dipyridamole and Berger Disease studies

Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.

Research Excerpts

Excerpt	Relevance	Reference
"The effect of dipyridamole on proteinuria was studied in 60 children with various renal diseases."	7.67	Effect of dipyridamole treatment on proteinuria in pediatric renal disease. ( Ito, S; Kawaguchi, S; Niinomi, Y; Nonoda, T; Ohnishi, M; Ueda, N; Yasaki, T, 1986)
"Fifty-two pairs of patients with idiopathic diffuse mesangial proliferative glomerulonephritis entered a controlled 3-year prospective trial of a combination regimen of cyclophosphamide, dipyridamole and warfarin."	5.06	Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. ( Chiang, GS; Edmondson, RP; Lee, EJ; Lim, CH; Pwee, HS; Woo, KT; Wu, AY; Yap, HK, 1987)
"Children with IgA nephropathy showing diffuse (>80%) mesangial proliferation are at high risk for end-stage renal failure (ESRF)."	3.85	Long-term results of a randomized controlled trial in childhood IgA nephropathy. ( Hataya, H; Honda, M; Iijima, K; Ishikura, K; Ito, S; Kamei, K; Nakanishi, K; Saito, M; Sako, M; Yoshikawa, N, 2011)
"The effect of dipyridamole on proteinuria was studied in 60 children with various renal diseases."	3.67	Effect of dipyridamole treatment on proteinuria in pediatric renal disease. ( Ito, S; Kawaguchi, S; Niinomi, Y; Nonoda, T; Ohnishi, M; Ueda, N; Yasaki, T, 1986)
" Ligustrazine with the dosage of 80 mg twice a day was given to 25 patients in the treatment group by intravenous perfusion besides the medicine used in the control group."	2.71	[Effect of ligustrazine on proliferative glomerulonephritis]. ( Tang, X, 2003)
"Group A comprised 12 patients with IgA nephropathy, who had 24-h proteinuria of 0."	2.71	Comparison of antiproteinuric effects of two different combination therapies in children with IgA nephropathy. ( Ikeda, M; Kuwajima, H; Okada, M; Sugimoto, K; Takemura, T; Yagi, K; Yanagida, H, 2003)
"Treatment with prednisolone, azathioprine, heparin-warfarin, and dipyridamole early in the course of disease may prevent immunologic renal injury in children with severe IgA nephropathy."	2.69	A controlled trial of combined therapy for newly diagnosed severe childhood IgA nephropathy. The Japanese Pediatric IgA Nephropathy Treatment Study Group. ( Awazu, M; Hattori, S; Honda, M; Iitaka, K; Ito, H; Ito, K; Koitabashi, Y; Matsuyama, S; Nakagawa, K; Nakamura, H; Ninomiya, M; Sakai, T; Seino, Y; Takeda, N; Takekoshi, Y; Yamaoka, K; Yoshikawa, N, 1999)
"The early stage of progressive IgA nephropathy was defined as having moderate proteinuria between 1 and 2 g/day, creatinine clearance values of 70 ml/min or more, and a histological severity score of 7 or more."	2.68	Steroid therapy during the early stage of progressive IgA nephropathy. A 10-year follow-up study. ( Hiki, Y; Horii, A; Kobayashi, Y; Kokubo, T; Tateno, S, 1996)
"Of 52 patients with mesangial IgA nephropathy, 25 were allocated to treatment with cyclophosphamide (6 months), and dipyridamole and warfarin (2 years) and 27 to no treatment in a randomized prospective 2-year study."	2.67	The treatment of mesangial IgA nephropathy with cyclophosphamide, dipyridamole and warfarin: a two-year prospective trial. ( Kincaid-Smith, P; Owen, JE; Walker, RG; Yu, SH, 1990)
"With treatment of prednisolone, an angiotensin-converting enzyme inhibitor, and an angiotensin II receptor-blocker, his proteinuria markedly decreased and renal function was stabilized."	2.43	Nephrotic syndrome and IgA nephropathy in polycystic kidney disease. ( Gejyo, F; Hiura, T; Kawabe, S; Miyamura, S; Nishi, S; Saeki, T; Ueno, M; Yamazaki, H, 2006)
"The prognosis of children with severe IgA nephropathy showing diffuse mesangial proliferation is poor."	1.37	Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy. ( Iijima, K; Kamei, K; Nakanishi, K; Nozu, K; Sasaki, S; Shima, Y; Tanaka, R; Togawa, H; Yoshikawa, N, 2011)
"Three years after the initiation of treatment, proteinuria and hematuria had significantly decreased in both groups, and the renal function in Group B was significantly improved."	1.29	Early intensive therapy for clinical remission of active IgA nephropathy: a three-year follow-up study. ( Horigome, I; Hotta, O; Kurosawa, K; Sudo, K; Suzuki, K; Taguma, Y, 1993)
"45 cases of IgA nephropathy were confirmed by renal biopsy and were divided into 2 groups, the integrated traditional and western medicine (TCM-WM) therapeutic group and the western medicine (WM) therapeutic group."	1.28	[Treatment of IgA nephropathy by integrated traditional and Western medicine]. ( Ye, RG, 1992)
"Thirty-three cases of idiopathic IgA nephropathy were followed up for an average of 90."	1.28	IgA nephropathy: a long-term progressive study. ( Górski, A; Lao, M; Małdyk, M; Morzycka-Michalik, M; Orłowski, T; Rancewicz, Z; Smogorzewski, M; Szczesny-Nowicka, B, 1990)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (26.83)	18.7374
1990's	11 (26.83)	18.2507
2000's	14 (34.15)	29.6817
2010's	4 (9.76)	24.3611
2020's	1 (2.44)	2.80

