aged, 80 and over; Clinical Protocols; Coronary Disease; Dipyridamole; Dyspnea; Electrocardiog

1993
Adverse reactions to dipyridamole in patients undergoing stress/rest cardiac perfusion testing.
    Journal of nuclear medicine technology, 2002, Volume: 30, Issue:1

    Topics: Chest Pain; Coronary Disease; Dipyridamole; Exercise Test; Female; Headache; Heart; Humans; Male; Na

2002
The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group.
    Circulation, 1990, Volume: 81, Issue:4

    Topics: Adult; Aged; Aminophylline; Bronchial Spasm; Chest Pain; Dipyridamole; Female; Headache; Heart; Hemo

1990
Cardiovascular effects of adenosine infusion in man and their modulation by dipyridamole.
    Life sciences, 1986, Dec-08, Volume: 39, Issue:23

    Topics: Adenosine; Anti-Arrhythmia Agents; Blood Pressure; Cardiovascular System; Dipyridamole; Dose-Respons

1986
Phase I trial of combination therapy of cancer with N-phosphonacetyl-L-aspartic acid and dipyridamole.
    Cancer chemotherapy and pharmacology, 1987, Volume: 19, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Dipyr

1987
[The effect of various drugs in clinical use on thrombocyte functions].
    Folia haematologica (Leipzig, Germany : 1928), 1969, Volume: 92, Issue:4

    Topics: Adolescent; Adult; Aged; Aminobenzoates; Aminocaproates; Arthritis, Rheumatoid; Aspirin; Blood Coagu

1969
[Contribution to the study of the treatment of headache. Prevention of attacks with dipyridamole].
    Medicina espanola, 1965, Volume: 53, Issue:316

    Topics: Adolescent; Adult; Child; Dipyridamole; Female; Headache; Humans; Male

1965