dipyridamole has been researched along with Achlorhydria in 6 studies
Dipyridamole: A phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells. Dipyridamole also potentiates the antiaggregating action of prostacyclin. (From AMA Drug Evaluations Annual, 1994, p752)
dipyridamole : A pyrimidopyrimidine that is 2,2',2'',2'''-(pyrimido[5,4-d]pyrimidine-2,6-diyldinitrilo)tetraethanol substituted by piperidin-1-yl groups at positions 4 and 8 respectively. A vasodilator agent, it inhibits the formation of blood clots.
Achlorhydria: A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dipyridamole (DP) is an antiplatelet agent that shows decreased oral bioavailability with increased gastric pH that occurs with commonly prescribed antacids." | 2.71 | Dipyridamole bioavailability in subjects with reduced gastric acidity. ( Brickl, RS; Derendorf, H; Eisert, W; MacGregor, TR; VanderMaelen, CP, 2005) |
| "The bioavailability of dipyridamole, a poorly soluble weak base, was evaluated in 11 healthy, older subjects (> or = 65 years), 6 with a low fasting gastric pH (control) and 5 with a fasting gastric pH > 5 (achlorhydric), in a randomized, crossover design." | 2.67 | pH-related changes in the absorption of dipyridamole in the elderly. ( Barnett, JL; Berardi, RR; Dressman, JB; O'Sullivan, TL; Russell, TL; Wagner, JG, 1994) |
| "The aim of this study was to develop new dipyridamole (DP) salts with pH-independent solubility for improving oral bioavailability under hypochlorhydria." | 1.39 | New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions. ( Inoue, R; Kato, M; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K, 2013) |
| " Pharmacokinetic profiling of orally dosed DPG or DPG with 60% loading of FA (DPG/FA60) was carried out in omeprazole-treated rats as a hypochlorhydric model." | 1.38 | Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. ( Inoue, R; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K; Yamauchi, Y, 2012) |
| "However, AUC(0-3) for DPG/TS under hypochlorhydria was almost identical to that of DPG in normal rats." | 1.38 | Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria. ( Inoue, R; Kawabata, Y; Onoue, S; Taniguchi, C; Wada, K; Yamada, S; Yamashita, K; Yamauchi, Y, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Taniguchi, C | 3 |
| Inoue, R | 3 |
| Kato, M | 1 |
| Yamashita, K | 3 |
| Kawabata, Y | 3 |
| Wada, K | 3 |
| Yamada, S | 3 |
| Onoue, S | 3 |
| Yamauchi, Y | 2 |
| Derendorf, H | 1 |
| VanderMaelen, CP | 1 |
| Brickl, RS | 1 |
| MacGregor, TR | 1 |
| Eisert, W | 1 |
| Sugawara, M | 1 |
| Kadomura, S | 1 |
| He, X | 1 |
| Takekuma, Y | 1 |
| Kohri, N | 1 |
| Miyazaki, K | 1 |
| Russell, TL | 1 |
| Berardi, RR | 1 |
| Barnett, JL | 1 |
| O'Sullivan, TL | 1 |
| Wagner, JG | 1 |
| Dressman, JB | 1 |
2 trials available for dipyridamole and Achlorhydria
| Article | Year |
|---|---|
Dipyridamole bioavailability in subjects with reduced gastric acidity.
Topics: Achlorhydria; Adult; Aspirin; Biological Availability; Cross-Over Studies; Dipyridamole; Drug Combin | 2005 |
pH-related changes in the absorption of dipyridamole in the elderly.
Topics: Achlorhydria; Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Dipyridamole; Famotidin | 1994 |
4 other studies available for dipyridamole and Achlorhydria
| Article | Year |
|---|---|
New dipyridamole salt with improved dissolution and oral bioavailability under hypochlorhydric conditions.
Topics: Achlorhydria; Administration, Oral; Animals; Biological Availability; Dipyridamole; Humans; Hydrogen | 2013 |
Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria.
Topics: Achlorhydria; Administration, Oral; Animals; Area Under Curve; Biological Availability; Chemistry, P | 2012 |
Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria.
Topics: Achlorhydria; Administration, Oral; Animals; Area Under Curve; Benzenesulfonates; Biological Availab | 2012 |
The use of an in vitro dissolution and absorption system to evaluate oral absorption of two weak bases in pH-independent controlled-release formulations.
Topics: Achlorhydria; Administration, Oral; Albendazole; Caco-2 Cells; Cell Membrane Permeability; Chemistry | 2005 |