Trial			Phase	Enrollment	Study Type	Start Date	Status
Phase IV Open Label Uncontrolled Trial of the Dual Blockade of the Renin Angiotensin System With Enalapril Plus Valsartan Combined With Oral Methylprednisolone for the Treatment of Proteinuria in IGA Nephropathy[NCT00367562]			Phase 4	20 participants	Interventional	1996-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
[Treatment of childhood IgA nephropathy]. Nihon Jinzo Gakkai shi, 2008, Volume: 50, Issue:4 Topics: Azathioprine; Child; Dipyridamole; Drug Therapy, Combination; Evidence-Based Medicine; Glomeruloneph	2008
Long-term results of a randomized controlled trial in childhood IgA nephropathy. Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:6 Topics: Adolescent; Anticoagulants; Azathioprine; Cell Proliferation; Child; Dipyridamole; Disease Progressi	2011
Nephrotic syndrome and IgA nephropathy in polycystic kidney disease. Clinical and experimental nephrology, 2006, Volume: 10, Issue:2 Topics: Aged; Biopsy; Dipyridamole; Glomerulonephritis, IGA; Humans; Kidney; Losartan; Male; Nephrotic Syndr	2006
IgA glomerulonephritis: beyond angiotensin-converting enzyme inhibitors. Nature clinical practice. Nephrology, 2006, Volume: 2, Issue:1 Topics: Angiotensin-Converting Enzyme Inhibitors; Dipyridamole; Disease Progression; Drug Therapy, Combinati	2006
Meta-analysis of antiplatelet therapy for IgA nephropathy. Clinical and experimental nephrology, 2006, Volume: 10, Issue:4 Topics: Dilazep; Dipyridamole; Glomerulonephritis, IGA; Humans; Kidney Function Tests; Platelet Aggregation	2006

Article	Year
Combination therapy with or without warfarin and dipyridamole for severe childhood IgA nephropathy: an RCT. Pediatric nephrology (Berlin, Germany), 2018, Volume: 33, Issue:11 Topics: Adolescent; Biopsy; Child; Dipyridamole; Drug Therapy, Combination; Female; Glomerular Mesangium; Gl	2018
Long-term results of a randomized controlled trial in childhood IgA nephropathy. Clinical journal of the American Society of Nephrology : CJASN, 2011, Volume: 6, Issue:6 Topics: Adolescent; Anticoagulants; Azathioprine; Cell Proliferation; Child; Dipyridamole; Disease Progressi	2011
Effect of fluvastatin and dipyridamole on proteinuria and renal function in childhood IgA nephropathy with mild histological findings and moderate proteinuria. Clinical nephrology, 2003, Volume: 60, Issue:2 Topics: Adolescent; Child; Dipyridamole; Drug Therapy, Combination; Fatty Acids, Monounsaturated; Female; Fl	2003
[Effect of ligustrazine on proliferative glomerulonephritis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials, 2003, Volume: 26, Issue:8 Topics: Adolescent; Adult; Creatinine; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Female; Fi	2003
Comparison of antiproteinuric effects of two different combination therapies in children with IgA nephropathy. Clinical and experimental nephrology, 2003, Volume: 7, Issue:4 Topics: Adolescent; Adult; Age of Onset; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents;	2003
[Effects of Astragalus injection on renal tubular function in patients with IgA nephropathy]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2006, Volume: 26, Issue:6 Topics: Adolescent; Adult; Astragalus propinquus; Benzazepines; Dipyridamole; Drug Therapy, Combination; Dru	2006
Steroid treatment for severe childhood IgA nephropathy: a randomized, controlled trial. Clinical journal of the American Society of Nephrology : CJASN, 2006, Volume: 1, Issue:3 Topics: Azathioprine; Child; Dipyridamole; Female; Glomerulonephritis, IGA; Glucocorticoids; Humans; Male; P	2006
Combination therapy with mizoribine for severe childhood IgA nephropathy: a pilot study. Pediatric nephrology (Berlin, Germany), 2008, Volume: 23, Issue:5 Topics: Biopsy; Child; Dipyridamole; Disease Progression; Female; Follow-Up Studies; Glomerulonephritis, IGA	2008
Steroid therapy during the early stage of progressive IgA nephropathy. A 10-year follow-up study. Nephron, 1996, Volume: 72, Issue:2 Topics: Adult; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Dipyridamole; Disease Prog	1996
A controlled trial of combined therapy for newly diagnosed severe childhood IgA nephropathy. The Japanese Pediatric IgA Nephropathy Treatment Study Group. Journal of the American Society of Nephrology : JASN, 1999, Volume: 10, Issue:1 Topics: Adolescent; Azathioprine; Blood Urea Nitrogen; Child; Dipyridamole; Drug Therapy, Combination; Glome	1999
Combined therapy with prednisolone, azathioprine, heparin-warfarin, and dipyridamole for paediatric patients with severe IgA nephropathy--is it relevant for adult patients? Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:5 Topics: Adult; Anticoagulants; Azathioprine; Child; Dipyridamole; Drug Therapy, Combination; Glomerulonephri	1999
Effects of triple therapy in IgA nephritis: a follow-up study 5 years later. Clinical nephrology, 1991, Volume: 36, Issue:2 Topics: Adult; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Female; Follow-Up Studies; Glomeru	1991
The treatment of mesangial IgA nephropathy with cyclophosphamide, dipyridamole and warfarin: a two-year prospective trial. Clinical nephrology, 1990, Volume: 34, Issue:3 Topics: Adult; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Female; Glomerulonephritis, IGA; H	1990
Controlled trial of dipyridamole and low-dose warfarin in patients with IgA nephritis with renal impairment. Clinical nephrology, 1989, Volume: 31, Issue:5 Topics: Adult; Clinical Trials as Topic; Dipyridamole; Female; Glomerulonephritis, IGA; Humans; Male; Nephri	1989
Clinical effect of danazol in patients with IgA nephropathy. Japanese journal of medicine, 1987, Volume: 26, Issue:2 Topics: Administration, Oral; Adult; Clinical Trials as Topic; Complement C3; Complement C4; Danazol; Dipyri	1987
Effects of triple therapy on the progression of mesangial proliferative glomerulonephritis. Clinical nephrology, 1987, Volume: 27, Issue:2 Topics: Adult; Clinical Trials as Topic; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Female;	1987
Controlled trial of antiplatelet agents in mesangial IgA glomerulonephritis. American journal of kidney diseases : the official journal of the National Kidney Foundation, 1987, Volume: 9, Issue:5 Topics: Adult; Aspirin; Blood Platelets; Clinical Trials as Topic; Creatinine; Delayed-Action Preparations;	1987

Article	Year
Myocardial ischemia during methylprednisolone pulse therapy with dipyridamole. Pediatrics international : official journal of the Japan Pediatric Society, 2021, Volume: 63, Issue:6 Topics: Dipyridamole; Glomerulonephritis, IGA; Humans; Methylprednisolone; Myocardial Ischemia; Pulse Therap	2021
Disappearance of glomerular IgA deposits in childhood IgA nephropathy showing diffuse mesangial proliferation after 2 years of combination/prednisolone therapy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:1 Topics: Anti-Inflammatory Agents; Anticoagulants; Azathioprine; Child; Dipyridamole; Drug Therapy, Combinati	2011
Benefit of cyclophosphamide therapy in IgA nephritis may have been obscured by warfarin-related nephropathy in the randomized trials in which warfarin and dipyridamole were used in combination with cyclophosphamide. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2012, Volume: 27, Issue:2 Topics: Acute Kidney Injury; Adult; Child; Cohort Studies; Cyclophosphamide; Dipyridamole; Drug Therapy, Com	2012
Does growth hormone therapy induce IgA nephropathy? Pediatric nephrology (Berlin, Germany), 2005, Volume: 20, Issue:12 Topics: Child, Preschool; Dipyridamole; Follow-Up Studies; Glomerulonephritis, IGA; Growth Hormone; Humans;	2005
IgA nephropathy associated with leukemia and lymphoma: report of two cases. Clinical and experimental nephrology, 2008, Volume: 12, Issue:2 Topics: Adrenal Cortex Hormones; Antineoplastic Combined Chemotherapy Protocols; Child; Child, Preschool; Di	2008
Combined therapy in children and adolescents with IgA nephropathy. Nihon Jinzo Gakkai shi, 1994, Volume: 36, Issue:1 Topics: Adolescent; Child; Child, Preschool; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Fema	1994
Early intensive therapy for clinical remission of active IgA nephropathy: a three-year follow-up study. Nihon Jinzo Gakkai shi, 1993, Volume: 35, Issue:8 Topics: Adolescent; Adult; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Female; Follow-Up Stud	1993
Dipyridamole and low-dose warfarin without cyclophosphamide in the management of IgA nephropathy. Kidney international, 2000, Volume: 57, Issue:1 Topics: Anticoagulants; Cyclophosphamide; Dipyridamole; Dose-Response Relationship, Drug; Glomerulonephritis	2000
Mumps associated with immunoglobulin A nephropathy. The Pediatric infectious disease journal, 2000, Volume: 19, Issue:7 Topics: Antibodies, Viral; Biopsy; Child, Preschool; Dipyridamole; Enzyme-Linked Immunosorbent Assay; Glomer	2000
[Treatment of IgA nephropathy by integrated traditional and Western medicine]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 1992, Volume: 12, Issue:1 Topics: Adolescent; Adult; Child; Child, Preschool; Dipyridamole; Drugs, Chinese Herbal; Female; Glomerulone	1992
A case of IgA nephritis showing diffuse podocytic detachment from the glomerular basement membrane. Nihon Jinzo Gakkai shi, 1992, Volume: 34, Issue:4 Topics: Adolescent; Basement Membrane; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Female; Fu	1992
The treatment of mesangial IgA nephropathy with cyclophosphamide, dipyridamole and warfarin. Clinical nephrology, 1991, Volume: 35, Issue:4 Topics: Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Glomerulonephritis, IGA; Humans; Warfarin	1991
IgA nephropathy: a long-term progressive study. Mineral and electrolyte metabolism, 1990, Volume: 16, Issue:1 Topics: Adolescent; Adult; Aspirin; Child; Creatinine; Dipyridamole; Female; Glomerulonephritis, IGA; Humans	1990
Moderately proteinuric IgA nephropathy: prognostic prediction of individual clinical courses and steroid therapy in progressive cases. Nephron, 1989, Volume: 53, Issue:3 Topics: Adrenal Cortex Hormones; Adult; Anti-Inflammatory Agents, Non-Steroidal; Blood Pressure; Dipyridamol	1989
Clinical effect of dipyridamole in patients with IgA nephropathy. The Tokai journal of experimental and clinical medicine, 1986, Volume: 11, Issue:5 Topics: Adrenochrome; Dipyridamole; Glomerulonephritis; Glomerulonephritis, IGA; Hematuria; Humans; Proteinu	1986
Rapidly progressive IgA nephropathy. American journal of diseases of children (1960), 1988, Volume: 142, Issue:7 Topics: Adolescent; Child; Complement C3; Complement C4; Dipyridamole; Female; Glomerulonephritis, IGA; Huma	1988
Controlled therapeutic trial of IgA nephritis with follow-up renal biopsies. Annals of the Academy of Medicine, Singapore, 1988, Volume: 17, Issue:2 Topics: Biopsy, Needle; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Glomerulonephritis, IGA;	1988
Follow-up renal biopsies in IgA nephritic patients on triple therapy. Clinical nephrology, 1987, Volume: 28, Issue:6 Topics: Biopsy, Needle; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Follow-Up Studies; Glomer	1987
IgA nephritis in Singapore: clinical, prognostic indices, and treatment. Seminars in nephrology, 1987, Volume: 7, Issue:4 Topics: Adult; Age Factors; Cyclophosphamide; Dipyridamole; Drug Therapy, Combination; Female; Follow-Up Stu	1987
Effect of dipyridamole treatment on proteinuria in pediatric renal disease. Nephron, 1986, Volume: 44, Issue:3 Topics: Adolescent; Child; Child, Preschool; Chronic Disease; Dipyridamole; Female; Glomerulonephritis; Glom	1986

dipyridamole and Berger Disease

Research Excerpts

Research

Studies (41)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Authors	Studies
Tsukahara, T	1
Matsuoka, D	1
Shimada, S	1
Hachiya, A	1
Motoki, N	1
Shima, Y	2
Nakanishi, K	5
Kaku, Y	1
Ishikura, K	3
Hataya, H	3
Matsuyama, T	1
Honda, M	5
Sako, M	2
Nozu, K	2
Tanaka, R	2
Iijima, K	5
Yoshikawa, N	8
Kamei, K	2
Togawa, H	1
Sasaki, S	1
Ito, S	2
Saito, M	1
Brodsky, SV	1
Rovin, BH	1
Hebert, LA	1
Kano, K	2
Nishikura, K	2
Yamada, Y	1
Arisaka, O	2
Tang, X	1
Yagi, K	2
Okada, M	2
Yanagida, H	1
Kuwajima, H	1
Ikeda, M	1
Sugimoto, K	1
Takemura, T	2
Hiura, T	1
Yamazaki, H	1
Saeki, T	1
Kawabe, S	1
Ueno, M	1
Nishi, S	1
Miyamura, S	1
Gejyo, F	1
Li, SM	1
Yan, JX	1
Yang, L	1
Locatelli, F	1
Vecchio, LD	1
Pozzi, C	1
Taji, Y	1
Kuwahara, T	1
Shikata, S	1
Morimoto, T	1
Awazu, M	2
Hattori, S	2
Ito, H	3
Motoyama, O	1
Kojima, Y	1
Ohara, A	1
Tsukimoto, I	1
Ishikawa, Y	1
Iitaka, K	2
Murakami, K	1
Yoshioka, K	1
Akano, N	1
Aya, N	1
Hino, S	1
Miyazato, H	1
Maki, S	1
Hotta, O	1
Taguma, Y	1
Kurosawa, K	1
Sudo, K	1
Suzuki, K	1
Horigome, I	1
Kobayashi, Y	2
Hiki, Y	2
Kokubo, T	1
Horii, A	1
Tateno, S	2
Sakai, T	1
Takekoshi, Y	1
Ito, K	1
Koitabashi, Y	1
Yamaoka, K	1
Nakagawa, K	1
Nakamura, H	1
Matsuyama, S	1
Seino, Y	1
Takeda, N	1
Ninomiya, M	1
Woo, KT	8
Lee, GS	4
Pall, AA	1
Fujieda, M	1
Kinoshita, A	1
Naruse, K	1
Nakayama, T	1
Moriki, T	1
Wakiguchi, H	1
Kurashige, T	1
Ye, RG	1
Moriya, T	1
Nakazawa, K	1
Itoh, N	1
Shigematsu, H	1
Higuchi, M	1
Miyasaka, M	1
Oguchi, H	1
Lau, YK	2
Chiang, GS	5
Lim, CH	6
Walker, RG	1
Yu, SH	1
Owen, JE	1
Kincaid-Smith, P	1
Orłowski, T	1
Górski, A	1
Rancewicz, Z	1
Morzycka-Michalik, M	1
Smogorzewski, M	1
Małdyk, M	1
Lao, M	1
Szczesny-Nowicka, B	1
Fujii, K	1
Kurokawa, A	1
Yagame, M	1
Tomino, Y	2
Miura, M	1
Suga, T	1
Endoh, M	1
Nomoto, Y	1
Sakai, H	2
Welch, TR	1
McAdams, AJ	1
Berry, A	1
Hanzawa, S	1
Ohno, J	1
Kitajima, T	1
Sakai, O	1
Yap, HK	2
Edmondson, RP	1
Wu, AY	1
Lee, EJ	1
Pwee, HS	1
Chan, MK	1
Kwan, SY	1
Chan, KW	1
Yeung, CK	1
Ueda, N	1
Kawaguchi, S	1
Niinomi, Y	1
Nonoda, T	1
Ohnishi, M	1
Yasaki, T	1